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Biomedical subjects

G Gola

Publications and source records attributed to G Gola.

At least 37 records · Page 2Linked to original sources
PubMed1979

17 beta-estradiol, 5 alpha-dihydrotestosterone, progesterone and cortisol receptors in normal and neoplastic human endometrium.

Using the value of 0.24 fmoles/microgram DNA as breaking point between high and low binding capacities, we quantified receptors for 17 beta-estradiol (ER), 5 alpha-dihydrotestosterone (DHTR), progesterone (PR) and cortisol (CR) in normal and neoplastic human uterine tissues. Concerning receptors occurrence, significant relationships were observed between ER and PR, ER and DHTR, and DHTR and PR. A direct correlation between the presence of ER and tumor grading was found: PR was less frequent in grade II and absent in grade III endometrial carcinoma, however this was not a significant correlation. In endometrial carcinoma at least 1 of the receptors was detected in 67-91% of the cases, 3 receptors (ER, DHTR, PR) in 56%, and all 4 receptors in 45%. The simultaneous detection of multiple receptors could play an important role in determining hormone response.

Aged↗
PubMed1978

The ocr gene function of bacterial viruses T3 and T7 prevents host-controlled modification.

On pre-infection of the host Escherichia coli B with u.v.-inactivated T3 or T7 phage able to express their early genes (like 0.3), B-specific modification of superinfecting, successfully multiplying viruses does not take place. The ocr gene function (gene 0.3) of T3 and T7 not only prevents host-specific DNA restriction but also modification, probably by inhibiting the same late step in the interaction between the restriction enzyme and DNA.

Coliphages↗
PubMed1977

Cytoplasmic receptors for 17 beta-estradiol, 5 alpha-dihydrotestosterone and progesterone in normal and abnormal human uterine tissues.

Determinations of specific cytoplasmic receptors for 17 beta-estradiol (E), 5 alpha-dihydrotestosterone (DHT) and progesterone (P) in normal and abnormal endometrium are reported. The standardization of methodology with particular emphasis on specificity trials is outlined. Receptors were present in all but one case, a moderately differentiated endometrial adenocarcinoma. Generally speaking, steroid and peptide hormone plasma content in patients with malignant conditions were at the lower limit values of normal, except for follicle-stimulating hormone which had values significantly higher than normal. The question of E competition with DHT in binding DHT-receptor and the therapeutic implications of P-receptor estimation are discussed.

Adult↗
PubMedDate not supplied

[Orocraniofacial changes in young subjects with cystic fibrosis].

Cystic Fibrosis is a lethal genetic disorder affecting the respiratory, gastro intestinal, exocrine end reproductive systems. From the orthodontic point of view, respiratory changes are of great interest. In fact, cephalometric tracings and cast analysis on 20 subjects with Cystic Fibrosis have revealed changes at the orofacial structures, strictly related to the respiratory dysfunctions. They can be summarized as: mesial shifting of the maxilla, dimensional increase of the mandibular body, ovoidal upper arch with a deeper palatal vault, tapering or trapezoidal lower arch. Even if causes can be hardly distinguished from effects, the role of the juvenile oral breathing in these cases seems to be any way undeniable with statistically significant results.

Cephalometry↗