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Biomedical subjects

G Grasso

Publications and source records attributed to G Grasso.

At least 91 records · Page 5Linked to original sources
PubMed1985

The physiological interferon response. V. Antiviral activity present in rat lymph is neutralized by anti-mouse interferon-gamma antibodies.

By neutralization tests using anti-rat and mouse interferon (IFN) antibodies, we tested whether the antiviral activity present in abdominal lymph but absent in plasma of healthy rats, could be ascribed to IFN. Antimouse IFN-gamma antibodies neutralized the inhibitor completely while anti-rat IFN-alpha/beta antibodies did not. We conclude that rat lymph contains traces of IFN-gamma and that the antiviral activity is not due to low-density lipoproteins, immunoglobulins, or to cell-produced viral inhibitors. This finding extends previous observations on rabbit lymph and further supports the existence of a physiological low-level interferon response.

Animals↗
PubMed1984

The physiological interferon response. II. Interferon is present in lymph but not in plasma of healthy rabbits.

If interferon is produced by the gut-associated lymphoid tissue of healthy rabbits under normal conditions and is not all bound in situ, it may spill over and be detectable in lymph. We therefore measured antiviral activity in lymph and plasma simultaneously. We found that antiviral activity was consistently measurable in abdominal and thoracic lymph but not in plasma or in the lymph collected from the hind leg duct. The antiviral activity was neither due to lipoproteins, nor immunoglobulins, nor to cell-produced viral inhibitors other than interferons. Extensive characterization of the antiviral activity indicated that the inhibitor is either rabbit interferon gamma or an acid-labile interferon alpha or a mixture; appropriate antisera will be necessary to resolve this uncertainty. The results support the view of the existence of a physiological interferon response.

Abdomen↗
PubMed1983

Vesiculation of human erythrocytes incubated in protein-free media.

Erythrocytes incubated in different protein-free media release vesicle other than glycopeptides. The presence of glucose blocks the release of glycopeptides almost completely but not the vesiculation phenomenon. In vitro ageing of erythrocytes provokes a marked discocyte-spheroechinocyte transformation and a redistribution of membrane components.

Erythrocyte Aging↗
PubMed1983

Ontogenesis of autonomic receptors in detrusor muscle and bladder sphincter of human fetus.

An investigation was made of the distribution and the ontogenesis of various types of receptors in the bladder detrusor muscles and sphincter isolated from human fetuses at different stages of pregnancy. Cholinergic receptors appear very early in the fetal urinary bladder since contractile responses to bethanechol, competitively blocked by atropine, are observed in detrusor muscle preparations at three months and in the sphincter at four months. Later on, the density of cholinergic receptors increases in the detrusor muscle whereas there is a progressive reduction in the sphincter.

Female↗
PubMed1983

The physiological interferon response. I. Cells attached to intrauterine devices release interferon in vitro.

Cells attached to intrauterine devices (IUDs) release interferon (IFN) in the medium during incubation in vitro. Most of the IFN is released during the first hour suggesting that the cells had been previously induced and were probably already producing IFN in vivo. Characterization of the IFN indicates that most of it is of gamma-type with a trace of alpha. Production of IFN in the uterine fluid would represent a first example of the physiological IFN response and may serve to modulate some of the mechanisms preventing implantation of blastocyst. The actual presence of IFN in the uterine secretion remains to be demonstrated.

Culture Techniques↗
PubMed1983

p-p'DDT in perinatal samples: report on maternal and neonatal measurements.

Organochlorine pesticides and their degradation products can affect humans in several ways and are detected in human tissue, including placental tissue and umbilical cord blood. We report the results of preliminary research conducted to determine the levels of p-p'DDT in maternal and umbilical cord blood during labor and to estimate the possible consequences of this product for calcium metabolism. The results confirm that p-p'DDT is transferred to the fetus through the placenta and indicate the existence of a complex fetal-maternal p-p'DDT distribution mechanism.

Calcium↗
PubMed1980

[Angioimmunoblastic lymphadenopathy. Treatment of 2 cases].

Following a review of the literature, 2 cases of angioimmunoblastic lymphadenopathy with dysproteinaemia are reported. Anatomo-pathological examination of the lymphonodes shows widespread change in the structure with vascular and lympho-immunoblastic proliferation and deposit of amorphous eosinophil substance. The most significant clinical and morphological aspects are reported and these are related to the therapeutic response. The effectiveness of cortisone therapy is shown by comparison of laboratory examination data at admittance and after three months.

Adrenal Cortex Hormones↗
PubMed1980

[The vascular network and the perivascular spaces of the pars distalis of the hypophysis in developing chick embryos].

A quantitative analysis of the modifications undergone by the vascular networks and the perivascular spaces in the rudiment of the adenohypophysis has been carried out in normally developing chick embryos from the 7th incubation day to hatching. The present results point to the existence, during the developmental period mentioned, of a relationship between the extent of the capillary bed and, respectively, of the perivascular spaces, the gradual increment of the former being paralleled by a decrease of the latter. The rate of these events appears to be higher between the 14th and the 16th incubation days, namely when the vessels begin to acquire some of the morphological features typical of sinusoids, their thin walls getting gradually into closer contact with the secretory epithelial cells.

Animals↗
PubMed1980

[A case of primary echinococcosis of the breast].

A case of hydatid cyst of the breast is reported. Stress is laid on its extreme rarity, the aspecificity of its symptomatology and the importance of considering this type of pathology in the differential diagnosis of cystic conditions of the breast.

Adult↗
PubMed1980

Ampicillin-associated colitis. Case report.

A case of ampicillin-associated colitis is described. The authors stress the importance of emergency colonoscopy for the correct diagnosis and treatment of severe diarrhea and hemorrhage occurring during treatment with antibiotics.

Adult↗
PubMed1980

Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal.

Chronic atrophic gastritis and a sessile polyp were diagnosed during gastroscopy of a patient with splenomegaly and portal hypertension. The polyp was removed endoscopically. Histologically, it proved to be an endocrine tumour, which was identified as gastrinoma by immunohistochemistry. Then, hypergastrinemia was found and gastrectomy was performed to ensure complete removal of the tumour. The surgical specimen showed G cell hyperplasia of the antro-pyloric mucosa and severe atrophic gastritis with scattered argyrophil micronodules in the corpus-fundus region. 3 years after this treatment the patient is well.

Adenoma, Islet Cell↗
PubMed1979

[Correlations between the processes of cell differentiation and development of blood vessels in the (chick embryo) adenohypohhysis].

Utilizing semi-thin and, respectively, thick sections after indian ink injections, we have analyzed morphohistogenesis and vessel development in the adenohypophysis of chick embryos from the 4th to the 19th incubation day. Our preliminary results indicate that a close correlation exists between cellular differentiation and vasculogenesis. Vessels begin to enter the gland only at the 6th day when the first endocellular granules become detectable, and, from the 10th day, they markedly increase in number and size, gradually acquiring a peculiar sinusoidal arrangement around cellular groups, as cell differentiation further progresses.

Animals↗