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Biomedical subjects

G H Vos

Publications and source records attributed to G H Vos.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Hemagglutination inhibition studies for the evaluation of blood group antigens in ethanol soluble substances (ESS) obtained from human, baboon and vervet monkey red blood cells.

Soluble blood group substances, isolated from the red blood cells of humans, baboons, and vervet monkeys by ethanol extraction, possessed serologically active specificities for the following antigens: A, B, H, Lea, LebL, P, P19 Pk and I. Human red blood cells lacking any of these specificities by the direct hemagglutination test also lacked the related antigens in their soluble extract. The only exception was in "Bombay" Oh cells, from which soluble H substance could be readily isolated. Soluble substances obtained from baboon and vervet monkey red blood cells, which lack the human variety of A, B, and H antigens on their red blood cells, inhibited both human and lectin anti-H reagents. The detection of "hidden" H activity in Oh cells will pose some important questions regarding membrane characteristics and the role of immune surveilance.

ABO Blood-Group System↗
PubMedDate not supplied

Hemagglutination inhibition studies of water soluble blood group substances recovered from the erythrocytes of classical Bombay Oh subjects.

Using ethanol and acetone fractionation to isolate soluble blood group substances from red blood cells, 'Bombay' Oh bloods were found to contain variable amounts of concealed H substance. The IgG variety of anti-H in 'Bombay' bloods has a greater affinity for these substances than the IgM variety of anti-H. Group O parents of 'Bombay' Oh subjects were found to have normal levels of H substance, indicating that individuals heterozygous for a recessive suppressor gene 'x' synthesize it normally. In the 'Bombay' family studied, Lewis determinants were abnormally expressed in two members. Lewis activity was detected in the soluble extracts of their red blood cells but not by the direct agglutination test. Further tests using known Le(a-b-) types are necessary to determine whether these findings are linked to the 'Bombay' Oh phenomenon.

ABO Blood-Group System↗