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Biomedical subjects

G Heynen

Publications and source records attributed to G Heynen.

89 records · Page 5Linked to original sources
PubMed1975

[The circulating forms of human calcitonin].

It is demonstrated for the first time that there are at least two forms of immunoreactive CT in serum: the first has the same physico-chemical properties as synthetic CT whereas the second one has a higher molecular weight than synthetic CT, close to the molecular weight of serum albumin. Such heterogeneity was found in the sera of normal subjects and in the sera of patients suffering from several diseases. Results suggest that the percentages of these two forms vary from one serum to another.

Calcitonin↗
PubMedDate not supplied

Effects of salmon calcitonin on blood glucose and insulin levels under basal conditions and after intravenous glucose load.

A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the blood sugar (p less than 0.01) and a highly significant decrease in the serum insulin levels (p less than 0.01). After intravenous glucose load, there was a decrease of the coefficient of glucose utilization and of the insulin response both of which were highly significant (p less than 0.01).

Adult↗
PubMedDate not supplied

Proteoglycan metabolism in isolated chondrocytes from human cartilage and in short-term tissue-cultured human articular cartilage.

The effect of piroxicam on proteoglycan metabolism of human cartilage cells was investigated in two in vitro models. Cells or tissue samples were obtained from six different donors. Piroxicam levels used in the test systems ranged from 2 to 6 micrograms r/ml and were comparable with serum concentrations in humans after oral intake. Piroxicam increased the synthesis rates of proteoglycan in some batches of isolated and monolayer-cultured chondrocytes and in tissue-cultured articular cartilage. The fact that this increase in the synthesis of proteoglycan was restricted to some of the donors whereas isolated cells or tissue samples from other individuals remained unaffected illustrates the heterogeneity of different human donors. Depression of proteoglycan synthesis in the presence of the drug was not observed.

Cartilage↗
PubMedDate not supplied

[Thoughts about 20 cases of hyperparathyroidism (author's transl)].

The analysis of 20 personal cases of parathyroid hyperplasia or adenoma suggest the following conclusions: 1. The importance of dosage of the parathormone is a decisive factor of the diagnosis and yields data: a) in relation with the volume of the adenoma; b) that return to normal 24 hours after resection; c) that constitute the proof of complete resection. 2. The little utility of the diagnosis of location bij means of elaborate paraclinical exams. The authors show false positive angiograms. Only the inspection of the four parathyroids and of the main heterotopic areas is a valid means of disclosing the lesions responsible of the hyperparathyroidism. It is essential to operate with a skilled pathologist who will read frozen sections.

Adolescent↗
PubMedDate not supplied

[Variations in parathormone serum levels during treatment of Paget's disease with calcitonin of human or salmon origin (author's transl)].

Biological effects of increasing doses of human and salmon calcitonin (CT) have been studied in 17 patients suffering from Paget's disease of bone. Results show a dose response relationship on indirect indices of bone turn-over. The plateau phenomenon occurs with both CT and more rapidly with the lower dosage. There is also a transient increase in parathyroid activity during the period of time when bone turn-over is decreasing. Calciuretic effect was more pronounced with salmon than with human CT.

Alkaline Phosphatase↗