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Biomedical subjects

G Hardy

Publications and source records attributed to G Hardy.

87 records · Page 5Linked to original sources
PubMed1980

Communication between cancer patients and physicians.

A total of 185 practicing physicians in middle Tennessee responded to a questionnaire regarding their communication patterns with cancer patients. This represented 61% of a total of 320 area physicians to whom questionnaires were mailed. Nearly 98% of responding physicians always or usually inform patients that they have cancer. No difference in communication was noted as a function of specialty or age. A number of terms are used at different times during the course of a patient's illness.

Adult↗
PubMed1977

Correlation between leucocyte-migration inhibition by breast-cancer antigens, mammographic findings, and other breast-cancer risk factors.

A double-blind study of 62 normal women was carried out to determine if there was any correlation between the mean score of six weekly leucocyte-migration-inhibition tests (L.M.T.) against breast-cancer antigen, xeromammographic findings, and the presence of other epidemiological risk factors for the development of breast cancer. 36 women had abnormal mammograms, and 11 of these 26 (30.5%) had a mean L.M.T. score greater than or equal to 10%. 26 women had normal mammograms, and only 1 of these (3.8%) had a mean value greater than or equal to 10%. This difference was significant (p less than 0.02). A family history of breast cancer and/or previous surgery for cystic and proliferative disease also correlated significantly with L.M.T. score (p less than 0.05); the combined presence of epidemiological risk factors and an abnormal mammogram correlated most strongly with L.M.T. score (p less than 0.01). Although the results may indicate an "immunological risk factor" towards the development of breast cancer, the biological relevance of this observation remains to be proven.

Adult↗
PubMed1977

Typhoid outbreak in Kingston, Ont: experience with high-dose oral ampicillin.

Twenty-four children contracted typhoid fever at a summer camp near Kingston, Ont. Six were treated with chloramphenicol alone and 15 with high doses of ampicillin (300 mg/kg-d) by mouth. Ampicillin in this dosage was well tolerated except in three children in whom severe urticarial rashes developed and two who had significant diarrhea. However, high-dose oral ampicillin therapy had no advantage over that with lower doses or over chloramphenicol as judged by the rate of defervescence after the start of treatment, the rate of clinical relapse and the frequency of excretion of Salmonella typhi during convalescence.

Adolescent↗
PubMed1977

Antibody to hepatitis B surface antigen in laboratory diagnostic sera.

Thirty-four commercial blood-grouping sera were tested for the presence of HBsAg and anti-HBs by radioimmunoassay technic. One sample (2.9% of the total) was positive for HBsAg, a marked reduction from previous reports; however, 11 sera (32.4%) were found to contain anti-HBs, a previously unreported finding. There is still some dispute as to the risk of infection from samples containing anti-HBs, which the authors hope will be resolved when tests for anti-HBc are readily available. In the meantime, the high antibody rate reflects a high rate of exposure to HBsAg of donors of commercial antisera, and laboratory personnel should be reminded of the possible risk of this less obvious source of infection.

Antibodies, Viral↗
PubMedDate not supplied

[Leukotrienes and 12-HETE: key mediators of angiotensin II-mediated vascular effects.Rol in hypertension].

Arachidonic acid metabolism-derived products are key mediators of angiotensin II-mediated vascular effects. The modulatory effect of cyclooxygenase derived products--in particular thromboxane A2 and prostaglandin H2--in angiotensin II-mediated vascular effects is well established. In contrast, few studies have assessed the involvement of lipoxygenase-derived products in the vascular effects of angiotensin II. Cysteinyl leukotrienes (5-lipoxygenase-derived products) and 12-hydroxyeicosatetraenoic acids (12-HETE) (12-lipoxygenase-derived products) are potent proinflammatory and vasomotor mediators. Their biosynthesis is increased in various models of hypertension. In addition, compelling evidence has suggested that they might contribute to the vasoconstrictor, hypertrophic and mitogenic effects of angiotensin II. The demonstration of their contribution to angiotensin II-mediated vascular effects may explain, at least in part, the vascular inflammatory complications associated with hypertension.

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid↗