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Biomedical subjects

G Huber

Publications and source records attributed to G Huber.

At least 235 records · Page 13Linked to original sources
PubMed1977

Relationship between the populations of Streptococcus mutans in the mouth and feces of conventional Sprague-Dawley rats.

The relationship between oral and fecal S mutans populations has been studied in rats fed high sucrose or glucose diet. All molar teeth were extracted either prior to or following oral challenge with strain 6715. In certain instances this procedure was supplemented with amputation of the incisors and disinfection of the remaining incisor surface area with iodine solution. The results suggest that in rats the colonization of S mutans on the teeth is required for its presence in the intestinal canal as well as the mouth. The significance of the observations has been discussed.

Animals↗
PubMed1977

[Cisternography with 111Indium-DTPA (author's transl)].

The experiences of more than 200 cisternographic examination with 111Indium-DTPA are reported. The radiopharmaceutical was tolerated without adverse reactions and the suboccipital intrathecal injection more appropriate than the lumbar. With 111In-DTPA excellent scans were obtained up to 48 h after application. 111In is compared with other radiopharmaceuticals for cisternography. The cisternography remains valuable as an additional examination of pneumencephalography and cranial computerized tomography.

Brain Diseases↗
PubMed1976

[Nosology of schizophrenia (author's transl)].

Schizophrenia and its variations, the different concepts and criteria for the diagnosis of schizophrenia and the possibilities of "prognostic diagnosis" at the beginning of the disease are discussed. There is only a differential typology between schizophrenia and cyclothymia and no sharp differential diagnosis. The numerous attempts to separate the two large groups of disease types are critically reported. Uncharacteristically pure residual states which leave the center of personality intact are more frequent than typical schizophrenic personality changes; the majority of schizophrenic patients are socially cured after more than two decades. More recent investigations on the course lead to an approximation to the concept of the "homogenous psychosis" and compel a greater observation of the "stratification rule" in the diagnosis.

Cyclothymic Disorder↗
PubMed1976

[Evidences for the somatosis hypothesis of schizophrenia (author's transl)].

The hypothesis of a hereditary mutative enzyme disturbance which becomes effective via biochemical, for peristatic influences susceptible cerebral mechanisms, is compatible with all findings. The evidences are stated. Schizophrenia is a predominantly hereditary disease. The findings of the family and twin research confirm this statement, in particular the difference of the concordance figures with monovular and binovular twins, furthermore the existence of substrate-close basic disturbances with their analogies to cerebro-organic symptomatology, the frequency and structure of pure residual syndromes and the results of clinical-encephalographic correlation examinations. Slightly marked internal brain atrophies which can be demonstrated by pneumo- and echoencephalogram can be correlated with the "pure defect" which is the most frequent residual syndrome of schizophrenic diseases. A geneticly conditioned cerebral enzyme defect can cause an atrophy in the region of the limbic system; however, a merely functional decompensation of a cerebral enzyme disturbance, without atrophy is imaginable in a part of the schizophrenia and cyclothymia. In certain active basic stages the EEG reveals abnormal rhythms ("parenrhythmiae"), which also allow a topical classification to functional structures of the limbic system. The non-characteristic organic "pure potential reduction" is irreversible, the typically schizophrenic syndromes potentially reversible. Basic disturbances and basic syndromes are in prodromes and outpost syndromes prior to manifestation of psychosis and after their remission the actually primary symptoms. The typically schizophrenic syndrome results from the amalgamation of the basal functional disturbance with the "anthropological matrix", partly provoked by - also non-specific - stress factors. The substrate-close basic symptoms: coenesthesias, perception disorders, zentral-vegetative dysregulations and cognitive primary disturbances can be seen as expression of a pathologically altered cerebral function in the region of the integrative system which is responsible for the regulation of the cerebral filter and protection processes.

Atrophy↗
PubMed1976

[Comparison between myelography and discography for lumbar prolapsed intervertebral discs (author's transl)].

For the diagnosis of lumbar P.I.D. discography is much superior to myelography. The risks of both techniques are the same, but the side-effects of discography are clearly less. Higher lesions remain a problem if they do not show up neurologically (s. the prolapsed disc at L 2/3). Here segmental blocking, posterior gaping of the intervertebral space and displacement of the dural sac show clearly the posterior prolapse. In the standard discogram of the lower 3 discs it would have been missed. In spite of this our present experience with lumbar discography is so positive, that we are about to test a long term series, whether and to which extend discography could replace myelography in cases where there is no hint at a space-occupying lesion, other than a disc or whether the order of these investigations should be reversed.

Humans↗
PubMed1975

[Late schizophrenia (author's transl)].

The designation "late schizophrenia" is used with reference to M. Bleuler. Of 502 cases of schizophrenia admitted to the mental hospital of the university of Bonn from 1945-1959 and later catamnestically examined, 14% were taken ill after age 40. Including the deceased, the percentage increases to 17.1 (110 of 644 cases). The onset of disturbance could be ascertained with 50% occurring equally between age 40-44 and age 45-59. Late schizophrenia became manifest after age 50 in 24. 3% and in 3.1% after age 60. The average period of observation was 17.8 years, and 20.7 years including prodromes. In 42.8% prodromes and/or signs in advance could be traced. Females predominated (64.3%). Syntonic personalities were markedly more frequent (49.3%), psychopathic primary personalities less frequent than in other schizophrenias in the first half of life. With regard to premorbid intelligence or hereditability no differences could be found. Psychic-reactive actuation (31.9%) was not significantly more frequent than in the group as a whole (25%). Not even by social factors (social class of parental family, bachelorhood rate, childlessness, and late marriage) could late schizophrenia be reliably distinguished from other schizophrenias. The quota of initially dominating paranoid-hallucinatory (55.4%) and paranoid syndromes (23.2%) is markedly higher than in schizophrenia of the first half of life, depressive moods (47.1%) and coenaesthesias (64.3%) less frequent. The final prognosis is - especially for women - more favorable, the rate of full remissions amounting 30%; 35% showed remissions to slight pure residual symptoms. All types of schizophrenic courses also occur in late schizophrenia; monophasic types are significantly more frequent, the two most prognostically unfavorable types are significantly rarer than in the group as a whole. The rate of social reintegration is with 64.3% higher and that of permanent hospitalization 10% lower than in the group as a whole. In view of the identity of late schizophrenia with all other schizophrenias, the same principles have to be applied to therapy and rehabilitation.

Adult↗
PubMed1975

A long-term follow-up study of schizophrenia: psychiatric course of illness and prognosis.

A systematic psychiatric follow-up study of 502 schizophrenics was carried out using the same well-defined criteria to evaluate the patients throughout the investigation. After an average course of disease of 22.4 years, 22.1% of the patients showed complete psychopathological remission, 43.2% had non-characteristic types of remission and 34.7% suffered from characteristic schizophrenic deficiency syndromes. At the time of the last follow-up investigation, 86.7% of the patients were living at home, while 13.3% were permanently hospitalized. Of the entire sample, 55.9% were found to be "socially recovered". Higher education, psychoreactive provocation, depressive traits, perception of delusions, catatonic agitation, non-characteristic thought disorders and symptoms of depersonalization at the onset of the illness tended to carry with them a favorable prognosis. On the other hand, low intelligence, abnormal primary personality, premorbid disturbances in social behavior, broken homes, prolonged prodromal stages, pneumoence-phalographically measurable atrophic or dysplastic changes in the brain ventricles as well as somatic and auditory hallucinations and predominance of hebephrenic symptoms at the onset of the illness tended to lead to an unfavorable prognosis. The principle of the basic reversibility of typical schizophrenic symptoms and the extensive irreversibility of the non-characteristic defect is important for the psychopathological and social long-term prognosis.

Adolescent↗