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Biomedical subjects

G Hulman

Publications and source records attributed to G Hulman.

15 recordsLinked to original sources
PubMed1995

The pathogenesis of fat embolism.

Fat embolism is a common autopsy finding in patients with or without a history of trauma. There are two basic mechanisms causing fat to embolize. Depot-derived fat embolism arises by disruption of depot fat, usually as a result of trauma, allowing direct entry into the bloodstream. Plasma-derived fat embolism is caused by agglutination of endogenous or infused exogenous fat such as Intralipid, with consequent embolism. Chylomicrons and Intralipid liposomes are known to undergo calcium-dependent agglutination by C-reactive protein (CRP), and this may play a role in vivo in this type of fat embolism.

Bone Marrow↗
PubMed1992

Oral contraceptive use and histopathology of cancerous breasts in young women. Members of the U.K. National Case-Control Study Group.

A retrospective histopathological study of 300 women under 36 years of age was carried out to determine whether breast cancers occurring in oral contraceptive users showed any differences in pathological features compared with non-users. The patients belong to an age group in which an increased risk of cancer development has been reported following oral contraceptive usage. The incidence of non-neoplastic conditions in the residual breast was also studied in the two groups. There was little difference between breast cancers arising in pill users and non-users but in the residual non-neoplastic breast a decreased incidence of cysts and blunt duct adenosis was found in current users of the contraceptive pill. In contrast, lactational foci were found only in the breasts of pill users. The incidence of intraductal hyperplasia was not significantly different in the two groups.

Adult↗
PubMed1988

Pathogenesis of non-traumatic fat embolism.

Like the liposomes of certain intravenous fat emulsions associated with embolic effects in acutely ill patients, chylomicrons and very low density lipoproteins (VLDL) show calcium-dependent agglutination by C-reactive protein (CRP). It is suggested that non-traumatic fat embolism may be caused by agglutination of chylomicrons and VLDL by high levels of plasma CRP. This mechanism may also cause acute pancreatitis in patients with types I, IV, and V hyperlipidaemia, and avascular necrosis of bone in patients with corticosteroid-induced hyperlipidaemia.

Agglutination↗
PubMed1987

Comparison of fat agglutination slide test and latex test for C-reactive protein.

A slide test for detecting elevated levels of serum CRP using Intralipid and calcium chloride is described. The test obtains results similar to those of a latex agglutination test with which it was compared. The test is extremely quick and easy to perform. It may be of use as a cheap alternative to latex agglutination as a rapid screening or bedside test for elevated levels of CRP.

C-Reactive Protein↗
PubMed1986

Intralipid microemboli.

A baby girl died after receiving intravenous Intralipid. At necropsy a pulmonary Intralipid microembolus, unrelated to the cause of death, was found. Serum taken immediately before infusion agglutinated Intralipid. C reactive protein concentration was raised. This supports the theory that C reactive protein may agglutinate Intralipid in vivo, causing embolisation.

C-Reactive Protein↗
PubMed1982

Agglutination of intralipid by sera of acutely ill patients.

The serum of over half of a group of acutely ill patients agglutinated "Intralipid' a fat emulsion based on soya bean oil designed for intravenous infusion. This reaction is probably precipitated by C-reactive protein in the presence of calcium ions. Post-mortem examinations of patients who had received intralipid showed evidence of microembolism which could have been caused by agglutination of intralipid. If this is the case then intralipid should perhaps not be given to these acutely ill patients.

Acute Disease↗