[Influence of vitamin E and propylgallate on cancerogenesis with benzopyrene in mice].
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Biomedical subjects
Publications and source records attributed to G Giuliani.
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53%, and 29.8% respectively, of a sample of 500 adults living in Turin have been shown lacking of any antibody against A/Victoria/3/75 and B/Hong Kong/8/73 influenza strains; less than 20%, and 45.4% respectively, possessed antibodies at a protective level (greater than or equal to 1:40). Furthermore, the study of age distribution of immunity against A/New Jersey/76 has confirmed specific h.a.i. antibodies to be present, at a significant level, only from the sixth decade onwards.
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The authors evaluate the effectiveness of combination groups of antiedema pharmacological agents on experimental transient bilateral cerebral ischemia. The results show that dexamethasone and furosemide appear to be the most useful combination group. However, the improvement of post-ischemic vascular re-perfusion is not different when these antiedema agents are employed simultaneously or when they are administrated alone. The experimental model allows the authors to evaluate various modalities of the injection of the dye and drugs. Better filling of the cerebral hemisphere in which the antiedema agents were injected through the common carotid artery is always recorded. Therefore, the authors conclude that the best way to obtain homogeneous post-ischemic vascular re-perfusion is to inject half of drugs through the left common carotid artery and half through the right common carotid artery.
During the outbreak of rubella in Turin in 1977, 1,041 newborns, whose mother's pregnancy coincided with the epidemic, were studied for the elimination of rubella virus through inoculation in primary cultures of African green monkey kidney cells. Additional 10 embryos or fetuses of therapeutic abortion from women with rubella early in pregnancy were studied through cultivation of material of abortion and inoculation in monkey cells. Only one strain was isolated, from the placenta of an embryo whose mother suffered rubella in the 2nd month of pregnancy. The hypothesis is proposed of a particularly benignity, from a teratogenic point of view, of the virus involved in the outbreak.
The age-prevalence of antibodies directed against the hepatitis viruses A (anti-HAV) and B (anti-HBs and anti-HBc) has been studied in an open sample of population of Turin (Italy), made up by 680 persons. Is has been shown that all three types of antibodies are present at birth, thast they progressively decrease and than again raise, from 6-10 years of age, up to 70-75%, 35% and about 40% in adults, respectively for anti-HAV, anti-HBs and anti-HBc. A further peak over 97% after 40 years for anti-HAV likely means a past higher spreading of the virus. The conclusion is drawn that, for both hepatitis A and B, the percentage of positive and the time of appearance of active humoral immunity after the loss of maternal antibodies are typical medium level of hygienic conditions. The comparison of anti-HBs and anti-HBc behaviour has shown that the latter is more frequent and at least as persistent as the former, and that it should not therefore be obligatory considered ia a marker of viral replication.
The authors describe an experimental model of transient (15 min). unilateral, cerebral ischemia followed by 60 min of reperfusion in anesthetized rats. Zones of non perfusion are recorded and referred to as the "no-reflow phenomenon". The authors believe that vascular changes which interfere with postischemic reperfusion are due to ischemia-induced swelling of perivascular glia. The effects of the intracarotid injection of dexamethasone, furosemide and escina are evaluated in the attempt to show the importance of brain edema in ischemic cerebral damage.
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