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Biomedical subjects

G Hart

Publications and source records attributed to G Hart.

At least 199 records · Page 11Linked to original sources
PubMed1979

Weight and skeletal maturation - a study of radiological and chronological age in an anorexia nervosa population.

The carpal bones of 18 anorexia nervosa patients were radiographed and the X-ray age assessed by 2 different standard methods. The study demonstrates that skeletal development in anorexia nervosa patients is delayed such that there is no association between radiological assessment of age and chronological age. It is strongly suggested that bony development actually ceases when body weight falls sufficiently to stop menstruation. There was a highly significant (P = 0.001) linear relationship between radiological age and the sum of the age of onset of the illness plus any period(s) of re-feeding. Weight gain seems to re-kindle the bone maturing mechanisms: the role of weight thresholds and associated hormone activity being discussed. The findings of this study strongly support the existing evidence that the anorexia nervosa patient is biologically and psychologically immature.

Adolescent↗
PubMed1978

Schizophrenia and albinism.

A female albino with squamous cell carcinoma and schizophrenia is reported. The association of schizophrenia and albinism is exceptionally rare; the observation that schizophrenia is characterised by hypermelanosis is questioned.

Adult↗
PubMed1977

Suppression of basal insulin secretion by adrenalin in normal man and in patients with insulinomas.

Basal insulin secretion has been thought to be via a different mechanism from stimulated insulin secretion, partly because it is not similarly suppressed by adrenalin. However, adrenalin normally causes hyperglycaemia, but if it is infused while the plasma glucose is kept constant there is marked suppression of insulin secretion. Sympathetic stimulation modulates basal insulin secretion, and alpha adrenergic blockade impaired the suppression of insulin secretion in response to hypoglycaemia. Four of five benign insulinomas had marked suppression of insulin secretion by adrenalin, but one malignant and one benign insulionoma had little suppression. Both had a raised proportion of their basal plasma insulin as proinsulin, and the impaired suppression of secretion by adrenalin probably signified an undifferentiated tumour.

Adenoma, Islet Cell↗
PubMed1977

Quantitative aspects of phenyl substituted alcohol and ether bacteriostatic interaction with Escherichia coli B/5.

It is well established that compounds of the class phenylalkane alcohols and ethers exert their antimicrobial action on the bacterial envelope--probably on the membrane. However, the overall stoichiometry, the number of molecules bound vs those merely added per cell, and the kinds of equilibria involved (site binding vs equipartitioning) are not clear. This work examines antimicrobial action on E. coli B/5 with eight such compounds. Directly determined binding data, plate counting viabilities, radiorespirometry, and microcalorimetry of glucose utilization were evaluated. The compounds mostly bind by simply equipartitioning, up to some threshold level, short of kill. That level depends sharply on the number of alkane carbons in the phenyl alkane derivative, but not on the precise structure. Past the threshold, bacteriostatic action is sudden and complete, probably reflecting cooperative behaviour in the cell envelope. The amount of bound compound at the threshold level is only about 0.5 to 3% of the weight of the bacterial envelope hydrocarbon, when bacteriostasis occurs. There is an unexpectedly small dependence on cell concentration. The principal governors on where the monooxygen phenylalkanes kill cells seems to be merely their concentration or chemical potential, the number of aliphatic carbons, and the binding mechanism. Because of the cell concentration independence, the cells act as if they constituted a second phase, relative to the solution. Results from the microcalorimetric method for assay of bacteriostasis correlate well with those from plate counting or viability assays.

Calorimetry↗
PubMed1976

Epidemiologic treatment of syphilis.

Epidemiologic treatment refers to antibiotics administered when a diagnosis is considered likely on clinical, laboratory, or epidemiologic grounds, but before the results of confirmatory laboratory tests are known. This treatment is justified on the grounds that the potenial benefits of treating the patient outweigh the potential harm of not treating. This potential harm may affect the individual or the community. Individual sequelae are most significnat when congenital syphilis is allowed to develop due to delays in treating the pregnant woman or newborn child. Community sequelae occur when an infected patient disseminates disease during the interval between initial presentation and final diagnosis. Unless qualified by time limitation and the behavioral and disease characteristics of a given population, exposure to syphilis is a poor criterion for epidemiologic treatment. The risk of infection of certain groups (defined by epidemiologic, clinical, or serologic criteria) should be determined empirically so that epidemiologic treatment is only provided to groups in which this risk has been estimated.

Counseling↗
PubMed1975

Venereal disease in a war environment: incidence and management.

The improved control over most infectious disease does not extend to venereal infections, and these now provide the major medical problem encountered in wartime. This factor should be recognized when staff and facilities are being provided for wartime medical services. Unique problems of management of both physical and psychological illness may result from promiscuity in a foreign land during war, and specialist venereologists are as necessary as surgeons and physicians.

Australia↗