[Considerations and remarks on new list of occupational diseases in industry and agriculture].
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Biomedical subjects
Publications and source records attributed to G Giuliano.
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A hemodynamic research was carried out by the authors in ten patients affected with upper limb "vibration angiopathy", as well as in ten healthy control subjects. Digital artery flow and systolic, diastolic and mean pressures were measured, and vascular resistances and the so-called "systolic index" calculated, both in basal condition and following hand warming. In patients with "vibration angiopathy" fingers were examined, which on a previous arteriographic study showed the most and the least severe arterial lesions, respectively. No statistically significant differences were detected between the mean values of the hemodynamic indices obtained from the most and the least involved fingers, respectively, as well as between such values and the control subject ones. These results would suggest--even with due reservation on account of the relatively small number of cases and of their different features--that digital artery lesions, as shown by arteriography, have no definite hemodynamic significance. The lack of a statistically significant decrease of the digital artery mean pressure, compared to control subjects, supports the hypothesis that Raynaud's phenomenon in "vibration angiopathy" is not due to a transmural pressure fall. Finally, the lack of correlation between the severity of arterial lesions and Raynaud's phenomenon site suggests that the vasomotion impairment which causes the phenomenon is not related to such lesions.
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A longitudinal electromyographic study was carried out on fifteen shoe-industry workers (one man and fourteen women) affected with toxic polyneuropathy. The mean values of age, duration of exposure and lenght of the follow-up period were 23.2 years, 4.2 years and 12.2 months, respectively. Twelve subjects (80%) had a sensory-motor involvement of both upper and lower limbs; in the remainder, only the latter were affected. From a clinical standpoint, the polyneuropathy was classified as mild in seven subjects (46.6%), moderate in four (26.7%) and severe in four. On the basis of electromyographic criteria (maximal motor nerve conduction velocity; features of voluntary contraction tracings; existence of spontaneous activity recorded in different points of the same muscle), the polyneuropathy could be defined as mild in two patients (13.3%), moderate in three (20%) and severe in 10 (66.7%). In eight subjects (53.3%) the electromyographic abnormalities disappeared completely, through a gradual improvement in six and alternative phases of improvement and worsening in two. As for the remainder patients (7, viz. 46.6%), improvement and worsening in two. As for the remainder patients (7, viz. 46.6%), four showed a reduction of their electromyographic abnormalities, whereas no significant changes occurred in the last three. The obtained results are discussed and the following conclusions drawn: 1. the lower limbs are mostly affected, both clinically and electromyographically; 2. the clinical symptoms do not parallel the electromyographic findings; 3. the course of the disease appears to be independent of the initial electromyographic pattern; 4. recovery appears to occur in most instances within approximately eighteen months since the onset of symptoms, generally without significant residual deficit. Finally, the role of electromyography in the diagnosis and the follow-up study of the observed toxic polyneuropathy is underlined.
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The AA. have studied the behaviour of LP-X in fifty cases of viral hepatitis printing out a positivity in 32% of the examined cases, with a positivity of the Au-antigen in the 34% of cases. They have observed a more remarkable inclination to the cholostasis in children (40% of the cases of positivity of LP-X), concluding for a scarce specificity of such a "marker" of cholostasis.
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