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Biomedical subjects

G Hahn

Publications and source records attributed to G Hahn.

At least 109 records · Page 6Linked to original sources

[Results from the Central Laboratory for Streptococci Research in Kiel from 1965 to 1977 - a survey (author's transl)].

At the Central Laboratory for Streptococci Research at the Institute for Hygiene of the Federal Dairy Research Centre in Kiel a data bank has been established which comprises as well bibliographical data (until now more than 8000 titles out of the international literature concerning streptococci) as laboratory data of all strains which have been identified since 1965. For this present publication as a survey the total material covering 34,935 strains was analyzed and interpreted. Besides a short introduction describing the general examination procedure for streptococci and the encoding of results for the data bank the material is condensed in different tables considering the incidence of pathogenic species occuring mainly in man and animals. In addition findings of enterococci and lactic streptococci are presented. 41.8% of the strains examined were isolated from human specimens, 46.7% from cattle and the remaining ones from pigs, horses, dogs, laboratory animals and others. Only 2.0% of all cultures could not be identified as one of the known species. Remarkable observations are - the high incidence of group B-Streptococci in man - the unexpected frequency of typical "human" streptococci as those of group F and G and also Sc. milleri and Sc. MG in different animals - the possible interrelation of group L- and P-streptococci in pigs and cattle - the overlap of Sc. faecalis and Sc. faecium in man and animals showing no typical distribution as it is postulated in the literature - the high percentage of unidentifiable streptococci from pigs and laboratory animals as an eventual indication for some new species. In consecuting papers some problems emerging from the presented material and own experiments will be discussed as - interrelation of group B-Streptococci in man and cattle - incidence and importance of enterococci in humans, animals and foodstuffs and - classification of species not to identify by serological grouping.

Animals↗

Mandibular reconstruction.

The stainless steel 316 mesh tray with cancellous bone offers a method of mandibular reconstruction which theoretically is appealing from the viewpoint of basic osseous healing. The results in fity-two patients at twenty different institutions indicates encouraging results. Further evaluation of this method is recommended.

Adolescent↗

Lymphocyte activation by streptococcal antigens in psoriasis.

Cell-mediated immune responses in 28 hospitalized patients with psoriasis and in 36 healthy controls were studied using the two-step leukocyte migration agarose test. Specific cell-mediated immunity to A-streptococcal cell wall and cell membrane antigens occurred significantly more often in patients with psoriasis than in the control group. A statistically significant correlation between psoriasis-associated antigens of the HLA-B locus and cellular immune reactivity to A-streptococcal antigens or clinical course was not found. When patients with guttate psoriasis were compared separately with the control group, leukocyte migration inhibition induced by cell-free supernatants of A-streptococcal antigen-exposed mononuclear cell cultures was found to be more frequent than in other forms of psoriasis.

Adolescent↗

Identification of streptococcal groups A,B,C, and G by slide co-agglutination of antibody-sensitized protein A-containing staphylococci.

A total of 98.7% of streptococci, groups A,B,C, and G, isolated from various sources was correctly identified by the co-agglutination technique. The active components in this technique are protein A-containing staphylococci coated with antibodies specific for group A,B,C, and G streptococci. A suspension of streptococci belonging to one of these four groups co-agglutinates with the antibody-sensitized staphylococci specific for this group. The technique is extremely rapid and simple and requires no special equipment. It should therefore be a valuable alternative to other techniques used in the grouping of streptococci and is shown here to be as reliable as the Lancefield technique.

Agglutination Tests↗

[Comparative studies of dental plawue in students with and without dental caries. I. Enzymatic determination of the capacity to synthesize lactic acid in an aerobic medium].

In cultures of dental plaque taken from healthy dental surfaces of children susceptible to caries and children free from caries, the lactic acid content was determined. The cultures had an initial germ count of between 10(3) and 10(4) organisms per ml. After the cultures had been kept in artifical saliva for 7 hours under aerobic conditions, the samples of caries-susceptible children showed a considerably higher acid content than those of caries-free children. In comparative tests carried out in plaque samples simultaneously taken from the same dentitions, the micro-organisms of the samples taken from carious dental surfaces produced more lactic acid under the above mentioned conditions than those of the plaque samples taken from healthy dental surfaces.

Adolescent↗

Homograft and prosthetic aortic valve replacement: a comparative study.

Homograft aortic valve replacement was done in 103 patients and prosthetic aortic valve replacement in 106 between January 1962 and December 1973. Patients who received homograft and prosthetic valves were compared with respect to age, sex, preoperative functional impairment, infection, dyspnea, angina, hemodynamics, chest X-ray, electrocardiogram, associated operations, early and late mortality, and valve failure. Combined total mortality was 28% (12% operative, 8% first postoperative year, 8% late). Ten percent of valve required replacement. One year after operation, 70% of survivors were asymptomatic, 27% were improved, and 3% were unchanged or between homograft and prosthetic valve replacement. Valve-related failure and infections were more common after homograft aortic valve replacement. Emboli, hemorrhage, and hemolysis were commoner after prosthetic valve replacement. Fungal infections occurred in five homograft patients but in no patient with a prosthetic aortic valve. Severe properative symptoms or recent endocarditis was associated with greater mortality and valve failure in both the homograft and the prosthetic series. Increased mortality and failure was also seen in patients with either preoperative aortic regurgitation with high left ventricular end-diastolic pressure and low cardiac index, or aortic stenosis with cardiomegaly or roentgenographic evidence of congestive heart failure. Therefore, in two series of patients at equal risk, mortality and valve failure were similar for homograft and prosthetic aortic valve replacement.

Adolescent↗