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Biomedical subjects

G Geraud

Publications and source records attributed to G Geraud.

At least 37 records · Page 2Linked to original sources
PubMed1984

In situ distribution in different cell types of nuclear glycoconjugates detected by two lectins.

Nuclear glycoconjugates were detected in situ by two lectins--Concanavalin A and Wheat germ agglutinin--on tissue sections embedded in the hydrophilic resin glycol methacrylate. These lectins were conjugated with fluorescein isothiocyanate for fluorescence microscopy, and labelled with ferritin for electron microscopy. The ovarian follicle of the lizard Lacerta vivipara was chosen for this study, because it enables four types of nuclei, with different ultrastructures and physiology to be observed on the same section. In this material, all the nucleoli were found to contain a high concentration of receptors for both lectins. The distribution of the receptors located in the chromatin and nucleoli was observed to vary within the same type of nucleus, depending on the lectin used. Some of our results suggest that increased labelling by Wheat germ agglutinin might depend on increased production of ribosomal precursors.

Animals↗
PubMed1983

[Antimitotic chemotherapy of supratentorial cerebral glioma in adults. Apropos of 56 cases].

Fifty-six patients with supratentorial gliomas were given chemotherapy (VM 26 and CCNU). Results were analyzed and compared to recent data from the medical literature. After the first great expectations the place of chemotherapy in the management of primary gliomas has now been more accurately delineated: it is an adjunctive therapy, complementary to surgery and radiotherapy. The contribution of chemotherapy, although slight, is unquestionable: in 2/3 of cases a significant improvement of the length of survival can be expected.

Adult↗
PubMed1983

[The place of type I familial amyloid neuropathy in amylosis. Anatomo-clinical study of a case in France].

The clinical and pathologic findings of a case of amyloidogenic heredo familial neuropathy type I is presented. The patient is a man, died at 46 years. The examination of a nerve biopsy, the clinical evolution and the family history are representative of the condition. The study of autopsy material revealed amyloïd deposits within vessels walls, autonomic nerves of almost all viscera but liver, muscle and skin, around myofibers in the heart. Kidney glomeruli were markedly involved and numerous obsolescent glomeruli were seen. Lesions of central nervous system were of interest: enlargement of meningeal vessels walls due to amyloïd deposits as subpial deposition band were observed. The pattern of amyloïd deposits within peripherical nerves was quite different according to their proximal or distal ends. While distal amyloïd deposits were scant, nerve damages were striking. In proximal portions, amyloïdosis could be found in all layers of nerve structures including the walls of endoneural small vessels. Semi-thin sections allowed to observe rare myelinated fibers entrapped by aggregates of a microfibrillary material. While there was absence of a patent axonal lesion, clusters of regenerating fibers were not infrequent. Ultrastructural study confirmed the close relationship between amyloïd fibrils, Schwann cell basal laminae and collagen fibers. An immunopathological study using immunserums raised against the AA composant of amyloïdosis, K and lambda light chains, and prealbumin were negative. Our results are in agreement with descriptions already reported in the medical literature. Therefore, they allow to discuss already known pathogenic mechanisms for this rare affection transmitted by a dominant autosomic gene.

Adult↗
PubMed1982

[Fulminant infection in a splenectomized patient with Hodgkin disease. Fatal pneumococcal meningitis in a cured patient seven years after splenectomy].

Ten years ago, because of the increasing number of patients recovering from Hodgkin disease, some authors advocated systematic laparotomy with splenectomy for more accurate staging in order to adjust therapy with more precision. This attitude now seems questionable because of the occurence of several complications, particularly of life-threatening infections, which can be fatal even after recovery from Hodgkin disease. The case of a twenty-three-year-old male patient with Hodgkin disease stage III A, histological grade I, is reported. MOPP chemotherapy, splenectomy and cobalt radiotherapy were followed by complete recovery. Seven years later the patient died from fulminant pneumococcal meningitis. A review of previously published cases show that prolonged prophylaxis with oral penicillin is mandatory in splenectomized patients. Immunization with the pneumococcal polysaccharide vaccine should be attempted even though the long-term results are still unknown.

Adult↗
PubMed1978

Hemodynamic and metabolic factors in human cerebral ischemia.

Hemodynamic and metabolic cerebral measurements (CBF, CMRO2, CMRG, CSF) were evaluated in stroke patients. To investigate the effects of chronic cerebral circulatory insufficiency, CBF and CMRO2 were also studied. Further nontraumatic investigations of CBF measurement will allow a better understanding of clinical cases.

Acidosis↗
PubMed1975

Angiographic demonstration of the cervical vertebral venous plexus in man.

Opacification of the cervical vertebral venous plexus was achieved by injecting contrast material into the upper part of the internal jugular vein while the lower portion of this vein was compressed externally with a tourniquet. The injection was easily performed via a percutaneous catheter which was advanced upwards into the jugular vein. Demonstration of the cervical plexus is made easier with the patients sitting up. Both sides of the plexus may be shown with a single injection if both jugular veins are injected simultaneously through bilateral catheters joined with a Y connector.

Animals↗