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Biomedical subjects

G Hoppe

Publications and source records attributed to G Hoppe.

At least 37 records · Page 2Linked to original sources
PubMed1987

Oral contraceptive-induced changes in plasma lipids: do they have any clinical relevance?

The plethora of published studies investigating oral contraceptive pill (OC)-induced changes of various plasma lipids and their ratios together with repeated reviews of these studies in the literature, are all based on the assumption that OC-induced favourable or unfavourable lipid profiles decrease or increase a pill-associated cardiovascular risk. Some authorities have been led to recommend choice of pill formulations based on such changes of plasma lipids. In a combined review of relevant cardiovascular and OC epidemiological studies no evidence is found for these assumptions and recommendations. There is no evidence of OC-induced atherosclerotic disease, and pill-induced changes of plasma lipids within normal limits are therefore probably without any clinical relevance. Profound changes towards a so-called favourable plasma lipid profile may, on the contrary, be detrimental in terms of pill-associated cardiovascular events.

Contraceptives, Oral↗
PubMed1981

[Investigations on the dependency of hemagglutination inhibition titers against rubella virus on the number and quality of antibody molecules (author's transl)].

The number (A) and quality (K) of rubella virus antibody molecules has been determined for human sera obtained at graded time intervals after rubella infection or vaccination. Tests were carried out by use of a previously described technique (9) and the results were compared with the rubella HI titers found. Sera obtained within 59 days after onset of rash or vaccination of previously seronegative persons were found to contain antibody molecules of lower quality than did sera obtained at later time intervals. Sera obtained after vaccination of seronegative humans contained much smaller numbers of antibody molecules than did sera obtained after rubella infection. With the exception of sera obtained within 59 days after onset of rash, no significant differences in the number of antibody molecules per HI unit were found. The HI titers depended with this exception primarily on the number and not on the quality of antibody.

Antibodies, Viral↗
PubMed1980

Description of a technique for the determination of the concentration and quality of rubella virus antibody molecules and experience with testing sera from humans with recent and past rubella infection.

The method of equilibrium filtration described by Fazekas and Webster (7, 8) for the determination of the concentration (A) and quality (K) of influenza virus antibody molecules was modified in order to permit such determinations to be made for rubella virus hemagglutination inhibiting (HI) antibodies. The technique was used for determining the A and K values of humans with recent and past rubella infection. Sera from patients collected within 59 days after onset of rubella rash were found to have larger K values than found for sera collected therafter or from persons with past rubella infection. The difference in K values was found not to depend on the levels of IgM rubella antibodies. Therefore, sera from persons with recent and past rubella infection can be distinguished by use of this technique independently from the relative concentrations of rubella IgM and IgG HI antibodies.

Antibodies, Viral↗