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Biomedical subjects

G Giebel

Publications and source records attributed to G Giebel.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Delayed fracture healing of the upper arm].

The analysis of 35 cases of delayed healing of fractures of the upper arm treated from 1981 to 1990 shows that fractures resulting from road accidents (16/35) and comminuted fractures (16/35) are particularly frequent in this group. Delayed fracture healing after conservative treatment (10 patients) was caused mainly by inadequate reduction (4/10) or by the fact that the conservative treatment performed was in fact inappropriate (4/10). Primary osteosynthesis was performed in 25 patients. Inadequate stabilization (9/25) was the most frequent reason for delayed healing, followed by the omission of bone grafting (7/25).

Adolescent↗
PubMed1990

Experimental glueing of injured spleen by collagen glue.

This paper discusses the suitability of collagen adhesive for the treatment of a ruptured spleen, and presents a preliminary study on 20 Sprague Dawley rats. Results indicate that this system should be further investigated for clinical applications.

Animals↗
PubMed1990

Toxicological aspects of synthetic tissue adhesives.

Generally, in order to be able to conduct clinical trials or to obtain a product licence for adhesives, toxicological studies have to be conducted in such a way as to provide sufficient data to be able to assess the toxicity, i.e. the risk. This paper discusses the types of studies which may be needed to fulfill these requirements.

Animals↗
PubMed1990

[Synovectomy in knee infection. Late results].

When short-term conventional treatment of pyogenic knee-joint infections does not relieve the symptoms, in most cases the patients can be cured with an synovectomy within a few weeks. In this procedure, the infected site, the synovial membrane, is excised. Immediately after the operation, functional treatment starts to improve joint mobility and cartilage nutrition. Of 17 synovectomies followed up after an average of 9.5 years, 10 were free of pain, 13 patients were able to walk without restriction, 12 could flex their knee more than 120 degrees, and 9 knees showed no radiographic signs of osteoarthritis. This 10-year follow-up shows that early synovectomy and functional treatment can lead to good long-term results. Therefore, this procedure can be recommended.

Adult↗
PubMed1989

[Osteosynthesis procedures in microsurgery].

In microsurgery the indications and techniques of osteosynthesis are often different from normal orthopaedic surgery. Simple methods which do not require much time or metal and which guarantee sufficient stability and minimal soft-tissue trauma are preferable. The external fixator has a good indication in the tibia and the plate osteosynthesis in the upper extremity and in the femur. Kirschner wires are useful in peripheral osteosyntheses.

Arm↗
PubMed1987

[Lengthening of the extremities and treatment of segmental defects by callus distraction].

Under certain conditions after osteotomy, continuous distraction of the bone ends can induce regeneration of bone tissue with bridging of the defect. This method has been used by Ilizarov for over 30 years and has proved very useful in lengthening procedures of the extremities and curing segmental defects. Particularly large defects (over 5 cm) may be bridged much faster than by conventional methods with repeated bone grafting. In many cases a single surgical procedure will suffice.

Bone Lengthening↗
PubMed1986

Radioimmunoassay for human osteocalcin using an antibody raised against the synthetic human (h37-49) sequence.

Radioiodination of synthetic human 37-49 osteocalcin requires optimal labeling conditions in order to obtain a maximum of mono- and di-iodinated tracer with little contamination by tri- and tetra-iodinated products or "radio-damage." The antibody raised against osteocalcin(h37-49) had the highest affinity for the C-terminal peptide used for iodination and the larger peptide (h30-49). The intact bovine osteocalcin (b1-49) revealed less immunoreactivity. This C-terminal specific radioimmunoassay detected the intact human osteocalcin in HPLC purified plasma and peritoneal dialysate from patients with terminal renal insufficiency and in extracted human bone. Some quantities of osteocalcin peptides with a higher hydrophobicity were predominantly detected in uremic plasma. These peptides that had a higher molecular weight than the intact human molecule might represent aggregated forms of the intact bone-derived osteocalcin. Immunoreactivity in plasma samples from healthy individuals revealed a remarkable difference as to which substance was employed for anticoagulation. Compared to heparin, the addition of EDTA largely reduced the osteocalcin immunoreactivity, implying that conformational changes within the N-terminal portion (containing the Gla- and Cys-residues) are extended to the C-terminal portion.

Antibodies↗
PubMed1986

Sonography and NMR imaging in rheumatoid gonarthritis.

Sonography and NMR imaging of the knee joint make it possible to obtain a visual representation of the thickened synovial membrane occurring in patients with rheumatoid gonarthritis, even before inflammatory deformation is radiologically detectable. Both methods can expose effusions and Baker's cysts. In NMR imaging, an indication of the inflammatory genesis can be obtained from the extended relaxation time T1. Due to the good representation of soft tissues, prognostic evidence may be gained of whether a mainly exudative or proliferative form is present.

Adult↗
PubMed1984

Synovectomy as treatment for purulent joint infection.

Conventional treatment of pyogenic knee joint infections leads to unsatisfactory results. Through early synovectomy, before cartilage damage and osteoarthritis appear, the infected focus can be "excised." Functional after-treatment avoids cartilage atrophy, wound adhesions, and muscle weakness. The excellent results after 26 knee joint infections confirm this.

Adolescent↗
PubMed1984

[Disorders of fracture and osteotomy healing. An analysis of aseptic complications].

The analysis of aseptic complications of bone healing shows that after conservative treatment failures are based mainly on an inadequate indication (37 of 68 patients). An operative procedure would have been better in these cases. Insufficient and recurrent reductions (11 of 68 patients) as well as over-extension with diastasis (9 patients) were less frequent. Osteosyntheses without bone healing were very frequent after failures in the operative technique (92 of 219 patients) and when bone defects (56 patients) remained. It is generally noticed that there is a relatively small number of bone healing problems following intramedullary nailing (13 patients) compared with plate osteosynthesis (119 patients). Both techniques are separately analyzed concerning the kinds of complications. Therapeutic priorities for the treatment of fractures are derivated.

Bone Plates↗
PubMed1984

[Infected joint fracture. Diagnosis, treatment and results in 63 patients].

For diagnosis, treatment and prognosis of infected articular fractures special attention should be paid to the following: When conventional treatment with puncture and irrigation of the joint after a maximum of 7 days is not successful, synovectomy in the early stage of infection, before extensive cartilage destruction particularly in the knee, elbow joint and hand, is the appropriate treatment. The progressive destruction of the cartilage and bone is interrupted. As a result of the early functional after-treatment good mobility of the joint and cartilage nutrition are achieved. In patients who were treated with synovectomy the time for healing was only 4 months, after arthrectomy 7 months and arthrodesis 20 months. Taking into consideration the complaints, mobility and shortening of the leg synovectomies had better results. The overall result demonstrates that despite enormous therapeutic effort, the infection in articular fractures is a serious complication which often leads to permanently functional deficiencies. Of 55 re-examined patients 34 were free of complaints, 5 amputations were necessary as a result of severe neurovascular damage and sepsis. The best results were achieved with early synovectomy.

Adolescent↗