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Biomedical subjects

G Hartmann

Publications and source records attributed to G Hartmann.

258 records · Page 15Linked to original sources
PubMedDate not supplied

[Delayed effects of neurotensin microinjections into the substantia nigra on conditioned motor reactions of rats with lesions to serotoninergic neurons].

Behavioral effects of neurotensin microinjections into the brain substantia nigra of rats with neurotoxic (5,7-dihydroxytryptamine) lesions of serotoninergic neurons in the dorsal raphe nucleus were studied. It was shown that neurotensin facilitated extinction of conditioned and intertrial reactions to negative (unreinforced) stimuli, but did not change the actualization of positive (with water reward) conditioned signals. Neurotensin-induced effects persisted in subsequent experiments without injections of the peptide. Neurotensin injections reduced the negative emotional states of lesioned animals in the arena during testing conditioned preference. It was concluded that the behavioral effects of neurotensin can be explained by the formation in the lesioned animals of the situational emotional state facilitating adaptive brain functions.

5,7-Dihydroxytryptamine↗
PubMedDate not supplied

[Effects of neurotensin on active and passive avoidance performance in rats with lesions of serotoninergic neurons].

After a lesion of serotoninergic neurons performed by administration of 5.7-dihydroxytriptamine into the dorsal raphe nucleus, effects of neurotensin microinjections into the substantia nigra on rat behavior were investigated. Serotoninergic lesions resulted in enhanced fear of rats manifested as an increase in the number of intersignal avoidance reactions and intensification of escape reactions. Neurotensin microinjections into the substantia nigra diminished the neurotoxin action thus increasing the adaptive character of defensive behavior of rats with deficit of functions of serotonin neurons.

Animals↗
PubMedDate not supplied

[Animal behavioral reactions, adrenocortical activity and brain energy metabolism under the action of propylnorantifein].

Behavioral reactions induced in white rats by propylnorantifein were studied by the tests of an open field, passive avoidance and self-stimulation from the medial bundle of the fore brain and Raffe suture. Biochemical analysis was done on the content of corticosteroids in blood plasma and that of glycogen and creatine phosphate in brain tissue. Propylantifein in a dose of 5 mg/kg was shown to decrease the self-stimulation, to change the emotional memory in response to pain stimulation, to increase the concentration of corticosteroids in blood plasma. During 3 hr after the drug administration brain tissue demonstrated the decreased glycogen content and particular, drastically reduced the drug action. It is suggested that propylantifein may activate the adenylcyclase system in brain tissue.

Adrenal Cortex↗