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Biomedical subjects

G Hudson

Publications and source records attributed to G Hudson.

At least 73 records · Page 4Linked to original sources
PubMed1976

Ultrastructure of simian eosinophils.

The ultrastructure of eosinophil granulocytes has been studied in the bone marrow and nasal mucosa of the monkey. Both the mature eosinophils and their precursors, including the form and dimensions of their granules, were generally similar to those of man and rodents. Unusual features in the marrow were the occasional presence of an irregular substructure in granules without interna, or of cytoplasmic vacuoles containing material apparently derived from granule breakdown. In the nasal mucosa, eosinophils were present in both the epithelium and in the sub-epithelial tissues. The lattice arrangement of the eosinophil internum had a spacing of up to 5-4 nm, with sometimes a secondary repeat of 2-7 nm, and suggested a more complex crystal structure than that of man and rodents.

Animals↗
PubMed1975

Skin window studies in polycythaemia rubra vera.

The inflammatory response was studied in patients with primary polycythaemia by means of a modified skin window technique. In untreated patients, the overall cellularity was a prominent feature and, as compared with the controls, the 48 h preparations showed a significantly greater percentage of granulocytes with a corresponding decreased percentage of macrophages. In the peripheral blood of these patients, both total white cells and granulocyte counts were significantly higher than in the control subjects. A highly significant relationship between the blood and skin window neutrophils was demonstrated. In polycythaemia patients in remission, the results were generally similar to the controls, except that there was still a highly significant increase in the percentage of skin window basophils. The results provided no evidence of a defect in cell migration or in the phagocytic activity of macrophages in polycythaemia vera. Possible mechanisms of the cutaneous basophilia and its relevance to the manifestation of this disorder are discussed.

Adult↗