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Biomedical subjects

G Gwinup

Publications and source records attributed to G Gwinup.

71 records · Page 4Linked to original sources
PubMed1967

The hypothalamic-pituitary-adrenocortical system. Clinical evaluation by pharmacologic techniques.

The hypothalamic-pituitary-adrenocortical system is a complex negative feed-back control mechanism. Under non-stress conditions it functions to maintain a circadian rhythm of adrenal steroid production which is secondary to a circadian fluctuation in the sensitivity to suppression of acth by hydrocortisone. Any stressful stimulus causes an augmentation of steroid production which is due in part to a decrease in sensitivity of acth to suppression. Aldosterone production is not primarily controlled by acth. The increased understanding of this system and of its pathologic alterations has led to the development of a number of pharmacologic techniques which have proved most valuable in evaluating its integrity. Hypothalamic-pituitary function can be assessed by the response to the administration of dexamethasone, methopyrapone, bacterial pyrogen and vasopressin. Adrenal cortical function can be assessed by the response to acth, dexamethasone and spironolactone.

Adrenal Glands↗
PubMedDate not supplied

A case of group B streptococcal pyomyositis.

The group B streptococcus is an opportunistic pathogen that causes a variety of serious infections including bacteremias, puerperal sepsis, and neonatal meningitis. Group B streptococcal infections of muscle are rare. We report here an unusual case of group B streptococcal pyomyositis. Pyomyositis arises predominantly from infections caused by Staphylococcus aureus and, occasionally, Streptococcus pyogenes. Because of the rarity of pyomyositis in temperate climates, the common lack of localizing signs or symptoms, and the frequently negative blood cultures, considerable delay often precedes the diagnosis of pyomyositis; in fact, the infection has been initially misdiagnosed as muscle hematoma, cellulitis, thrombophlebitis, osteomyelitis, or neoplasm. Diagnosis may be greatly aided by radiologic techniques that can demonstrate the sites of muscle enlargement and the presence of fluid collections. The response to antibiotics is usually rapid, but resolution of the infection may require aspiration of deeply situated muscle abscesses. This report describes a diabetic patient with an unusual presentation of pyomyositis that mimicked an acute abdomen.

Abdomen, Acute↗
PubMedDate not supplied

Evidence for TSH autoregulation of thyroid carcinoma.

Presumptive evidence for TSH dependency of thyroid hormone secretion from metastatic thyroid cancer is presented. In the patient described, the metastatic tumor was the only source of thyroid hormone production which was adequate enough to maintain the patient euthyroid. Tumor secretion of thyroid hormone appeared to regulate the TSH drive so that euthyroidism was maintained in the face of increasing tumor mass.

Adenocarcinoma↗
PubMedDate not supplied

Weight loss without dietary restriction: efficacy of different forms of aerobic exercise.

Since obese patients with orthopaedic disabilities are often advised to undertake swimming as a part of a weight loss program, the effect of swimming on body weight was systematically studied. Minimally to moderately obese, otherwise healthy young women seeking to lose weight through a program of exercise without dietary restrictions were randomly assigned to one of three groups in which only the type of daily exercise was different. The three types of exercise were brisk walking, riding a stationary cycle, and swimming laps in a pool. All women slowly but progressively increased the time spent in daily exercise to 60 minutes. After 6 months or slightly longer, the women assigned to walking lost 10% of initial weight, the women who cycled lost 12%, but the women who swam lost no weight. The thickness of the subcutaneous panniculus over the middle of the extensor surface of the upper arm was measured using a Lang skin-fold caliper (Graham Field Co, New York, NY) and showed equivalent substantial reductions in the walkers and cyclists, but no change in the swimmers. The results of this study show that both walking and cycling are effective methods of reducing body fat, but that swimming is not.

Adult↗
PubMedDate not supplied

Relationship between serum estradiol concentration and IGF-I, IGF-II and IGF-binding proteins in patients with premature ovarian failure on short-term estradiol therapy.

OBJECTIVE: Insulin-like growth factors (IGFs) exert stimulatory effects on follicular growth and development, and early embryogenesis. In view of this, we studied the effect of short-term estradiol treatment, as used in preparing the uterus for embryo implantation, on the serum concentrations of IGFs and their binding proteins (IGFBP) in patients with premature ovarian failure (POF). PATIENTS AND METHODS: Twenty-four patients with POF, enrolled in an assisted reproduction program, were treated with increasing doses of estradiol up to 8 mg daily for 6 weeks. Blood was sampled for measurement of serum estradiol, IGF-I, IGF-II, and IGFBP 1, 2 and 3 at various times during estradiol treatment. RESULTS: There was no significant correlation between serum estradiol concentrations and the serum concentrations of IGF-I and IGF-II. As expected, IGF-I and IGF-II concentrations in serum correlated positively with the serum concentration of IGFBP-3, the major IGF-binding protein in serum. CONCLUSION: The results of this study suggest that estradiol therapy as used to prepare the uterus for implantation has no significant effect on serum IGF-I and IGF-II concentrations, and therefore probably does not influence, via an IGF-mediated mechanism, the success of implantation and early embryonic development.

Adult↗