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Biomedical subjects

G H Conner

Publications and source records attributed to G H Conner.

At least 37 records · Page 2Linked to original sources
PubMed1976

Local immune responses in the bovine fetus vaccinated in utero with Escherichia coli antigen.

Using specific immunofluorescent examinations, the local immune responses were studied in 14 calves prenatally vaccinated (10 to 50 days before birth) with Escherichia coli (O26:K60:NM) antigen or sterile saline solution. All calves were colostrum-deprived, were given oral doses of homologous organisms (killed or live), and were necropsied either at birth or within 12 days after birth. Immunofluorescent plasma cells were not seen in duodenum, jejunum, jejunal lymph nodes, ileum, ileal lymph node, or spleen of control calves prenatally vaccinated with sterile saline solution. All of these tissues, except ileal lymph node, from calves vaccinated in utero with E coli showed fluorescence. Jejunum, jejunal lymph node, and ileum had the greatest number of immunofluorescent plasma cells. There were more immunoglobulin G2-than immunoglobulin M-producing cells. The cells producing specific antibodies against E coli (1 calf studied) comprised approximately 33% of the total number of immunofluorescent cells.

Animals↗
PubMed1972

Prenatal immunization by the oral route: stimulation of Brucella antibody in fetal lambs.

No simple means exists for immunizing infants and large animals in utero. The feasibility of stimulating immune response by the oral route was investigated by using the fetal lamb as experimental model and Brucella as prototype antigen. Antigenic stimulation was assessed by serum agglutinin levels. Primary and secondary responses were elicited in fetal lambs by Brucella antigen introduced into the amniotic fluid 10 to 50 days prenatally. One lamb born 75 days after primary exposure in utero mounted a secondary response to antigen at 2 days of age. The evidence of immunization by the oral route suggests that local intestinal immunity also might be acquired in fetal life by this route.

Administration, Oral↗
PubMed1972

Tracheostomy.

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Humans↗