[Effects on lipid metabolism of inhibitors of cholesterol synthesis].
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Biomedical subjects
Publications and source records attributed to G Guarini.
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Other researches WE HAVE carried out show how it is possible to correct the high level of neutral fats in subjects with high trygliceridemia, with the administration of KI. We wished to ascertain whether the capacity of KI to reduce trygliceridemia when this is increased should be correlated to a possible change induced by this salt on PHA. Our researches has been carried out on 11 subjects who received a daily dose of 28 mg/Kg of b.w. of KI for a period of 10 days. The result we have obtained indicates that the administration of KI does not cause any significant change of PHA both after load and after prolonged treatment with KI.
Changes of hemocoagulability and of plasmatic fibrinolysis have induced us to study PHA following the administration of the lipid load. We have studied the effects induced by the administration of a lipid load, constituted by 1/2 g of olive oil and by 1/2 g of butter dissolved in 200 ml of vaccine milk. PHA has been estimated in all our subjects under basal conditions and after 4 1/2 hours from the lipid load. The statistical analysis of the results we have obtained shows a significant PHA reduction following the lipid load. Concluding, our results indicates that the lipid load very frequently causes a reduction of PHA which is due to a consumption of heparin. This consumption is more probably due to the activation of lipoprotein-lipase by heparin.
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