Search PubMed⌕ Search

Biomedical subjects

G Huchon

Publications and source records attributed to G Huchon.

At least 91 records · Page 5Linked to original sources
PubMed1981

Multiple pulmonary arterial aneurysms in Behcet's disease and Hughes-Stovin syndrome.

Four case studies of patients with angiographically documented pulmonary arterial aneurysms are presented. In two cases, Behcet's disease was diagnosed; one case corresponded to the syndrome described by Hughes and Stovin, that is, venous thrombosis especially of the vena cava accompanied by singular or multiple pulmonary arterial aneurysms in young patients; and the last case could best be described as an association of the two. Our observations lead us to question the existing notions concerning the relationship between Behcet's disease and Hughes-Stovin syndrome-the clinical, angiographic and histologic aspects of the vascular manifestations are comparable. Typically the two diseases run similar courses with death resulting frm the rupture of the aneurysms and massive hemoptysis. These case studies cast certain doubts as to the effectiveness of the corticosteroid treatment usually prescribed. Finally, we suggest that Hughes-Stovin syndrome might be, in fact, a manifestation of Behcet's disease.

Adult↗
PubMed1981

[Pleuro-pulmonary disease and rigid spine syndrome (author's transl)].

A case of rigid spine syndrome associated with a pleuropulmonary disease is reported. This case is the ninth known rigid spine syndrome but it is the first associated with a diffuse pleural and pulmonary involvement. Clinical examination showed limitation of flexion of the spine since early infancy and limitation of extension of the elbows. Fibrosis probably involved both the lung and the pleura, although microscopic examination showed limitation of flexion of the spine since early infancy and limitation of extension of the elbows. Fibrosis probably involved both the lung and the pleura, although microscopic examination are not available. Severity of respiratory failure is explained by involvement of lungs, pleura and chest wall. Future is explained by involvement of lungs, pleura and chest wall. Future studies of similar case are needed to answer the questions whether or not this association is casual and if lung and muscular involvement are linked.

Adult↗
PubMed1980

[Deposition of particles in the respiratory system].

Aerosols consist of two phases: a gas phase and particle phase, either liquid or solid. Mathematical modeling of the three principal processes (impaction, sedimentation and diffusion) which determine the amounts of deposition of particles at various levels of the respiratory system is in agreement with the majority of experimental data, the upper airways behaving as a very effective filter for particles with an aerodynamic diameter greater than 2 micron. Below such a diameter, particles are capable of being deposited at all levels along the tracheo-bronchial system or in the terminal respirator units. This scale of micronic aerodynamic diameters furthermore corresponds to atmospheric aerosols with a long duration (monodispersed aerosols). Such findings have obvious consequences both in terms of the physiopathology of respiratory disorders as well as the therapeutic or diagnostic use of aerosols. In order to better define the deposition of infra-micronic particles, we used the Liu and Whitby analyser for measurement of particle concentration for diameters of between 0.0042 micron and 0.75 micron. The aerosol inhaled was ordinary atmospheric air with a stable profile. The respiratory tract of the subject was free of any particles after 5 respiratory cycles through a filter. Overall, expired particle concentrations decreased exponentially with the increase in apnea at the end of inspiration. This decrease was all the more marked when pulmonary capacity was smaller. These findings were apparently related to the increased probability of deposition by diffusion as the dimension of the air spaces decreases.

Aerosols↗
PubMed1979

[Intrapulmonary deposition of inframicron particles during inspiratory apnea (author's transl)].

An experimental approach of the intrapulmonary deposition of particles with a diameter below 1 micron, suspended in the surrounding atmosphere, was done on two normal subjects during inspiratory apnea with a Whitby impactor. The first results seem to agree with those of literature and confirm the importance of pulmonary morphometric factors in the deposition processes. Numerous methodological problems remain, but it appears that the technique would be useful to evaluate the likelyhood of deposition of submicron particles which are presently known to be pathogenic.

Apnea↗
PubMed1977

[Extrinsic allergic alveolitis of drug origin].

Extrinsic allergic alveolitis of drug origin is now a better known branch of respiratory pathology. The symptoms and course of these cases resemble in many ways those of extrinsic allergic alveolitis in general with a few differences. The list of drugs responsible is longer every day, and it is important to be aware of it. The diagnosis of these diseases is not always easy, as there are certain similarities between them and other long diseases either iatrogenic or not, but not immuno-allergic. Our physiopathological knowledge is based on already known data concerning allergic alveolitis, but includes many theories which still have to be verified. It is important for the clinician to be aware of this new type of respiratory disease as the treatment includes withdrawal of the responsible drug as soon as possible, failing which irreversible pulmonary fibrosis develops.

Alveolitis, Extrinsic Allergic↗
PubMed1976

[Paraneoplastic hypercalcemia in primary bronchial cancer].

Paraneoplastic hypercalcemia is frequently observed in squamous cell carcinoma of the bronchus. Clinically, apart from the general symptoms which are always very marked, neurological signs are the most common. This hypercalcemia, accompanied by hypophosphatemia, is of sudden onset and immediately very high. Metabolic alkalosis, with hypokalemia and hypochloremia, differentiates it from true hyperparathyroidism. Symptomatic treatment is only transiently effective. However, the obvious effect of mitramycin may be useful before surgical operation, which alone produces a lasting normalisation of serum calcium. Inappropriate secretion of a parathormone substance by the tumour may be demonstrated by radio-immunoassay, and this explains a large number of cases of hypercalcemia but this does not exclude other possible factors in the etiology. Finally, hypercalcemia originally attributed to bony lysis, may be explained in some cases by a paraneoplastic process.

Acidosis↗
PubMed1976

Continuous intravascular monitoring of pO2 and pCO2. A comparative in vitro-in vivo study.

Two electrodes placed at the tip of catheters for in vivo determinations of PCO2 and PO2 respectively, were tested in dogs. Results were satisfactory when compared to a highly accurate reference method, correlation coefficients were close to 1 (P less than 10(-9)). Means of the differences were respectively --1.74 +/- 1.14 toor for the PO2 probe (P less than 0.01) and --1.62 +/- 0.72 torr for the PCO2 sensor (P less than 0.0001). While no drift was detected in the PCO2 electrode, that of the PO2 was significant but negligible compared to the variability of measurements. Thus, for PCO2 values between 20 and 85 torr, and PO2 values between 20 and 140 torr, in vivo monitoring is sufficiently reliable for clinical use.

Animals↗
PubMed1976

[Pickwickian syndrome and hypersomnia with periodic respiration].

A classical definition of Pickwickian syndrome associates alveolar hypoventilation, obesity and hypersomnia with periodic breathing. Obesity in itself is enough to explain the alveolar hypoventilation and some of the sleep disorders, but in fact all three elements of this syndrome are intricated. Obesity, whether associated with a Pickwickian syndrome or not, affects ventilatory mechanics similarly. With the cause of sleep disorders are associated central ventilatory pauses, appearing periodically followed by phases of apnoea secondary to buccopharyngial hypotony. The alveolar hypoventilation is therefore the consequence of obesity and periodic apnoea. It also results from a low respiratory frequency considering that the tidal volume is also decreased. These different elements suggest some disorder of the centers controling ventilation. One can describe different nosological forms, all having as a common factor hypersomnia with periodic respiration, the latter being a determining factor in the diagnosis. Therapy, including weight reduction and symptomatic treatment of alveolar hypoventilation, is now augmented by new drugs acting on the central nervous system.

Circadian Rhythm↗
PubMed1976

[Bronchiolo-alveolar cancer].

The bronchiolo-alveolar adenocarcinoma, less frequent than other types of bronchopulmonary cancers, occurs more frequently during pulmonary fibrosis. Besides a mucous bronchorrhea of little meaning, the clinical manifestations belong to the advanced stages. The X-ray, unreliable and variable, shows a variety of pictures from mono or multinodular ones to pseudopneumonic infiltrates. Usually no information could be derived from bronchoscopy. Positive cytological examination of sputum are unfrequent. Early surgery brings longer remissions than in other types of bronchopulmonary cancer. Diagnosis can only be made from the histology of the exeresis sample. The tumour cells, cuboidal or columnar, are arranged in mono or pluri-stratified layers in the inter-alveolar septa, which progressively become fibrous. This cancer has an original histogenesis: it would originate from the neoplastic metaplasia of type II pneumocytes or of respiratory bronchiole cells, invading the pulmonary alveoli by sliding or by contiguity. Far from the initial foyer, the spreading seems mostly done through airways.

Adenocarcinoma, Bronchiolo-Alveolar↗