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Biomedical subjects

G Goerz

Publications and source records attributed to G Goerz.

At least 181 records · Page 10Linked to original sources
PubMed1981

Urticaria in association with etiocholanolone fever.

A 17-year-old girl is reported with a history of recurrent febrile episodes during her menstrual bleeding accompanied by a generalised exanthem. Increased plasma levels of unbound etiocholanolone were noticed during the febrile attacks. Both the fever and the skin eruption could be suppressed by oral contraceptives.

Adolescent↗
PubMed1981

Dapsone in the treatment of lupus erythematosus.

Dapsone yielded excellent therapeutic results in certain forms of lupus erythematosus (LE), whereas discoid lesions and the maculo-papular rash of the systemic and disseminated chronic forms of discoid LE remained uninfluenced by the drug. On the basis of these observations, we suggest the following indications for dapsone treatment in LE: (1) Vasculitic urticaria. (2) Oral ulceration. (3) Non-scarring form of chronic LE. (4) Chloroquine intolerance.

Adult↗
PubMed1981

Syndrome of ichthyosis congenita, neurosensory deafness, oligophrenia, dental aplasia, brachydactyly, clinodactyly, accessory cervical ribs and carcinoma of the thyroid.

We report the case of a 15-year-old girl with a uneventful family history. Her skin condition was clinically, histologically and ultrastructurally compatible with the diagnosis of ichthyosis congenita. She suffered from neurosensory deafness and oligophrenia. Further findings included dental aplasia, brachydactyly, clinodactyly and accessory cervical ribs. At the age of 14, a thyroid carcinoma was diagnosed. Therapy with a retinoid derivative (Ro 10-9359) resulted in a marked improvement of the ichthyosis. We assume a genetic syndrome with autosomal-recessive inheritance.

Abnormalities, Multiple↗
PubMed1981

[Non allergic skin reactions of drugs (author's transl)].

Non allergic skin reactions are differentiated in the following way: overdose, idiosyncrasy, intolerance and side effects. An intoxication caused by an overdose of a drug may be initiated by an increased resorption through the skin (e. g. salicylic acid or the obsolete boric acid). An overdose of a drug often leads to coma and in many cases, if the patients are lying unattended (e. g. at home). ischemic skin reactions, such as blisters or necrosis occur at pressure areas. Intolerance is an undesirable reaction, produced by a normal therapeutic dose of the drug. Reactions of special interest are those imitating an anaphylactic reaction (type I), such as histamine liberation, complement activation or intolerance to analgetics, dyes or preserving agents. Idiosyncrasy summarizes reactions, which differs both qualitatively and quantitatively from the normal response to therapeutic dose of a drug. Additionaly these reactions are characterized by an underlying biochemical disturbance: drug-induced porphyric crisis in porphyria acuta intermittens, INH induced pellagra or drug-induced lupus erythematosus are discussed in this context in greater detail. Side effects of a drug is a misnomen, but this term cannot be done without. These undesired effects can be differentiated into obligatory effects as seen after cytostatic treatment in the form of alopecia; and possible reactions such as chloasmas after treatment with oral hormonal contraceptives. We assume that some of these side effects would belong to the category of idiosyncrasy or intolerance, if their pathogenesis were known.

Anaphylaxis↗
PubMed1981

[Granulomatous allergic reaction of the delayed type to surfen].

In the last five years, a distinct increase of allergic reactions to surfen, a constituent of various insulin preparations, was observed. The allergic reactions were tuberculoid granulomas of the delayed type (type IV of Gell and Coombs). Intracutaneous tests with surfen or surfen-containing insulin preparations confirmed the diagnosis. Dermal infiltrates and mild erythema developed 24 to 96 hours after the injection of insulin. In some patients a post-inflammatory pigmentation was noted. Histological examination of the lesions and the intracutaneous test sites revealed a granulomatous inflammation without signs of foreign body reaction. At present, the cause of the increased incidence of allergic reactions to surfen remains hypothetical.

Chemical Phenomena↗
PubMed1981

[Influence of theophylline on hexachlorobenzene induced porphyria (author's transl)].

Administration of 0.05% hexachlorobenzene (HCB) contained in the food to female (Wistar rats over a period of 60 days induced porphyria as measured by the increased urinary porphyrin excretion. One group of the rats was additionally treated with theophylline (150 mg/kg b.w./d). The concomitant theophylline application to rats with HCB induced porphyria increased their urinary excretion of porphyrin (p less than 0,1%) and its precursors (porphobilinogen and delta-aminolevulinic acid) in comparison to the HCB controls. The HCB induced increase of the hepatic cytochrome P-450 content was prevented whereas 7-ethoxycoumarine-deethylase activity was depressed concomitantly by theophylline. p-Nitro-anisole-demethylase activity was not influenced by this treatment. It is assumed that the delta-amino-levulinic acid synthase is induced by theophylline. The different behaviour of the porphyrin excretion and the cytochrome P-450 induction during this treatment leads to the conclusion that there is no direct or causal relationship between these two biochemical processes.

Animals↗
PubMed1980

[Serologic hepatitis B markers in porphyria cutanea tarda (author's transl)].

Using several seromarkers for hepatitis B virus the frequency of previous hepatitis B in patients with porphyria cutanea tarda (PCT) as a possible manifestation factor was determined. As chronic hepatitis is frequently associated with an increase of factor VIII-associated antigen, this was included in the investigation. Results make it likely that 28 out of 60 investigated patients (47%) have had hepatitis. In 30% an increase of factor VIII-associated antigen was found. It can be assumed that hepatitis B virus infection as a manifestation factor may be of considerable importance in porphyria cutanea tarda when genetic disposition (uroporphyrinogen-decarboxylase deficiency) is present.

Antigens↗
PubMed1980

The involvement of porphyrogenic steroids in the development of experimental porphyria.

Hexachlorobenzene alters the hepatic steroid metabolism, and it was suggested that a porphyria was induced by overproduction of 5 beta-H-steroids. Structurally similar chlorinated hydrocarbons (pentachlorobenzene, pentachlorophenol, 2,4,5-trichlorophenol) without porphyrogenic activity did not affect the steroid metabolism in rat liver.

3-Hydroxysteroid Dehydrogenases↗
PubMed1980

[Non-allergic drug exanthemas].

Drug reactions similar to allergic reactions according to the differentiation by Coombs and Gell--type I to type V--can be triggered by drugs without the interaction of antibodies and lymphocytes. The immediate hypersensitivity reaction (type I) is imitated in three ways: 1. Histamine release from mast cells or basophiles by drugs without regines (IgE, IgG4), 2. complement activation by a drug via the classic or alternative pathway without reaction with an antibody. 2. intolerance reaction, that means a chronic urticaria triggered by an inhibitor of the prostaglandin synthesis (Aspirin, other analgesics, food additives and dyes). In contrast to the above reactions, non-immune mechanisms mimicking type II to type V reactions are of inferior clinical importance.

Complement Activation↗