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Biomedical subjects

G Grabner

Publications and source records attributed to G Grabner.

At least 163 records · Page 9Linked to original sources
PubMed1976

[A new antihypertensive imidazoline derivative (St 600, Fluoronidine): I. Haemodynamic investigations at rest and during exercise (author's transl)].

Treatment of 12 hypertensive patients with a new imidazoline derivative, St 600 (1.5 to 12.0 mg daily over at least 7 days) resulted in a significant lowering of the blood pressure, mostly to normal values, parallelled by a reduced heart heart rate. A significant decrease in arterial resistance was observed at rest and during exercise in 6 of the patients, whereas a slight increase or no change was recorded in the remaining 6 patients. The changes in resistance in the pulmonary circulation were analogous to those in the systematic circulation for the 2 groups, respectively. The latter half of the patients displayed a decrease in stroke volume, cardiac index and oxygen consumption. No negative inotropic effect was observed.

Adult↗
PubMed1976

[Multiple nodular densities on chest X-ray in liver cirrhosis--a diagnostic problem? (author's transl)].

A case report is given of a 49 year old white male patient, who had suffered for several years from liver cirrhosis and who finally died from hepatoma. Although a hepatoma was suspected in this case it was not demonstrated intra vitam, though at autopsy it was found to have invaded the lower vena cava, continuing into the right atrium. Problems of early diagnosis of hepatoma are discussed in context with this case.

Carcinoma, Hepatocellular↗
PubMed1976

[Fat resorption: current concepts and micromophology].

Recent concepts in the physiology of intestinal fat absorption are reviewed and the intraluminal formation and the role of the mixed lipid micelle, the concept of the unstirred water layer and the role of the fatty acid binding protein in the intracellular transport of long chain fatty acids are particularly emphasized. It is pointed out that only little information is available on the exact mechanism of the synthesis of intestinal lipoproteins and their export from the intestinal epithelial cells. Finally, preliminary results are presented of an electron-microscopical investigation of the intestinal mucosa of rats at different intervals after intraduodenal injection of an emulsion of lipids.

Animals↗
PubMed1975

Secretin-induced bile secretion, bile acid output and blood supply to the liver in the dog.

Bile secretion and blood flow in the portal vein and the hepatic artery were determined in cholecystectomized anesthetized dogs before and during continuous infusion of varying doses of secretin. Secretin increases bile volume without alteration of bile acid output. Hepatic arterial flow was not altered by any dose. However, high doses of secretin increased portal venous blood flow significantly. It is concluded that secretin action on liver blood flow mirrors mainly superior mesenteric arterial vasodilation and seems to be a rather pharmacologic than a physiologic response. Bile secretion is not influenced by changes of hepatic blood flow in the physiologic range.

Animals↗
PubMed1975

Effect of portacaval shunt and arterialization of the liver on bile acid metabolism.

The effect on bile acid clearance of portacaval end-to-side shunt, with and without arterialization of the hepatic portal venous bed, was studied in dogs. Portacaval shunt reduced liver blood flow by 75%, and peripheral serum bile acid concentration rose from 3 to 239 muM. Arterialization maintained total liver blood flow within physiological range and serum bile acid concentration was only 19 muM. Since hepatic bile acid extraction was similar in both groups, bile acid clearance was determined largely by total liver blood flow. The results of this study indicate that hepatic clearance of substances originating from portal blood is impaired in portacaval shunt and can be restored by increasing the arterial blood supply to the liver.

Ammonia↗
PubMed1975

[Physiology of bile secretion].

Canalicular bile secreted by the hepatocyte consists of at least two fractions: one is initiated by active transport of bile acids, the other is due to active transport of inorganic ions. Bilirubin and other organic anions, organic cations, and neutral compounds are secreted into the canalicular bile as well as lecithin and cholesterol. Subsequently the biliary tree, the gallbladder, and the enterohepatic circulation of bile acids have an effect on bile formation. Choleresis induced by drugs may be due to a direct osmotic effect of the compound secreted in bile or to an increase of the bile acid independent fraction of bile flow. Cholestasis frequently is caused by inhibition of the bile acid independent fraction. Studies on micellar solubility of cholesterol have led to new concepts concerning formation of cholesterol gallstones and their dissolution with chenodeoxycholic-acid therapy.

Amiloride↗
PubMed1975

[Clinical and morphological features during the course of Whipple's disease(author's transl)].

Clinical and histological characteristics of Whipple's disease have been described extensively by various authors, but there are only few reports about repeated documentation of clinical and especially of micromorphological features during the course of the disease. We therefore report a case who was followed closely over a period of 3 years; small bowel biopsy was performed on 6 occasions during this time. Antibiotic therapy brought complete recovery from the disease and was followed by the disappearance of bacillary bodies in the lamina propria of intestinal mucosa. Despite this, many macrophages containing the typical PAS-positive material could still be demonstrated. The development of macrophages as well as etiologic aspects of the disease are discussed.

Adult↗