Biomedical subjects

G Gum

Publications and source records attributed to G Gum.

4 recordsLinked to original sources

PubMed1990

Superior sagittal sinus thrombosis in a patient with protein S deficiency.

A 30-year-old man presented with sagittal sinus thrombosis. He had a history of multiple thrombotic events since adolescence, and his father had had a similar history. Laboratory studies revealed the complete absence of free protein S in his plasma. Protein S deficiency, an autosomal dominant disorder, is an identifiable cause of cerebral thrombosis. The literature and our experience with this case suggest that long-term anticoagulant therapy may prevent thrombotic episodes in patients with this disorder.

Adult↗

PubMed1988

Quantitative autofluorescence in the ovine and canine ocular fundus in ceroid-lipofuscinosis (Batten's disease).

Yellow-green autofluorescence was quantified in the fundi of sheep and dogs with ceroid-lipofuscinosis, using a modified photographic slit-lamp microscope with motorized scanning probe, a photomultiplier system and a digital radiometer. In age-matched controls, no fluorescence was detected. The technique should prove useful as a clinical aid in the early differential diagnosis of this disease and in the basic study of aging.

Aging↗

PubMed1982

Decrease in canine corneal endothelial cell density and increase in corneal thickness as functions of age.

Fifty-nine normal dogs, ranging in age from 6 weeks to 132 months were examined with contact specular microscopy to determine the relationship of age to corneal endothelial cell density, morphology, and corneal thickness. Canine corneal endothelial cells appear quite similar to those of other species studied, including man. The hexagonally shaped canine endothelial cells tend to enlarge with age, with the population in young animals averaging around 2500 cells/mm2 and the number of cells in older dogs being frequently below 2100 cells/mm2. A significant increase in corneal thickness was observed with age. Healthy canine corneal endothelial cells appear to maintain a functional monolayer by enlargement and migration and represent a reasonable model for future endothelial cell study.

Age Factors↗

PubMed1979

Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.

Four carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, ethoxzolamide, and methazolamide) cause ocular hypotony in normotensive and glaucomatous Beagles. Four dosages of acetazolamide and methazolamide and three dosages of dichlorphenamide and ethoxzolamide were evaluated. The extent of ocular hypotony after these carbonic anhydrase inhibitors was usually greater in glaucomatous Beagles than it was in normotensive Beagles.

Acetazolamide↗