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Biomedical subjects

G Goerz

Publications and source records attributed to G Goerz.

At least 235 records · Page 13Linked to original sources
PubMed1977

[Long time HCB exposition of rats: influence on the porphyrin excretion in the urine and on the cytochrome P-450 in the liver (author's transl)].

Adult female Wistar rats were fed with a diet containing 0.05% HCB. About the 55th day of the experiments an increase of porphyrin and its precursors (ALA and PBG) in the urine of the rats can be measured. In contrast the induction of the O-dealcylation reaction of 7-ethoxycoumarin could be already measured 2 days after starting with the HCB feeding. The inhibition of the enzymatic reaction by metyrapone, naphthoflavone, tetrahydrofurane or CO/O2 presents neither the typical pattern of the phenobarbital type nor the typical pattern of the benzpyrene type of cytochrome P-450. When the animals became porphyric (about the 55th day of the HCB exposure) no qualitative changes in the cytochrome P-450 pattern could be demonstrated. The relationship between the enzyme induction in the liver and the porphyria following the HCB application is still remaining unclear.

Animals↗
PubMed1977

[Treatment of photodermatoses with carotinoids (author's transl)].

39 patients were treated with carotinoids (beta-carotene alone or combined with canthaxanthine) with an oral dose of 50-150 mg/d, some of them for a period of several years. 23 of these were patients with porphyria (erythropoietic protoporphyria [EPP] 20, congenital erythropoietic porphyria 2, erythropoietic coproporphyria 1); 16 patients were suffering from various photodermatoses (solar urticaria 6, actinic reticuloid 5, UV-A intolerance 1, unclassified photodermatoses 4). Tolerance of the carotinoids was very good; no side effects were seen except for a yellow discoloration of the skin. In 19 of 20 EPP patients the result of the treatment was good, whereas no improvement was seen in the other kinds of porphyria. Of the 16 cases of photodermatoses not caused by porphyrinopathy, 6 responded to the therapy (solar urticaria 2, actinic reticuloid 2, UV-A intolerance 1, unclassified photodermatosis 1). Some cases showed great improvement as a result of the treatment.

Adolescent↗
PubMed1977

[Is cytarabine an effective drug against herpes zoster? (author's transl)].

Although herpes zoster is a viral infection with spontaneous healing, the skin eruption is painful and there may be serious complications. Cytarabine was administered to 91 patients with the disease. It was given by quick infusion or intravenously twice daily for five days. An open, uncontrolled study of 61 patients suggested that the drug was beneficial without serious side effects. But in a double-blind randomised study of 30 patients there was no significant effect on the course of the disease. The mean healing time for skin blisters in segmental uncomplicated zoster was 8.4 days with cytarabine and 6.5 days with a placebo.

Clinical Trials as Topic↗
PubMed1977

[Psoriasis: A general disease? Can psoriasis be explained biochemically?].

The biochemical problems of psoriasis are discussed, especially two modern hypothesis about the pathogenesis of this skin disease. 1. DHEA-deficiency leading to an increase of G-6-PDH inaugurated by Holzmann et al. 2. cAMP deficiency in psoriatic lesions as a cause of psoriasis hypothized by Voorhees and Duell. A synopsis of the physiology of the steroid hormone DHEA (synthesis, regulation, conjugation and excretion) is given. There are doubts that this hypothesis is correct. Recent findings have indicated, that there is no decrease of cAMP in the psoriatic lesion--in contrast there is an increase of this cyclic nucleotid. It means that this theory is also doubtfull. Treatment of an hypothetical decrease of cAMP by AMP is not possible, because this AMP will not penetrate in the cell and cannot be metabolized to cAMP.

Adolescent↗
PubMed1976

[Skin tests with phytohaemagglutinin (PHA). Correlation with other parameters of cell-mediated immunity (author's transl)].

100 healthy persons were investigated to find out whether there is a correlation between a lymphocyte stimulation (3H-thymidine incorporation in the lymphocyte transformation test) with phytohaemagglutinin, pokeweed mitogen and concanavalin A and the in vivo reactivity to intracutaneous phytohaemagglutinin application (measured as medium diameter of infiltrates). Further we searched for an influence of positive or negative reactivity to the specific antigens trichophytin, candidin and streptokinase-streptodornase. 1. There is a good qualitative correlation in normal persons between in vitro lymphocyte stimulation by phytohaemagglutinin, pokeweed mitogen and concanavalin A and the medium diameter of infiltrates after intracutaneous application of 2 mug phytohaemagglutinin. Using lower doses of phytohaemagglutinin no such correlation could be found. A quantitative correlation between the medium diameter of infiltrates and lymphocyte transformation by phytohaemagglutinin and pokeweed mitogen cannot be demonstrated. For concanavalin A there is a negative correlation significant at the 99% level. 2. In vivo reactivity to phytohaemagglutinin does not differ in persons with negative and positive reactions to the specific antigens. 3. Lymphocyte stimulation by phytohaemagglutinin, pokeweed mitogen and concanavalin A of persons with positive reactions to trichophytin, candidin and streptokinase-streptodornase is significantly greater than in those with negative reactivity. 4. The results indicate in vivo phytohaemagglutinin testing as a good screening method to judge cell-mediated immunocompetence. The general applicability for differentiation of immunodeficient and immunocompetent patients is to be further investigated.

Adolescent↗
PubMed1976

[Erythropoietic protoporphyria: porphyrin content of a gall-stone (author's transl)].

In the case of a 48 year old woman with characteristic signs of erythropoetic protoporphyria, a solitary gall-stone which had persisted over a period of 10 years was removed. Porphyrin-concentration of this gall-stone was found to be 22.6 mcg/g, which is almost twenty times the concentration of other cholestrol-stones. Besides protoporphyrin, porphyrins with a higher degree of carboxylation were discovered in four different samples by thin layer chromatography. It is postulated that the increased bile-concentration of protoporphyrin in the liver causes the cristallisation of cholestrol and the formation and growth of gall-stones. The biochemical finding of porphyrins with a higher degree of carboxylation indicates that the porphyrins of the gall-stone may not only come from hemolysed erythrocytes but possibly also from metabolites of disturbed hepatic porphyrin biosynthesis.

Cholelithiasis↗
PubMed1976

[Letter: Porphyria cutanea tarda: normalization of porphyrin-excretion following treatment with p-amino-benzoic acid (Potaba) (author's transl)].

Two patients with porphyria cutanea tarda were treated with p-amino-benzoic acid (Potaba) (3x4g/day). Normalization of porphyrin-excretion was observed after three respectively 45 days of treatment. Furthermore no influence of the excretion of porphyrin precursors (porphobilinogen or delta-amino-levulinic acid) were noticed. Also, no side effects of this treatment were found.

Adult↗
PubMed1976

[Accident in treatment of porphyria cutanea tarda by chloroquine (Resochin) (author's transl)].

About a 65-year old patient with the typical clinical and biochemical characteristics of porphyria cutanea tarda (Pct) is reported. After treatment with Resochin in an erroneously high dosage (1.250 mg instead of 125 mg) an acute crisis set in with a triple increase of porphyrin excretion, fever, tachycardia, hypertension and joint-discomfort. Despite the rise in excretion of total porphyrines in urine to approximately 18.00 mcg/l there was no change in the amount of the porphyrin precursors (ALA, PBG). The pattern of the porphyrin-metabolites (URO-, HEPTA,- HEXA-, PENTA-, COPRO-porphyrin)-expressed in rel.%-does not change during the excessive rise of porphyrin excretion. The duration Resochin-therapy could obviously not be shortened by an initial too high dosage of chloroquine. The mechanism of action of chloroquine in Pct is not clear. It is discussed that a change in the permeability of the liver mitochondria leads to a continuously increased excretion of porphyrin and to an exhaustion of the hepatic porphyrin pool.

Aminolevulinic Acid↗
PubMed1976

[Mycosis fungoides affecting the eye and internal organs (author's transl)].

In two patients with mycosis fungoides the following were found in the region of the eye: Infiltration of the eyelid (sometimes board-like), infiltrations and swellings of the connective tissue, orbital infiltrations (hard as a board) with secondary glaucoma, atrophy of the optic nerve, amaurosis, Descemet spots, cells in the aqueous humour, preretinal opacities of the vitreous body), intussusception of retinal vessels, grey infiltration of the retina.

Adult↗
PubMed1976

[Clinical and histological results of lyell-syndrome (author's transl)].

The Lyell-syndrome and the importance to ophthalmology is demonstrated. The nosological position - as staphylococcal disease (almost only in childhood) and as allergic extreme variant of bullous mucocutaneous disease is described. The differential diagnosis of similar (identical?) syndromes is discussed: Fuchs-syndrome, Baader-syndrome, Fiessinger-Rendu-syndrome. About 15 personal patients and 40 in the literature with LS with participation of the eyes is reported. The clinical results, development of the disease and the histological pictures of the cornea are made for the first time discussed. The therapy by lamellar or penetrating keratoplasty is reported.

Adult↗