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Biomedical subjects

G Habermann

Publications and source records attributed to G Habermann.

At least 19 recordsLinked to original sources

Background pathology of the common marmoset (Callithrix jacchus) in toxicological studies.

Two hundred common marmosets (Callithrix jacchus) from control groups (100 males, 100 females) of toxicological studies were examined histopathologically to evaluate the spectrum of spontaneous lesions in this species. Frequent findings were extramedullary hematopoiesis affecting adrenal glands, liver, kidney and spleen, cystic Brunner's glands in the duodenum, acute or subacute inflammation in the large intestine and gall bladder, renal mineralization and pigmentation, hepatic Ito-cell vacuolation, microgranuloma and glycogen storage, pituitary cysts, C-cell hyperplasia and lymphocytic foci of the thyroid gland, luteal hyperplasia of the ovary and inflammatory cell foci in various organs.

Acute Disease↗

Spontaneous epithelial plaques in the uterus of a non-pregnant cynomolgus monkey (Macaca fascicularis).

Two epithelial plaques were observed in the uterus of a 4 years 8 month old non-pregnant cynomolgus monkey. Normally, epithelial plaques occur near the implantation site of primates during early pregnancy but can also be induced by various procedures. Both plaques consisted of clusters and nest of cells with large nuclei and a faintly basophilic cytoplasm. Marked cellular pleomorphism was seen, including cells with giant nuclei and binucleated cells. Further histological features were vacuolation, mitosis and PAS-positive granules in several cells and polymorphonuclear infiltration in the periphery of the plaque. This is the second description of a spontaneous epithelial plaque in a primate and the first in a cynomolgus monkey.

Animals↗

Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis).

Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a smooth surface, that were located superficially along the interventricular septum, on the surface of the left ventricle or the apex of the heart. Microscopically, cysts were lined by a flattened epithelium and filled with keratin. Occasionally the epithelium was multi-layered or replaced by a rim of foreign body-type multinucleated giant cells. All animals with squamous cysts came from Mauritius, while those with squamous plaques came from Mauritius, China and Vietnam. As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development.

Animals↗

Cardiovascular and renal effects of systemic hypoxia in chronically instrumented conscious WKY and SHR rats.

The effects of systemic hypoxia upon cardiovascular and renal function in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) are controversial. We examined the effects of systemic normobaric hypoxia (12.5% O2 in N2 for 4 hours) on arterial blood gases (pO2, pCO2, pH), mean arterial pressure (MAP), heart rate (HR), effective renal blood flow (ERBF), glomerular filtration rate (GFR), urine flow (UMV) and renal sodium excretion (U Na V) in conscious unilaterally nephrectomized WKY (n = 12) and SHR (n = 14) chronically instrumented with an arterial, venous and ureter cannula. In WKY hypoxia caused a reduction in arterial pO2 and pCO2 but no change in MAP and HR. In SHR hypoxia induced similar reductions in arterial blood gases, a small decrease in MAP and no change in HR. In both strains hypoxia caused significant increases in ERBF, GFR and U Na V, but insignificant changes in UMV. The hypoxia-induced natriuresis developed 90-120 min after starting the hypoxia. These data indicate that a 4-hour lasting hypoxia has profound effects on sodium excretion in conscious WKY as well as SHR. Systemic hypoxia did not cause significant changes in arterial blood pressure in both rat strains.

Animals↗

[The emperor Nero as an example of the actor and singer in ancient Rome (author's transl)].

The question of what importance the human voice had as a means of expression in the Roman Empire and how orators, actors and singers trained and developed their voices can be seen in the example of the Emperor Nero (37--68 AD). The historians of late antiquity (in particular, Sueton and Tacitus) reported a deeper insight into Nero's complex personality. As a result, a number of details are known about his training as an artist as these relate to his appearance in public as an actor and singer. These findings can also be regarded as characteristic for the epoch of the time.

History, Ancient↗

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Anesthesiology↗

[On the classification of pathological timbres of the voice by hearing (author's transl)].

This is a form to diagnose as well healthy as pathological voices by hearing; it is meant to be practically experienced and criticized. It could by applied by laryngologists in future times who examine the voice of young people who intend to start the training for a job which mainly causes them to use their voice. You will find some groups of adjectives: two of them in juxtaposition and others which are in some close relation to one another. Thus we have got a set of instruments to fix the main audible differences of the voice and its changes, e.g. during some medical treatment. The complete structured list of adjectives concerning possible characteristic features of the voice is meant to help the laryngologist to classify those vocal impressions which seem typical to him.

Hoarseness↗

[Singer and actor under medical attention of the laryngologist].

Singers and actors offer special problems to the laryngologist as far as their personality is concerned as the individual intensity of their vocal usage. A successful therapeutical approach requires that the doctor is able to involve himself into the physical and psychic conditions of an artistic usage of the voice; he also should be as well open to singing as to music in general. Knowledge in pathophysiology of larynx and voice, experiences in phoniatry and psychological interests will enable the larngologist to solve such medical problems which occur when working on diseases of the voice of singers and actors. Based on these few remarks, the report deals with the following short chapters: doctor and singer, the most frequent causes of vocal disorders, the "dry throat' of the singer, coughing out of custom, vocal nodules, the prevention of damages of the voice, the singer's voice under endocrine influences, possible damages of the voice in connection with operations and - the actor with an ill voice.

Art↗

[The voice as a mirror of personality (author's transl)].

The philosopher and astrologer Scotus, who was famous for his translations from Greek and Arabic into Latin wrote a handbook of physiognomy for Emperor Friedrich II about 1228 A.D. In this volume based particularly on Arabic sources is a chapter on the voice. It contains numerous details that suposedly enable recognition of certain personality traits by voice characteristics. In the present such concepts are familiar, but that it was of practical relevance 750 years ago may justify closer inspection of Scotus and his work.

England↗