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Biomedical subjects

G Hasselgren

Publications and source records attributed to G Hasselgren.

At least 37 records · Page 2Linked to original sources
PubMed1997

Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study.

BACKGROUND: Does profound acid inhibition by continuous infusion of omeprazole for 72 h reduce further bleeding in elderly patients with peptic ulcer bleeding (PUB)? METHODS: Three hundred and thirty-three patients > or = 60 years old with PUB were randomized to omeprazole (80 mg + mg/h) or placebo as continuous infusion for 72 h. From day 4 to 21 all patients received 20 mg omeprazole orally once daily. RESULTS: When evaluated on day 3, the primary variable 'overall outcome' (based on an ordinal ranking scale; see Study variables) (P = 0.017) and the secondary variables, surgery (P = 0.003), degree (P = 0.004) and duration of bleeding (P = 0.003) all favored the omeprazole group. Blood transfusions, need for endoscopic treatment, and mortality were not statistically different. On follow-up, by day 21, the mortality in the group initially receiving intravenous omeprazole was 6.9%, while the intravenous placebo group showed an extremely low mortality, 0.6%. CONCLUSION: Three days' infusion of omeprazole improved overall outcome and reduced need for intervention in PUB patients.

Aged↗
PubMed1993

Replacement of the os trapezium by polyurethane implants.

Twenty-five patients with arthrosis of the first carpometacarpal joint had the os trapezium replaced by a polyurethane implant (Tecoflex), and the results were evaluated after three years (range 28-47 months). There were three failures in which the implants had been removed because of dislocation with pain. The clinical results in the remaining 22 cases in terms of relief of pain and thumb function were comparable with previous series of silicone implants. Radiographic examination showed no signs of bone resorption or other unfavourable tissue reactions around the implants, but subluxation of the implants was seen in half of the cases. Implant subluxation might be caused by poor design of the implant or the limited amount of fibrous foreign-body reaction around the polyurethane material that resulted in less firm encapsulation than occurred around silicone implants.

Adult↗
PubMed1992

Tissue changes in immature dog teeth autotransplanted to surgically prepared sockets.

Tissue reactions in teeth autotransplanted to surgically prepared sockets were investigated by means of microangiographic, enzyme histochemical, and histologic methods. The experimental material consisted of 28 immature teeth in six mongrel dogs. In each tooth, approximately three fourths of the root was formed at the time of transplantation. Ten days after transplantation, a vascularized, well-stained connective tissue was observed in the apical area of the pulp. An ingrowing tissue had reached the pulp horn in all teeth 90 days after surgery. Odontoblasts were not found in any of the transplanted teeth. External root resorption was seen in all teeth but repair usually occurred approximately parallel to the ingrowth of new tissue into the pulp cavity. In a few teeth, however, advanced inflammatory root resorption was observed in cracks in the cervical area. When compared with the results of a previous study, the ingrowth of tissue occurred at a considerably slower rate than in teeth autotransplanted to natural sockets.

Animals↗
PubMed1992

The radiographic incidence of multiple roots and canals in human mandibular premolars.

The aim of this study was to investigate the incidence in mandibular premolars of multiple roots and root canals that could be demonstrated radiographically. The images of mandibular premolar teeth as seen on intraoral full-mouth radiographic surveys (547) taken with the paralleling technique were examined. In 99 patients (18.1%) there was at least one premolar tooth with either divided canals or roots. First premolars were involved in 15.7% of patients, and second premolars in 7%.

Bicuspid↗
PubMed1992

Peripheral inflammatory root resorption. A review of the literature with case reports.

External resorptions associated with inflammation in marginal tissues are many times misdiagnosed and confused with caries and internal resorptions. A lack of uniformity in nomenclature has added to the confusion. This paper reviews the literature and presents cases to illustrate a rational approach to diagnosis and treatment. A new name is suggested to better reflect the features of this type of root resorption: peripheral inflammatory root resorption.

Adult↗
PubMed1991

Bone grafting unnecessary in the treatment of enchondromas in the hand.

Twenty-eight consecutive patients with enchondromas in the hand skeleton had simple curettage of the tumor without bone grafting. The patients were followed-up with a radiologic examination mean six years (range from 0.5 to 16 years) after operation. Results were classified according to the amount of new bone formed in the cavity left after curettage. Results in fifteen patients with excellent bone formation were classified as grade one, in nine patients with good bone formation as grade two, and in four patients with scanty bone formation as grade three. There were no patients without new bone formation (grade four), nor were there any recurrences or postoperative fractures in this series. We conclude that simple curettage without bone grafting is a safe and effective treatment of enchondromas in the hand.

Adolescent↗
PubMed1990

Liquid silicone as a lunate prosthesis.

Eleven patients with lunatomalacia were treated by excision of the lunate and instillation of liquid silicone. The silicone vulcanised and formed an in-situ molded prosthesis. The patients were reexamined after a mean of 7.1 years. Four patients were pain-free and two had pain only at work; three had not been improved by the operation and two had undergone arthrodesis. The patients with good results all belonged to group IV pre-operatively. Surprisingly, no patient showed any sign of silicone synovitis, although all the prostheses except one had either fractured or deformed. The reasons for this are discussed and the indications for the operation established.

Follow-Up Studies↗
PubMed1989

Emergency pulpotomy: pain relieving effect with and without the use of sedative dressings.

Seventy-three teeth with acute irreversible pulpitis were subjected to emergency pulpotomies. After removal of the coronal portion of the pulp, a sterile cotton pellet or zinc oxide-eugenol cement was placed against the remaining pulp tissue. The cotton pellet was either dry or moistened with camphorated phenol, cresatin, eugenol, or isotonic saline. This gave six different groups of treatment following the pulpotomy. All teeth were sealed with zinc oxide-eugenol cement. By means of questionnaires, symptoms were recorded after the anesthetic effect was gone and also at 1, 7, and 30 days after treatment. A total of 70 patients (96%) reported pain relief. Three patients did not experience relief and returned for pulpectomy. After the first postoperative day, no pain was reported by any of the patients. The frequency of discomfort decreased from 11% 1 day postoperatively to 1% 30 days after the emergency treatment. There was no difference in recorded symptoms among the six treatment groups. Thus, removal of caries, pulpotomy, and sealing of the cavity apparently was a reliable means to relieve pain. The use of the various dressings did not contribute to the relief of pain.

Analgesics↗
PubMed1989

Craniomandibular disorders in chronic orofacial pain patients.

Forty-six patients with chronic orofacial pain were examined by a pain group consisting of specialists from different fields of dentistry. More than half of the patients presented a craniomandibular diagnosis. The pain had diminished or disappeared 1 year after treatment in 46% of the patients as a whole and in 39% of the patients with a craniomandibular diagnosis. Fifty-two percent of the patients with no relief of their chronic pain had a psychiatric diagnosis.

Adult↗
PubMed1988

Individualised restricted intraoral radiography versus full-mouth radiography in the detection of periradicular lesions.

The aim was to study the diagnostic yield of periradicular lesions using different combinations of periapical radiographs. One hundred patients were first examined clinically and then periapical radiographs were taken of teeth with clinical signs and symptoms. As a second step of the radiological examination, periapical radiographs were taken of teeth that were endodontically treated or had extensive cavities demonstrated by bitewing radiographs. Finally, these radiographs were supplemented to make up a full-mouth examination. Out of 226 periradicular lesions. 34% were indicated by the clinical symptoms, another 43% by the fact that the tooth was endodontically treated and an additional 13% by having an extensive cavity. The remaining 10% of the periradicular lesions were found only with the aid of the full-mouth examination. It is suggested that information from clinical examination and from bitewing radiographs of the whole dentition might be employed to select radiographs in order to detect periapical lesions.

Adult↗
PubMed1985

Cytotoxicity of corroded and non-corroded dental silver amalgams.

The cytotoxicity of one conventional and four non-gamma 2-amalgams was studied in a cell culture system, using the Millipore filter method. Before testing set amalgam specimens were kept in distilled water or in artificial saliva at pH 4, 5, or 7 for up to 28 wk to produce a corrosion layer on the test surface. Non-corroded set amalgam specimens was also tested. None of the noncorroded, set amalgams showed any sign of surface accumulation of cytotoxic products whereas the corroded amalgams showed varying degrees of cytotoxicity. Generally, the non-gamma 2-amalgams gave a more pronounced cytotoxic effect than the conventional amalgam. When the corrosion procedure was carried out at pH 7, the various non-gamma 2-amalgams showed different degrees of cytotoxicity. It appears that the difference in cytotoxic effect between the non-gamma 2-amalgams and the conventional amalgam as well as the differences among the various non-gamma 2-amalgams could be related to variation in the retention of corrosion products deposited on the amalgam surface.

Animals↗