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Biomedical subjects

G Hohlbrugger

Publications and source records attributed to G Hohlbrugger.

24 records · Page 2Linked to original sources
PubMed1982

Angiotensin I converting enzyme in rat testis, epididymis and vas deferens under different conditions.

Angiotensin I converting enzyme (ACE) was found in the testis, epididymis and vas deferens of rats. In tissue specimens without a prior washout of seminal fluid the highest specific ACE activity was measured in the testis. The enzyme activity was significantly lower towards the end of the excurrent ducts, suggesting that the enzyme is synthesized in the testis and secreted into the seminal fluid there. An ACE inhibiting substance may be secreted by the epididymal epithelium. Enzyme synthesis and enzyme inhibition are probably under simultaneous endocrine control. In-vitro inhibition, pH- and temperature-dependence of gonadal ACE correspond with that of lung and blood plasma. However, the physiological function of the enzyme on sperm motility and fertility remains unsolved.

Animals↗
PubMed1982

[Bladder injuries--diagnosis, acute care and late results].

From 1962 up to 1980 82 bladder injuries have been diagnosed and treated at the University Hospital Innsbruck, Department of Urology. Excluding the iatrogenic bladder trauma, we report on the extraperitoneal and intraperitoneal rupture as well as the contusion. Diagnosis and acute management are emphasized. The effectiveness of the diagnostic and therapeutic regimen is supported by the lack of major complications and by the encouraging late results.

Diagnosis, Differential↗
PubMed1981

Effects of Urol on isolated neuromuscular preparations of guinea pig and rat urogenital tracts (ureter, detrusor vesicae and vas deferens).

Urol--a compound of extracts from rad. Rubiae, sem. Ammeos visnagae, herb. Virgaureae, rad. Taraxaci and aescin - induced changes in the mechanical activity (isotonic registration) of guinea pig and rat ureter, detrusor and vas deferens preparations when applied at concentrations of 10 ng to 100 microgram/ml. Low concentrations (10 ng to 1 microgram/ml) had an inhibitory effect on the spontaneous mechanical phasic activity in about half of the ureter preparations and a stimulatory effect on the remaining preparations; higher concentrations (1-100 microgram/ml) had a predominantly inhibitory effect. Urol acted similarly on detrusor preparations; it inhibited (up to 30% at 10 mg/ml) or stimulated the contractile responses after nerve stimulation (10 Hz, 0.3 ms, 3 s); it had a purely inhibitory effect on the contractions of vas deferens after nerve stimulation and had an inhibitory effect on X-ray-induced contractions in detrusor muscle preparations. The effects of Urol were observed at therapeutically relevant concentrations (about 1-10 microgram/ml). The nonuniform effects of Urol on urinary tract preparations suggest a reason for the differences in therapeutic response observed in clinical trials.

Animals↗
PubMed1980

A micropuncture study of transepithelial water reabsorption in rat ductuli efferentes.

Micropuncture techniques were used to study transepithelial water reabsorption in single tubular sections of rat ductuli efferentes in vivo and in situ. Fluid reabsorption was found to be secondary to an electrolyte transport process. It was completely abolished by intraluminal application of 10(-4) M amiloride and by an elevated local temperature of 38 degrees C. The fluid reabsorption rate was modified by the intraluminal electrolyte concentration, whereas various local temperatures from 37 degrees C to room temperature had no effect. This finding led to the conclusion that the function of the ductuli efferentes may require temperatures lower than body temperature, which is in accordance with the well-known behavior of mammalian testes. It was further suggested that the described fluid reabsorption leads to concentrations of spermatozoa and of substrates which spermatozoa may need to develop and mature.

Absorption↗
PubMed1977

The early phase of experimental acute renal failure. II. tubular leakage and the reliability of glomerular markers.

Experiments were designed to determine whether leakage of substances across the tubular epithelium, which are impermeant in the normal kidney, falsifies the measurement of glomerular filtration rate in acute renal failure. Permeability to those substances most commonly used for filtration rate determination, polyfructosan, inulin and ferrocyanide, was estimated by measuring their recoveries following perfusion through various nephron segments in haeme pigment, ischaemic and nephrotoxic models of acute renal failure. Late proximal recovery of 14C ferrocyanide was only marginally decreased compared to controls, by a maximum of 6%. Distal recovery of polyfructosan, 14C and 3H inulin were depressed somewhat more, by a maximum of 11%. Urinary recovery of 14C inulin was reduced by only 15% in kidneys showing severely restricted renal function. It is concluded that tubular leakage is not a feature of significance in the early phase of moderate acute renal failure, that ferrocyanide and inulin are reliable markers for the determination of nephron filtration rate and water reabsorption, and that the reduction in whole kidney inulin or polyfructosan clearance reflects primarily a reduction in glomerular filtration rate.

Acute Kidney Injury↗