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Biomedical subjects

G H Findlay

Publications and source records attributed to G H Findlay.

At least 37 records · Page 2Linked to original sources
PubMed1983

Intractable skin disorders treated with the aromatic retinoid etretinate (Tigason). Two and a half years' experience in the Transvaal.

A trial of etretinate (Tigason) for keratinizing disorders of the skin yielded prolonged improvements beyond any results hitherto obtained. The disorders included psoriasis of severe degree, keratosis obturans, ichthyosis vulgaris, follicular ichthyosis, porokeratosis of Nékam, disseminated superficial actinic porokeratosis. Darier's disease, palmoplantar keratoderma, Oudtshoorn disease, lamellar ichthyosis, 'badpak' ichthyosis, epidermolytic hyperkeratosis, the 'half-baby' syndrome, exfoliative dermatitis, hair dystrophy and selected precancerous conditions. A method of management which worked well under local conditions is outlined.

Adolescent↗
PubMed1983

Cutaneous flavobacteriosis--polymorphous skin granulomas from Flavobacterium capsulatum. A case report.

A case of multiple eruptive skin granulomas caused by Flavobacterium capsulatum is described. The organism was resistant or poorly sensitive to all antibiotics except carbenicillin. Cure was brought about by using maximal doses of this drug. The source of the infection could not be proved, but it dated from an orthopaedic procedure to the elbow which was followed by a chronic cellulitis at the operation site. Since this is an organism known to occur in stored water, it was presumed that the flavobacterium was introduced into the wound from bottles of boiled and cooled water used in the operating theatre.

Bacterial Infections↗
PubMed1981

South African tick-bite fever (1931-1981).

An historical survey is given of the personalities and events connected with the discovery and investigation of tick-bite fever in South Africa over the past half-century.

Animals↗
PubMed1981

Disabling errors of skin keratinization. Ichthyosiform erythrodermas and the 'half-baby syndrome' treated with an aromatic retinoid.

The congenital ichthyosiform erythrodermas have become readily treatable with an aromatic retinoid. Satisfactory initial results over the first few months of treatment were achieved when the new preparation was given to Transvaal patients known to have these disorders and hitherto treated in vain. The pharmacology of the drug and therapeutic experiences in 6 cases are described.

Adult↗
PubMed1981

Non-diabetic necrobiosis lipoidica. Hitherto unrecognized papulonecrotic, nodulo-ulcerative and familial forms of the disease.

Necrobiosis lipoidica of the legs, in which deep ulcers resembling erythema induratum, gummas or a variety of other chronic progressive ulcerating skin diseases occur, is described. In 2 cases the lesions were precipitated by a crush injury elsewhere in the same leg, but not at the site of the ultimate lesions. In 2 further pairs of siblings the same problem arose as a familial complaint without trauma. These cases were distinguished by severe necrosis in the absence of diabetes.

Adult↗
PubMed1980

Chronic hydroquinone poisoning of the skin from skin-lightening cosmetics. A South African epidemic of ochronosis of the face in dark-skinned individuals.

Attention is drawn to the widespread use of bleaching preparations by Black women. These products often contain hydroquinone. They act efficiently as bleaching agents, but chronic oversaturation of the skin with hydroquinone eventually produces ochronosis. This complication has reached epidemic proportions in the Transvaal. Although the assay of hydroquinone in cosmetic products has not yet been standardized, we present some provisional results. The clinical, social and industrial aspects are also significant.

Black or African American↗
PubMed1979

Spore ultrastructure in Sporothrix schenckii.

Pathogenic strains of Sporothrix schenkii may show triangular spores, whose angular shape is maintained by a tie-beam effect in the inner cell wall structure. This difference in wall structure lies adjacent to a folded and possibly more active part of the spore cytoplasm. The supposed generation of asci in old cultures was simulated by the death of hyphae which are reinvaded by intrahyphal growth with intrahyphal spore production, while true asci were not seen.

Cell Membrane↗
PubMed1979

Actinic chickenpox. Light-distributed varicella eruption.

When areas of the skin which are normally covered become sunburnt just before chickenpox eruption, there occurs a marked intensification of the rash on the freshly burnt parts. This phenomenon is not widely known. Its history, published reports and our original observations on this 'actinic' chickenpox are presented, with comment on its pathogenesis.

Adult↗
PubMed1979

Black grain mycetoma: the ultrastructure of Madurella mycetomi.

Madurella mycetomi, the fungus pathogen of black grain mycetoma, shows an elaborate development of mesosomes as its most striking ultrastructural feature. These occur in addition to mitochondria and endoplasmic reticulum. Condensations of hyphal cytoplasm and recurring intrahyphal growth of new hyphal cells are features of the pigment-producing and pathogenic phases of the organism. The abundant pigment which histochemically resembled melanin was not traceable to any ultrastructural granule, nor was it built from a tyrosine precursor. The ultrastructural changes occurring in collagen through a sclerotizing action by the fungus are briefly noted.

Catechols↗
PubMed1978

Erythrokeratolysis hiemalis--keratolytic winter erythema or 'Oudtshoorn Skin'. A new epidermal genodermatosis with its histological features.

A new autosomal, dominantly inherited epidermal disorder is described in which a spreading dissection of the stratum corneum with redness of the palms and soles occurs as a result of a centrifugal necrobiosis of the Malpighian layer below it. Iis is seen characteristically in winter. In extensive cases the limbs and trunk are affected with gyrate scaling erythemas.

Child, Preschool↗