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Biomedical subjects

G Hermann

Publications and source records attributed to G Hermann.

At least 109 records · Page 6Linked to original sources
PubMed1991

Nonpalpable ductal carcinoma in situ versus infiltrating carcinoma of the breast--can they be differentiated by mammography?

The radiologic patterns of 193 consecutive women with nonpalpable breast carcinoma were evaluated. The results were correlated with patient age and with the histopathologic diagnosis. Of the 193 women in the study, 135 (70%) were older than 50 years; 102 women had ductal carcinoma in situ, and 67 (62%) of them were over age 50; the remaining 91 women had infiltrating carcinoma, and 73 (80%) of these patients were older than 50 years. Of the 58% of women who presented with microcalcifications, 75% had ductal carcinoma in situ and 25% infiltrating carcinoma. Of the 36% of patients who presented with a mass, 87% had infiltrating carcinoma and 90% were over age 50. Six percent presented with a mass with microcalcifications; 75% of these masses were found to be infiltrating carcinoma. Most of the masses were infiltrating carcinoma, and of these 90% were high-density masses. The small number of masses representing ductal carcinoma in situ were proportionately of low density.

Adult↗
PubMed1991

The surgical management of superficial infections caused by atypical mycobacteria.

We have recently treated four patients with atypical mycobacterial skin infections. Two patients were infected with Mycobacterium smegmatis after self-injection with a veterinary-grade anabolic steroid. To our knowledge, this complication has not been previously described. The other patients had steroid-dependent asthma and lower extremity infections involving M. kansasii and M. chelonei after minor household trauma developed. Atypical mycobacterial skin infections may be seen as chronic ulcerations with violaceous edges, rolled margins, and significant subcutaneous necrosis. An indolent course and the clinical appearance may aid in diagnosis. In our experience, limited incision and drainage or dressing changes fail to eradicate these infections, even when accompanied by appropriate antibiotic therapy. Successful treatment requires aggressive debridement of all infected subcutaneous tissues and skin. Split-thickness skin grafting was successfully used to cover large wounds. Grafting did not appear to foster recurrent infection.

Anabolic Agents↗
PubMed1990

Surgery for nonpalpable breast lesions.

Nonpalpable lesions detected on mammograms were localized in 475 women between 1976 and 1988 by means of the spot method. A malignant neoplasm was noted in 149 patients (31%), including 69 (33%) of 206 with clusters of microcalcifications, 16 (41%) of 39 with calcifications associated with densities and 64 (28%) of 230 with nonpalpable masses. Infiltrating lesions were present in 89 (60%) of 149 patients. Among women with infiltrating lesions who had axillary dissection, 14 (21%) of 67 had positive nodes. In younger women, microcalcifications were more likely to represent neoplasms, masses frequently represented invasive tumors. Among patients with invasive malignant neoplasms who had calcifications, 39% had positive axillary lymph nodes. Spot localization, rather than monitoring, seems appropriate in young women with microcalcifications suggestive of malignant neoplasms and older patients with nonpalpable masses to achieve earlier and more effective treatment of biologically significant occult neoplasms.

Adult↗
PubMed1990

Case report 623. Osteitis condensans of the left clavicle (OCC).

A case of OCC in a 35-year-old woman is presented. Proof was obtained by open biopsy. This rare entity is benign and its etiology is still obscure. No definite association with osteitis pubis or osteitis condensans ilii has been reported. The involvement of the clavicle is invariably unilateral. The clinical and radiographic characteristics of this benign condition have been discussed and the differential diagnosis has been considered. Consideration should be given to the concept that if the imaging features are characteristic, as in this case, biopsy may not be necessary.

Adult↗
PubMed1990

Case report 588: Intracortical chondroma of the left femur.

A case of intracortical chondroma in the left femur in a 22-year-old man is presented. Proof was obtained by open biopsy. The issue of periosteal vs intracortical chondroma was discussed in depth, with emphasis on the radiographic appearances. The differential diagnosis of this benign intracortical lesion was also included. The histopathologic characteristics of this intracortical chondroma were described and a possible explanation for the unusual location of the cartilage lesion within the cortex was considered.

Adult↗
PubMed1990

Nonpalpable breast masses: radiologic predictability of malignancy.

Of 568 nonpalpable breast lesions detected by screening mammography 242 proved to be noncalcified masses; biopsy showed 165 to be benign and 77 malignant. The lesions were evaluated with respect to contour, radiographic density and size. Of the malignant lesions 90% were infiltrating carcinomas, 88% of which had an indistinct contour and were of moderate to high density. Of the benign lesions 40% of those with an indistinct contour demonstrated high radiographic density. Low-density, distinct masses were all benign. There was no correlation between the size of the lesion and whether it was malignant.

Aged↗
PubMed1990

Atypical radiographic appearances of tuberculous granulomas of bone.

We present four adults with tuberculous granulomas of bone. In three patients the granuloma involved the end of a long bone. The vertebral body and the right pedicle of the 10th thoracic vertebra were involved in the fourth patient. In all four the adjacent joint or the disk space was spared; hence the lesions mimicked bone neoplasms. Sclerotic changes, periosteal reaction and sequestration were present in three patients. Three of the four patients were not white. Since histologic specimens may not reveal mycobacteria, radiologists should alert orthopedic surgeons to the need to obtain material for culture at the time of biopsy of lesions that might be unusual manifestations of skeletal tuberculosis.

Adult↗
PubMed1990

Case report 603. Giant cell reparative granuloma of the distal end of right femur.

A GCRG of the femur in a 57-year-old man was described. He had undergone local radiotherapy and systemic chemotherapy for T-cell lymphoma of the jaw and scalp diagnosed 4 weeks previously. Since radiologically the lesion suggested an aggressive process, malignant lymphoma was the most probable preoperative diagnosis. In the differential diagnosis giant cell tumor, brown tumor of hyperparathyroidism, benign fibrous histiocytoma, and malignant fibrous histiocytoma were discussed in further detail. This histologically documented case of GCRG of the femur without any underlying process appears to be the first case reported in a long bone. It is unclear if the reparative process was primary or represented a reaction of the host bone to lymphoma which had completely responded to chemotherapy.

Diagnosis, Differential↗
PubMed1990

Case report 621. Multiple myeloma (IgD) in a 28-year-old woman.

A 28-year-old woman with IgD myeloma was described. The patient presented with pain in the anterior wall of the chest, and tenderness over the ribs, thoracic spine, and right shoulder. A radionuclide bone scan showed increased uptake along the costochondral junctions, ribs, and shoulders, with the diffuse uptake in the costochondral junction being typical for costochondritis. Skeletal survey revealed small lucencies in the ribs, humeri, and shoulders, characteristic of MM. The patient's young age made the diagnosis of MM unlikely. The scintigraphic finding, typical of costochondritis, must be an extremely unusual pattern in MM since we were unable to find a similar case in the literature. It is speculated that MM may have been induced by chemical exposure.

Adult↗