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Biomedical subjects

G Hole

Publications and source records attributed to G Hole.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Diurnal variations in hospitalised depressive patients during depression and when healthy (author's transl)].

Diurnal variations during the depressive phase and healthy periods were investigated in 84 hospitalised depressive patients of different nosological diagnosis. The occurrence of different rhythm-types in this population led to the conclusion that depression induces rhythmicity: those belonging to the arhythmic group when healthy showed significant increase in rhythmicity when depressed, predominantly the classical form of diurnal variation (morning with improvement toward evening). Age and sex were found to be important factors determining diurnal variation. In the course of hospitalisation, the type of diurnal rhythm remained individually constant.

Age Factors↗
PubMed1976

[The process of decision in the categorical-nosological classification of depressives syndromes and its importance for the concept of therapy (author's transl)].

Proceeding from the fact psychiatric thinking is very much based on fixed categories we try to study the rigidity of the traditional system of nosological classification of the depressive syndromes. Though an increasing number of colleagues advocates a multiconditional or complex analysis of depressive states in theory and praxis, and in their majority is convinced of an involvement of both endogenous and psychogenic factors in most depressions, this conviction seems not to influence the use of those traditional categories. A classification of endogenous and psychogenic depressions corresponding to the accustomed diagnostical schemes is being applied. The general acceptance of this coercion to an absolute alternative diagnosis reveals us the reign of traditional categories in our mental attitude. Thus, we must aspire to create denotations for a nosological main-group of depressive states that will be interpreted multi-conditional. Such a step would have extensive consequences for our treatment concepts. The traditional alternative diagnostics still suggest the possibility of an alternative therapy and thus mainly tend to a single-track accentuation in either pharmacological or psychological therapy. Provided a better categorial and nosological differentiation of the depressive spectrum, the construction of integrated plans of therapy could be achieved in a more differentiated and better founded way.

Depression↗
PubMed1975

Monoamine oxidase and free tryptophan in human plasma: normal variations and their implications for biochemical research in affective disorders.

A methodological study of healthy subjects was conducted to investigate factors influencing plasma free tryptophan and platelet monoamine oxidase (MAO) activity. The following changes were found during the menstrual cycle: free tryptophan was lower during the "ovulatory" phase than during the "premenstrual" phase, MAO activity was 20% lower during the "premenstrual" phase as compared with the "neutral" phase (days: menses-24 to -1). During pregnancy MAO activity was also lower than the values found six weeks postpartum. MAO activity in women was significantly higher than in men and exhibited greater variability. A circadian rhythm for free tryptophan was observed (minimum at midday, maximum at midnight). No diurnal variation in MAO activity could be established. Preliminary data from untreated endogenous depressive patients showed no difference in free tryptophan concentrations at 8 a.m. or 4 p.m. from control values.

Adult↗