Biomedical subjects

G Grant

Publications and source records attributed to G Grant.

At least 235 records · Page 13Linked to original sources

PubMed1979

Polaroid Corporation.

Explore the source record for details and available documents.

Cost Control↗

PubMed1979

Transganglionic transport of horseradish peroxidase in primary sensory neurons.

The cut end of the sciatic nerve of adult rats was exposed to horseradish peroxidase (HRP). The rats were allowed to survive for 12 h--5 days. 12--18 h postoperatively small dorsal root ganglion cells more heavily labeled than large ones. After 48--72 h more large cells were intensely labeled. From 18 h onwards large amounts of HRP labeling was observed ipsilaterally in the superficial laminae of the dorsal horn, from 48 h also in deeper laminae and in the gracile nucleus. The heavy labeling clearly indicates the potential of the present approach for mapping purposes. The findings also indicate that short postoperative survivals can be used for rather selective marking of small cells and fibers.

Animals↗

PubMed1978

Epidemiology and clinical significance of cervical erosion in women attending a family planning clinic.

Women attending a family planning clinic were studied to determine the relation between cervical erosion and clinical and social characteristics. The appearance of the cervix was recorded without knowledge of the women's symptoms. The prevalence of erosion increased with parity but, when the effects of other factors were controlled, decreased in women aged 35 and over. Erosion was significantly more common in women taking the "pill" and less common in women using barrier methods of contraception than in others. There was considerable variation between doctors in the reporting of erosion. No association was found between erosion and postcoital bleeding, dyspareunia, backache, or dysuria. There was a significant but modest association between erosion and vaginal discharge and a suggestion that erosion may sometimes be associated with nocturia and frequency of micturition. Vaginal flora was similar in women with and without erosion. Cervical erosion should not be regarded as pathological in asymptomatic women, nor should it be assumed necessarily to be the cause of symptoms in women with genitourinary complaints.

Adolescent↗

PubMed1978

Comparison of three treatments for fractures of the diaphysis of the femur.

Sixty-eight patients with fractured femurs were studied who, in terms of personal characteristics, associated injuries and type of fracture, could have been treated by intramedullary nailing or traction followed by the application of either a spica cast or fracture brace. Twenty-eight patients actually underwent intramedullary nailing, while 18 were treated with a spica cast and 22 with a fracture brace. Multiple outcome factors were studied and, based upon every comparison, intramedullary nailing was found superior. Among those patients treated by non-operative techniques, fracture bracing permitted earlier independent ambulation and increased the probability of normal knee motion at the conclusion of treatment.

Absenteeism↗

PubMed1975

Columnar distribution of U-fibres from the postcruciate cerebral projection area of the cat's group I muscle afferents.

Needle stitch lesions were made in the maximal point of the cerebral projection area of the low threshold muscle afferents near the postcruciate dimple of the cat's posterior sigmoid gyrus. The lesions did not exceed 500 mum in diameter and were restricted to the cortical grey matter. Degenerating nerve fibres and terminals were investigated with Fink-Heimer technique in four cats (survival times: 26, 48 and 96 hours). The cytoarchitectonic areas of the sensori-motor cortex were determined in cresyl violet and van Gieson sections. All lesions were made in area 3a. Degenerating U-fibres originating from the lesion travelled in the white matter to the cortex of area 4 gamma, 3b and 2. They reentered the cortex and branched in layer III. Terminal degeneration was found in layer I. The degeneration was distributed to distinct columns with a diameter of about 1mm. Such columns were observed laterally and medially in area 4 gamma, in area 3b near the caudal end of the coronal sulcus, in area 2 near the lateral ansate sulcus and in the forelimb region of SII. The distribution of the cortico-cortical connections from the cerebral projection area of the forelimb group I muscle afferents was discussed in relation to the known cerebral projections of group I muscle afferents, low threshold joint afferents, pacinian afferents and low threshold skin afferents.

Animals↗

PubMed1975

Transganglionic degeneration in trigeminal primary sensory neurons.

In 16 kittens either the frontal or the inferior alveolar nerve was transected and in 17 adult rats either the supraorbital, the infraorbital or the mental nerve was divided. The postoperative survival periods were kept at 3-28 days for the kittens and 15-26 days for the rats. Sections from the caudal brain stem and the upper part of the cervical cord were impregnated according to the Fink-Heimer method, procedure II. In the kittens degeneration was found after the 8th postoperative day ipsilaterally in both the spinal and main sensory trigeminal nuclei and the spinal trigeminal tract. In the rats degeneration was found in all cases in the same ipsilateral structures as in the kittens. The amount of degeneration was relatively great in the rats, whereas it was very modest in the kittens. A somatotopical pattern was found for the degeneration both within the spinal and the main sensory nuclei. It was in agreement with what has been found in earlier studies, where other techniques have been used. By a comparison with the results of a previous study on the trigeminal nerve in the rat, where partial lesions of the ganglia had been made, it was found that the degeneration in the present study did not cover the whole area receiving primary trigeminal afferents. Possible explanations for this are discussed.

Age Factors↗

PubMed1975