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Biomedical subjects

G Hildenbrand

Publications and source records attributed to G Hildenbrand.

31 records · Page 2Linked to original sources
PubMed1981

[Study of the concentration of triiodothyronine, thyroxine and thyreotropin in blood serum of euthyroid children (author's transl)].

Concentrations of triiodothyronine, thyroxine and thyreotropin were determined using the radioimmunoassay method in blood serum of 369 (male = 231, female = 138) euthyroid children. Beyond the newborn age no significant difference were found for the triiodothyronine and the thyreotropin concentration. Compilation of the values resulted in a physiological triiodothyronine concentration of 1.96 +/- 1.11 (1s) ng/ml -3.02 +/- 1.71 (1s) nmol/l- and in a thyreotropin concentration of 1.50 +/- 1.48 (1s) microunits/ml for infants, children and juveniles. In opposition to these results the thyroxine concentration showed a clear age-specific dependence. The thyroxine concentration decreased continuously from the infant age- (120 +/- 27 (1s) ng/ml, 154.8 +/- 34.8 (1s) to the juvenile age (69.1 +/- 16.4 (1s) ng/ml, 89.1 +/- 21.2 (1s) nmol/l).

Adolescent↗
PubMed1980

A quantitative study of free amino acids in eccrine sweat collected from the forearms of healthy young men during sauna bathing.

Using ion-exchange column chromatography we measured the free amino acids in eccrine sweat collected from the forearms of 20 healthy young men at intervals of 15, 30, and 45 min during sauna bathing. In comparison with the amino acid concentrations determined after 15 min of sweating (100%) a significant and uniform decrease occurred in the concentrations of all amino acids examined after a further 15 min (65%), with a further decrease after another 15 min (45%). These results indicate that either the mechanism of excretion of amino acids in the secretory cells of the eccrine sweat glands, or the reabsorption of amino acids by the ductular cells, or the combination of both mechanisms are similar for all the amino acids examined here.

Adult↗
PubMed1980

Methodological implications of testing anaerobe susceptibility to cephalosporins (cefazolin, cefamandole, cefoxitin).

By simultaneously performing broth dilution, agar dilution, and agar diffusion tests with Bacteroidaceae and Peptococcaceae, the influence of methodology upon the outcome of susceptibility testing to cefazolin, cefamandole and cefoxitin was studied. With beta-lactamase positive and negative Bacteroidaceae, the results of the broth dilution and agar dilution tests were in good agreement for cefoxitin. However, when tested with cefaxolin and cefamandole, beta-lactamase positive Bacteroides strains had mostly high broth dilution MICs and relatively low agar dilution MICs. The statistical analysis of the relationship between zone size and broth dilution or agar dilution MICs frequently showed lack of stochastic linearity or relatively low correlation coefficients.

Bacteroidaceae↗
PubMed1978

[The value of radiographic examinations of the thorax in acute myocardial infarction (author's transl)].

The degree of pulmonary congestion seen on chest radiographs taken in the intensive care unit was compared with the end-diastolic pulmonary artery pressure in 65 patients with recent transmural myocardial infarcts without cardiogenic shock. There was good correlation between the radiographic appearances and the end-diatrolic pulmonary artery pressure, so that the severity of left heart insufficiency could be diagnosed radiologically at an early stage. Errors were due to the time interval which must pass before the radiographic appearances approximate the haemodynamic changes. This resulted in a diagnostic "phase lag" (following a rise in end-diastolic pulmonary artery pressure) or in a post-therapeutic "phase lag" (after a fall in end-diastolic pulmonary artery pressure). Repeated examinations allow one to recognize changes in the haemodynamics. One should pay particular attention to the features of pulmonary venous and pulmonary arterial hy

Acute Disease↗
PubMed1977

[Intrauterine devices for contraception? Results of an inquiry conducted in the BRD in 1976].

The results of the 1098 responses to a questionnaire show a remarkable increase in the use of intra-uterine devices (IUD) as a method of contraception (especially in the last 3 years) in the FRG too. The main reasons for the insertion of IUD were specified as "incompatibility" with the pill or "weariness induced through constant use of the pill". IUD are also used by nulliparae. At the moment T-shaped models containing copper are most popular. The majority of insertions are performed without general anaesthesia. The optimal length of time for wearing an IUD is considered to be 2 years or more. The foremost reasons for removal of IUD are bleeding or pain. Failures (pregnancies) however, are rather frequently recorded. Most gynecologists remove the IUD if pregnancy has occurred and in this case only few of them try to maintain the pregnancy on the patients request. In 1976, the majority of gynecologists attended patients composed of 40 : 1 users of the pill : users of IUD. Numerically speaking therefore, IUD are the method which actually takes second place. In our opinion however, if attention is paid to indications and contra-indications and to the necessity for intensive education of the patient, IUD are a real alternative to the pill and to the increasing use of any type of female sterilization.

Contraception↗
PubMed1977

The bioavailability of phenytoin.

The bioavailability of three commercial products of phenytoin (Epanutin, sodium salt; Phenhydan, calcium salt; Zentropil, free acid) was studied relative to a standard solution of sodium phenytoin. Each preparation was given for 14 days in a daily dose of 300 mg according to a cross over design. The three brands tested were equivalent as to their bioavailability with respect to plasma concentrations during one dosing interval, the area under the plasma level time curve, the time of peak plasma concentration, and the urinary excretion of the primary metabolite. Therefore, these phenytoin brands are bioequivalent and exchangeable for antiepileptic treatment. The standard solution of sodium phenytoin had a higher bioavailability as compared to the commercial products.

Adult↗
PubMed1977

[Central register and combined study of testicular tumors (author's transl)].

To successfully combat cancer, research needs to be based on prospective investigations and central collation of data. An initial report is presented concerning one such investigation that has been in progress since September, 1976: "central register and combined study of testicular tumors--Bonn." The aims are to collate epidemiologic data, achieve a standardization of the stages of the cycle of the seminiferous epithelium and of classification, on the model of the WHO, as well as to attain maximum efficiency of diagnosis and therapy. Fourteen participating clinics in the German Federal Republic, Austria, and Switzerland, and 70 submissions of data up to the 1st of March, 1977, amply justify the efforts so far expended and encourage us to solicit the cooperation of previous nonparticipants.

Adult↗
PubMedDate not supplied

[Premature termination--a multifactoral phenomenon].

Twelve drop out cases in psychodynamic short term therapies according to the focus of cyclic maladaptive pattern by Strupp and Binder (CMP 1984) are reviewed regarding initial diagnostics, tape-recorded therapy sessions, and supervision records. Predictors of premature termination of therapy such as initially rated patients' therapy motivation, narcissistic personality traits, but also characteristics of interpersonal behavior of both patient and therapist are examined and discussed. Particularly important are the therapeutic alliance and narcissistic patients' difficulties to relate personally to their therapists instead of enacting projective dynamics of idealization and devaluation. Therapists frequently tend to respond to them by subconscious display of hostile countertransference. Four patterns of dynamics of therapy drop outs are described.

Adult↗