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Biomedical subjects

G Hirsch

Publications and source records attributed to G Hirsch.

At least 37 records · Page 2Linked to original sources
PubMed1993

Steroid psychosis: a cause of confusion on the acute spinal cord injury unit.

The use of glucocorticoids has long been known to be associated with a number of side effects. The current use of high-dose methylprednisolone in spinal cord injured patients puts this population at increased risk. In particular, the risk of acute psychotic reactions is increased because it is a dose response relationship. Conservative estimates report an incidence of 5.7%. These reactions place the patient at increased risk of further spinal cord injury and worsening neurologic deficit. We present two cases of possible steroid psychosis in which the mental status changes did indeed place the patients at risk of further injury.

Adolescent↗
PubMed1992

Contrast medium injected into juvenile bone cysts to analyze interior morphology and guide intracavity corticosteroid treatment.

In connection with treating juvenile bone cysts with intracavital corticosteroid injections, the interior cyst anatomy was analyzed at cystography in 13 children aged 4 to 15 years. Only 4 children had a true unicameral cyst; the others had 2 or more cysts or had compartments with free or restricted communication to the main cyst. Cysts and compartments which had not been reached by steroids may continue to grow. Optimum treatment may therefore require injections at different sites guided by cystography. Neither conventional criteria of cyst activity nor repeated bone scintigraphy 3 months after treatment could predict whether the treatment would lead to final healing.

Adolescent↗
PubMed1991

A phase II study of idarubicin in the treatment of measurable gastric cancer.

Idarubicin is one of the new anthracycline analogues. It has a higher therapeutic index than either doxorubicin or daunorubicin in a variety of murine leukemias and solid tumors. The authors performed a multicenter Phase II trial of idarubicin in patients with advanced gastric cancer. Seventeen patients with measurable metastatic disease were entered into the trial and treated with idarubicin at a starting dose of 15 mg/m2. This dose was escalated or reduced according to toxicity. There were no documented responses. The dose-limiting toxicity was myelosuppression. These data did not compared favourably with the data on doxorubicin in the treatment of gastric carcinoma. A conclusion could not be reached on whether idarubicin has minimal activity in the treatment of gastric carcinoma.

Adenocarcinoma↗
PubMed1991

Relationship between performance on lumbar dynamometry and Waddell score in a population with low-back pain.

A prospective, blinded cohort study was performed to investigate the relationship between biomechanical variables measured during lumbar dynamometry and several psychological tests and measures of nonorganic pain behavior. Eighty-five men, aged 18-60 years, who had had low-back pain for longer than 5 weeks participated in the study. Nonorganic pain behavior was measured with the Waddell score, and lumbar function was measured with the Isostation B-200 Lumbar Dynamometer. Two brief psychological tests, the Coopersmith Self-Esteem inventory and an analog self-rating of wellness, were also administered. Relationships between biomechanical variables and psychological tests were calculated with the t-test, the Pearson r correlation, analysis of variance, and multiple step-wise logistic regression. Patients who exhibited excessive illness behavior (Waddell Scores 3-5) performed significantly worse (P less than .01) on almost all biomechanical variables. The Coopersmith Self-Esteem Score and "feelings" score had a slightly weaker but still significant correlation with motor performance. The results suggest that poor performance on biomechanical testing in this population may be a form of abnormal illness behavior and thus may not accurately reflect organic alterations of neuromusculoskeletal function.

Adult↗
PubMed1990

Appearance during chick embryogenesis of vitamin D-dependent calcium-binding protein (calbindin-D28K).

The appearance of the vitamin D-dependent calcium-binding protein (calbindin-D28K) in embryonic chick tissues was determined using a sensitive immunohistochemical assay to elucidate the possible role of calbindin-D28K during embryogenesis. This protein first occurs in renal, cerebellar and intestinal cells during the final stages of maturation and/or differentiation. It is during this period of their development that these tissues become functional. On the basis of our observations, we suggest that the onset of cell function may be coupled with the appearance of calbindin-D28K.

Animals↗
PubMed1986

Training graduate students in parent conference skills.

Twelve graduate students were trained in three categories of parent conference skills: communicating diagnostic information, communicating recommendations, and organizing the conference and interacting with parents. Training done individually with each student consisted of written programmed learning materials plus oral practice. Training effects were measured during role-play and actual parent conferences. Training effectiveness was assessed with a multiple baseline design across three skill categories. Eleven of 12 students exhibited significant skill acquisition and nine generalized skills to an actual parent conference. Professionals and parents of developmentally delayed children attested to the importance and effectiveness of the training program. Results demonstrated that parent conference skills can be operationalized, trained, and generalized to actual conferences.

Adult↗