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Biomedical subjects

G H Bresnick

Publications and source records attributed to G H Bresnick.

11 recordsLinked to original sources
PubMed1992

Characterization of the electroretinographic scotopic B-wave amplitude in diabetic and normal subjects.

The intensity-response function of the scotopic b-wave of the electroretinogram may be a useful device for monitoring patients with retinal disease. Three models were evaluated that describe this function in 152 patients with diabetic retinopathy of varying severity and in 40 nondiabetic comparison subjects. The models considered were the Naka-Rushton equation fit to all 21 data points collected, the Naka-Rushton equation fit to the data points below the "second limb" of the function, and a log-linear fit only to data at the nine lowest intensities. In addition, the b-wave amplitude at each intensity tested was evaluated individually. Model parameters and amplitude measurements were compared with respect to (1) their ability to distinguish diabetic from nondiabetic subjects determined from the area under the receiver operating characteristic curve and (2) their correlation with retinopathic severity, graded in a standard fashion in fundus photographs. When all the parameters of each model were used in combination, there were no significant differences among the models with either evaluation criterion. Furthermore, b-wave amplitudes at midrange intensities (near -2.2 log cd-sec/m2) did approximately as well as any model.

Adolescent↗
PubMed1979

Retinal wrinkling and macular heterotopia in diabetic retinopathy.

Retinal wrinkling of the posterior pole was studied in 40 eyes from 31 patients with diabetic retinopathy. Vitreoretinal traction was thought to produce the wrinkling in 32 of the eyes, in 13 of which macular heterotopia also developed, presumably from the same tractional forces. Epiretinal membrane formation was the apparent causal factor producing retinal wrinkling in six eyes and postphotocoagulation chorioretinal scarring in two eyes, in none of which macular heterotopia developed. Retinal wrinkling alone was associated with only mild or no visual acuity loss. Macular heterotopia was associated with more severe loss of visual acuity and with other visual symptoms. Displacement of retinal vessels was an important clue to the diagnosis of macular heterotopia.

Adult↗
PubMed1979

A method for recording vitreoretinal relationships.

A method for recording vitreoretinal relationships is described. The system includes designations for the extent and height of posterior hyaloid detachment and for sites of abnormal vitreoretinal adhesions. The method may be used for preoperative evaluation of eyes prior to vitrectomy surgery or for the follow-up of patients with vitreoretinal disease.

Eye Diseases↗
PubMed1979

Retinal branch vessel occlusion in acute intermittent porphyria.

Three patients with acute intermittent porphyria were noted to have retinal branch vessel occlusion. Branch "vein" occlusion, segmental optic atrophy, and soft exudate were the most common ocular manifestation. Two patients had labile elevated hypertension. When patients present with retinal branch vessel occlusion and a constellation of bizarre symptoms that might include hypertension, abdominal pain, acute psychotic behavior and/or cutaneous photosensitivity, the diagnosis of acute intermittent porphyria should be considered.

Abdomen↗
PubMed1978

Postvitrectomy keratopathy.

Twenty-six of 75 eyes undergoing pars plana vitrectomy developed significant corneal complications requiring treatment. Slow or nonhealing epithelial abrasions, recurrent corneal erosion, and microcystoid and striate keratitis were among the most frequent problems. Significant predisposing factors included diabetes, surgical trauma such as epithelial debridement and prolonged operative time, aphakia, and postoperative glaucoma or hyphema. Corneal complications may be minimized with careful preoperative and operative precautions.

Adult↗
PubMed1977

Clinicopathologic correlations in diabetic retinopathy. II. Clinical and histologic appearances of retinal capillary microaneurysms.

One eye of a 21-year-old patient with proliferative diabetic retinopathy was available for clinicopathologic correlation. The fluorescent spots in a fluorescein angiogram were correlated with the changes in color fundus photographs and with the corresponding histologic findings in a trypsin digest preparation of the retina. A round, regular fluorescent spot was the most reliable diagnostic indicator of retinal capillary microaneurysms, although some microaneurysms appeared as irregular fluorescent spots, tiny fluorescent spots, or dark silhouettes with or without fluorescent halos. Very large fluorescent spots correlated with very large irregular pouches that may represent intraretinal neovascularization. Fluorescein angiography was considerably more sensitive than color fundus photography for the detection of retinal capillary microaneurysms.

Adult↗
PubMed1976

Choroidal neovascular membrane in Best's vitelliform macular dystrophy.

The right eye of a 9-year-old white boy with Best's vitelliform macular dystrophy had an intact egg-yolk lesion and a retinal pigment epithelial defect superiorly, suggesting an early pseudohypopyon stage. The disruptive phase of the left eye showed subretinal hemorrhages, a "signet ring," and a subretinal neovascular membrane.

Child↗
PubMed1975

Retinal ischemia in diabetic retinopathy.

Eight patients with proliferative diabetic retinopathy developed extensive retinal arteriolar and capillary obstruction. Ophthalmoscopy showed many white, thread-like retinal arterioles associated with capillary and venous dilatation. Widespread retinal arteriolar and capillary nonperfusion was demonstrated by fluorescein angiography. Ischemic maculopathy resulted in severe loss of visual acuity in some eyes. The severe degree of retinal ischemia was accompanied by optic disc pallor and neovascularization and a high incidence of rubeosis iridis with neovascular glaucoma. Patients with this variety of diabetic retinopathy have a poor prognosis of retaining useful vision.

Adolescent↗
PubMedDate not supplied

Pars plana vitrectomy. Vitrectomy in diabetic retinopathy.

In spite of the rather high rate of complications, it is clear that in selected cases of proliferative diabetic retinopathy with massive long-standing vitreous hemorrhage, significant improvement can be accomplished by pars plana vitrectomy. However, the number of eyes recovering 20/40 vision or better remains small (7% in our series at 9 to 15 months postvitrectomy), and consideration needs to be given to means to improve these figures. Whether vitrectomy at an earlier stage of the retinopathy can accomplish this is the subject of an upcoming cooperative study under the sponsorship of the National Eye Institute.

Cataract Extraction↗