Neural network computations on RNA sequences are used to demonstrate that data compression is possible in these sequences. The result implies that a certain discrimination should be achievable between structured vs random regions. The technique is illustrated by computing the compressibility of short RNA sequences such as tRNA. The method should be valuable in measuring the information content of DNA, including noncoding DNA, which has been shown to display certain properties resembling natural language attributes.

Base Sequence↗

PubMedDate not supplied

Computer assisted transcutaneous oxygen monitoring.

A computerized system for acquisition of data from a transcutaneous PO2 (PtcO2) monitor is presented. A North Star Computer, Inc., "Horizon" microcomputer was used in this system. The PtcO2 monitor was a Radiometer TCM-1 equipped with an external printer interface. The system had a custom interface module to accept binary-coded decimal data from the PtcO2 monitor. In addition, a 16-channel, 12-bit A/D module, a real-time clock module with interrupt capability, and a high-resolution graphics module were incorporated.

Computers↗

PubMedDate not supplied

Neuroendocrine carcinoma of the stomach with extensive somatostatin immunoreactivity.

Upper gastrointestinal tract neuroendocrine tumors producing predominantly somatostatin have thus far been described only in the duodenum; their characteristic features include the frequent presence of psammoma bodies (psammomatous somatostinomas), and the association with von Recklinghausen's neurofibromatosis. Gastric neuroendocrine tumors, on the other hand, tend to display immunoreactivity to serotonin but may include small subpopulations producing gastrin, motilin, pancreatic polypeptide, and somatostatin. In this report we describe a neuroendocrine carcinoma of the stomach with rapidly fatal outcome, displaying neurosecretory granules by electron microscopy and immunoreactivity to pan-neuroendocrine markers, ie, chromogranin and neuron-specific enolase. The only neuroendocrine regulatory peptide detected in the tumor was somatostatin, identified by immunohistochemistry in the majority of neoplastic cells. In contrast with duodenal somatostinomas, there were no psammoma bodies and no demonstrable association with von Recklinghausen's neurofibromatosis. To our knowledge this appears to be the first report of a malignant neuroendocrine tumor with diffuse somatostatin immunoreactivity.

Aged↗

PubMedDate not supplied

The vocabulary of experience. Interview by Jane E. Blumenthal.

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District of Columbia↗