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Biomedical subjects

G Gillespie

Publications and source records attributed to G Gillespie.

At least 91 records · Page 5Linked to original sources
PubMed1989

Maintenance cimetidine instead of surgery for duodenal ulcer: the first decade.

Fifty five patients with severe longstanding dyspepsia originally selected as candidates for elective duodenal ulcer surgery were instead entered into a maintenance cimetidine study. Forty six have been reviewed after 10 years. Twenty patients had required surgery, all in the first three years, but six of them had proven or suspected recurrent ulceration during follow up. Twenty six patients avoided surgery, either with continuous cimetidine 400 mg nocte or intermittent full dose cimetidine. Of the 17 on continuous maintenance cimetidine, six had proven or suspected recurrent ulceration responding to full dose cimetidine. All nine patients on intermittent cimetidine experienced symptomatic relapse within eight to 12 weeks of drug withdrawal. By using cimetidine, 64% of patients selected for surgery have avoided operation over this 10 year period, although none has had drug free remission.

Adult↗
PubMed1989

Lights and lattices and where they are seen.

The article discusses characteristics of internal visual images and is based on personal observations of lucid dream and hypnopompic phenomena. In the context of lucid dreaming there sometimes occur persisting bright lights that do not behave like ordinary dream images. These phenomena appear as areas of light, peripheral light, disks of light, sun-like concentrations of light, and fullness of light. These luminous phenomena remain in a fixed location in my view in spite of any dreamed body movement, may appear in different dreams in the same locations, are not truly representational, and appear to be unrelated to other dream images, visual or otherwise. These stable intense lights remain in a fixed location in relation to an area defined by keeping the head still and moving the eyes. This area is the space that is filled at times by scannable hypnopompic geometrical patterns or scannable hypnagogic complex images. Although space-filling patterns look like they extend like a dome over the eyes, a close examination shows that they have a two-dimensional flatness that reaches over the entire scannable area. The observation of these patterns as flat becomes understandable when we think of the internal image as having no distance or separation from the seeing of the image, that is, as being experienced face on at every point. The flatness of the hypnopompic pattern implies the flatness of all internal images. The experiences translates the flat image to external positions around the eyes. This translation is explained.

Dreams↗
PubMed1986

Operative transampullary extraction of pancreatic calculi.

Transduodenal sphincteroplasty (TDS) was performed upon five patients with chronic pancreatitis shown on endoscopic retrograde cholangiopancreatography to have stones in the pancreatic ductal system. Stone removal was achieved after TDS using either a Fogarty balloon catheter, a Dormia basket or surgical forceps. All had suffered from a two to three year history of severe pain and weight loss which was relieved in each after stone removal. One patient suffered recurrent pain in the follow-up period of 21 to 45 months (a median of 35 months) and a recurrent stone in the pancreatic duct was removed endoscopically using a Dormia basket. Contrary to widely held views, TDS and simple stone extraction have a place in the management of some patients with chronic pancreatitis.

Adult↗
PubMed1984

The 3'-untranslated sequence of human skeletal muscle alpha-actin mRNA.

A human actin cDNA clone pGF3 isolated from a fetal skeletal muscle cDNA library is described. The insert cDNA is homologous to skeletal muscle alpha-actin as judged by restriction mapping and nucleotide sequencing. The recombinant contains a substantial portion of the coding and the complete 3'-untranslated region. Comparison of the 3' ends of human and rat skeletal muscle and human cardiac alpha-actins reveals little homology between different types of actin genes in man but marked conservation of this region in the skeletal muscle actins of man and rat.

Actins↗
PubMed1984

The early diagnosis of acute gall-bladder disease: the accuracy of overnight eight-hour infusion cholangiography.

The reliability of overnight 8-hour infusion cholangiography in confirming the diagnosis of acute cholecystitis or biliary colic was assessed by a prospective study in 100 patients. 55 positive infusion cholangiograms were subsequently confirmed at operation in 45 patients and by cholecystogram in 10 patients who did not have surgical treatment. The absence of false positive examinations is of fundamental importance if early cholecystectomy is to be performed without the risk of an unnecessary laparotomy. Infusion cholangiography proved to be a safe, simple and reliable investigation in the confirmation of acute gall-bladder disease.

Acute Disease↗
PubMed1983

Metronidazole prophylaxis in colorectal surgery: the need for additional aminoglycoside?

A randomized double-blind trial was conducted in two phases to compare the efficacy of prophylactic oral and intravenous administration of kanamycin and metronidazole in preventing wound infection and other complications in patients undergoing colorectal surgery, and also to assess the need for inclusion of an aminoglycoside in the prophylactic regimen. Adequate prophylaxis did not depend on the route of antimicrobial administration, but wound infection rates were increased following exclusion of kanamycin.

Aged↗
PubMed1981

Solitary ulcer of the rectum--or is it? A report of 6 cases.

Solitary ulcer of the rectum is an unusual disorder which presents only occasionally to the individual clinician. While the histopathological features are characteristic, the wide variety of naked eye appearances of lesions which the syndrome produces may make for clinical confusion, particularly since the lesions may be neither solitary nor ulcerated. We present to the Victoria Infirmary, Glasgow, over the period 1969-79 which illustrate the diagnosis dilemma and variety of lesions encountered.

Adult↗
PubMed1981

Specific and nonspecific immune factors in dental plaque fluid and saliva from young and old populations.

Separate samples of supragingival dental plaque overtly free of blood were centrifuged to obtain the free fluid phase (plaque fluid). Bound protein was eluted from the plaque bacteria and matrix by washing the plaque with a low-pH buffer. The plaque fluid, low pH eluate, and whole saliva were assayed for immunoglobulins A, G, and M, the third component of complement, lysozyme, lactoferrin, and lactoperoxidase. Concentrations of total protein and albumin were also determined. Antibody reactive with specific plaque bacteria was detected by indirect immunofluorescent microscopy. Specific and nonspecific immune proteins were present in plaque fluid from adult subjects at significantly greater concentrations than in their saliva, which suggests that these proteins are concentrated in dental plaque. The results indicate that both saliva and gingival exudate contribute to the immunological proteins found in the free fluid phase of dental plaque. The observation that immunoglobulin A antibody reactive with plaque bacteria could be detected in plaque fluid suggests that a wide variety of immunological reactions may occur in the dental plaque. These potential interactions between host, plaque bacteria, and their products could serve to influence the plaque flora and its ability to induce disease.

Aged↗