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Biomedical subjects

G Giovannelli

Publications and source records attributed to G Giovannelli.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Pituitary TSH response to TRH: interrelationships with gonadal activity.

A TSH radioimmunoassay is described, which was used to investigate the behaviour of the TSH pituitary response (as measured by the secretory area) to TRH in groups of subjects of both sexes and different phases of gonadal activity. It is concluded that the TSH pituitary response is in no way affected by physiological variations in the plasma gonadal hormones. This independent behaviour of the TSH response, uninfluenced by gonadal activity, was apparently confirmed by the results in some pathological conditions (ovarian agenesis and primary male hypogonadism of various types) characterized by very low plasma levels of gonadal hormones.

Adolescent↗
PubMedDate not supplied

[Peripheral androgen resistance syndrome].

Two main topics of 5 alpha reductase deficiency and androgen receptors defects have been considered. Particularly, the differential diagnosis among the different syndromes of androgen resistance and the important issue of sex assignment are discussed.

Cholestenone 5 alpha-Reductase↗
PubMedDate not supplied

Juvenile rheumatoid arthritis in Turner's syndrome.

An increased risk for autoimmune diseases has been recognized in Turner's syndrome (T.S.). However autoimmune rheumatic or connective tissue disorders have not been described. We report here on a 8-8/12 year old caucasian girl with T.S. and Juvenile Rheumatoid Arthritis (JRA). The hypothesis that the association is more than casual is discussed.

Arthritis, Juvenile↗
PubMedDate not supplied

[Somatostatin].

Explore the source record for details and available documents.

Animals↗
PubMedDate not supplied

[Leydig cell function in cryptorchid boys (author's transl)].

Testicular endocrine function was assessed in 54 cryptorchid boys, 9 of whom had previously been treated with human chorionic gonadotrophin (HCG). Two different HCG tests were used, the first being short (5,000 IU/m2) and the second more prolonged (3 x 1,500 IU). The testosterone response to the two tests is both quantitatively and qualitatively different. HCG therapy abolishes the differences between cryptorchid boys and controls, which may explain the conflicting results of HCG tests in literature. The results also suggest that the absence of the late testosterone response during the short test in the cryptorchid boys not treated with HCG is due to a reduced and exhaustable Leydig cell function.

Child↗
PubMedDate not supplied

[Treatment by human chorionic gonadotropin in maldescended testes. (Synthesis of our experience)].

87 prepuberal children, 2-15 years old, 58 with unilateral and 29 with bilateral cryptorchidism, were treated intramuscularly with Human Chorionic Gonadotropin (HCG). HCG was administered in 16 children in single dose (5.000 IU/m2), in 11 children every other day for one week (3 x 1,500 IU) and in 60 children twice a week (2 x 1,000 IU) for 3-7 weeks. Treatment was successful in 31% of children. The most effective HCG dosage ranged between 10,000 and 14,000 IU (2 x 1,000 IU once a week for 5-7 weeks). The best therapeutic response was obtained in inguinal cryptorchid testes (39,3%), in unilateral cryptorchidism (34,5%) and in children aged 5-10 years (42,3%). The observed androgenic side effects (32%) subsided within 3-12 months after therapy suspension. The HCG therapy appears of particular value in cryptorchidism treatment. Surgical management is indicated in cases of true ectopic testes and after failure of HCG therapy.

Adolescent↗
PubMedDate not supplied

[Hemodynamic study of pulmonary vascular resistances in subjects with Down's syndrome with atrioventricular canal].

Down patients frequently present congenital heart disease (CHD). Among these the most common is complete atrioventricular canal (CAV). The Authors studied by cardiac catheterization 2 groups of subjects with CAV:21 Down-patients, aged 5-48 months (mean = 24.7) and 17 non-Down patients aged 6-50 months (mean = 23.1). Hemodynamic data were compared and in particular pulmonary vascular resistances (PVR) were analysed. Mean pulmonary resistance was 11.1 UM2 for Down children and 4.6 UM2 for non-Down children. Considering the subjects under 2 years of age, PVR greater than or equal to 10 UM2 was present in 5 of 14 (35.7%). Down children, while none in the non-Down group. The cause of this behaviour is unknown; some Authors, in pathological studies, found in Down-patients primitive structural anomalies of the vascular bed with decrease of total vascular surface area. This fact might explain higher values of PVR in Down-patients than in non-Down patients.

Child, Preschool↗
PubMedDate not supplied

[Micropenis. Results of treatment with testosterone].

Two groups of children presenting with micropenis (penis length less than or equal to 2.5 cm) were treated according to 2 different therapeutic schedules. The first consisted of the transcutaneous administration of testosterone propionate (4 mg twice a day) and the second of the intramuscular injection of sustained action testosterone enanthate (25 mg every 2 weeks). Only the intramuscular treatment was able to induce a normal and durable penis growth, owing to the hyperplastic action that the testosterone injection exerted on the level of the cellular tissues of the penis. Using testosterone enanthate dosages varying from 25 to 50 mg, the risks for an abnormal acceleration of growth and bone age seem to be minimized.

Administration, Topical↗