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Biomedical subjects

G H Bush

Publications and source records attributed to G H Bush.

At least 37 records · Page 2Linked to original sources

A study of glycopyrrolate and atropine in the suppression of the oculocardiac reflex during strabismus surgery in children.

Glycopyrrolate 5 and 7.5 micrograms kg-1 and atropine 10 and 15 micrograms kg-1 were studied in 80 paediatric patients to assess more fully the dose of glycopyrrolate required for adequate prevention of the oculocardiac reflex. A dose-related improvement in protection from this reflex was seen with both drugs, but neither drug prevented reductions in heart rate in every patient. A nodal rhythm was the most common arrhythmia observed with both drugs. In the doses used, no adverse effects were noted and no further anticholinergic treatment was required during muscle traction. Higher doses may be associated with an increase in side-effects with more pronounced dryness of the mouth and tachycardia and, with atropine, a greater likelihood of the production of the "central anticholinergic syndrome".

Arrhythmias, Cardiac↗

Plasma potassium after halothane--suxamethonium induction in children.

The changes in plasma potassium following inhalation induction of anaesthesia with halothane followed by suxamethonium were studied in 48 normal children aged 1 to 10 years. Highly significant increases were found in both age groups studied (5 years and under, and 6 to 10 years). The mean percentage increase in plasma potassium and the proportion of children in whom an increase of 0.4 mmol/litre or greater was found, were both greater than in an earlier study on children after thiopentone induction and suxamethonium.

Anesthesia, Inhalation↗

Congenital diaphragmatic hernia in the older child.

Five children aged between 9 months and 7 years were admitted to hospital each with an unsuspected congenital diaphragmatic hernia. In 4 the diagnosis was pneumonia with a secondary pleural effusion or lung abscess. Initial investigations were unhelpful to the admitting physician; two of the children had had a previous chest x-ray which was normal. For 3 children the correct diagnosis was only made at necropsy. It is suggested that the possibility of a congenital diaphragmatic hernia be considered in any patient who has an indefinable diaphragm and cystic lesion on his chest x-ray film. Barium studies with the patient in Trendelenburg's position are of value in excluding the presence of bowel in the chest.

Child↗

Ventilatory support for children with whooping cough. Experience with children admitted to a paediatric intensive care unit.

Twenty-four patients with pertussis admitted to a paediatric Intensive Care Unit over a period of 42 months are reviewed. It is concluded that pertussis affects the young baby most severely, the majority of the children admitted were under the age of 3 months. Many required long term intubation and pulmonary supportive therapy and the percentage of those admitted to the Intensive Care Unit who have needed mechanical ventilation has steadily increased over the period reviewed from 25 to 71%. The youngest infant died from overwhelming respiratory infection. The other 23 patients recovered but three children developed neurological complications and their recovery is still being assessed. The importance of maintenance of the immunisation programme is stressed in view of the evidence of the severity of the disease in the very young infant.

Anti-Bacterial Agents↗

Tracheal compression as a cause of respiratory symptoms after repair of oesophageal atresia.

A case of tracheal compression in an infant after repair of a tracheo-oesophageal fistula and oesophageal atresia is reported. Tracheopexy completely relieved the symptoms of apnoeic attacks, cyanosis, and convulsions. We suggest that tracheal compression in infants and children with repaired oesophgeal atresia can not only cause life-threatening attacks but also be responsible for recurrent chest infections. All infants and children with signs and symptoms of tracheal compression as shown by the presence of a barking type of cough, recurrent chest infections, or persistent mild respiratory symptoms should be referred for thorough investigation of the tracheobronchial tree.

Endoscopy↗

The management of the retained tracheostomy tube.

A tracheostomy tube that has to be retained despite attempts to remove it, must de defined as a retained tube. The previous literature is reviewed. The consequences of establishing a tracheostomy are described and, based on these considerations, recommendations are made for a regime to allow decannulation to be performed.

Humans↗