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Biomedical subjects

G Gau

Publications and source records attributed to G Gau.

9 recordsLinked to original sources
PubMed1991

The effect of intrauterine intravascular blood transfusion on iron metabolism in fetuses with Rh alloimmunization.

Fetal plasma ferritin concentrations were measured in 43 normal fetuses at 18-36 weeks and in 78 blood samples collected before transfusion from 23 fetuses with Rh alloimmunization. Among controls, there was a significant correlation between fetal serum ferritin and gestational age (r = 0.39, P = .009), consistent with an increase in fetal storage of iron during normal pregnancy. In Rh-alloimmunized fetuses, the ferritin concentration was above the reference range in 63% of the samples. Before the first transfusion, the fetal ferritin concentration was increased compared with controls (mean multiples of the mean = 2.6, range 1-26) and showed a negative correlation with fetal hematocrit (r = -0.43, P less than .05), suggesting that the worse the fetal anemia, the higher the iron store. Serial transfusions were associated with further increase in serum ferritin, which correlated primarily with the total volume of blood transfused. Three fetuses had plasma serum ferritin concentrations above 1 mg/L, a level compatible with a diagnosis of iron overload in children. These observations suggest that there is a potential risk of iron overload in Rh-alloimmunized fetuses undergoing intrauterine blood transfusion.

Blood Transfusion, Intrauterine↗
PubMed1977

The ultimate audit.

The necropsy diagnoses in 78 stillborn and young infants have been compared with the clinical diagnoses in an attempt to justify post-morten examination in this age group. Clinical diagnosis was confirmed in over 88% of cases but unexpected changes in diagnosis were made in six cases, which indicates that selection is of no value.

Autopsy↗
PubMed1976

Location of the protein hormones of the placenta by the immunoperoxidase technique.

An attempt has been made to locate human placental lactogen (HPL) and human chorionic gonadotrophin (HCG) in cells within the human term placenta. Using immunoperoxidase techniques on frozen sections of tissue, no difference could be found between specific antisera and control sera. A theory is put forward that it may not be possible to visualize these hormones in the placenta using present immunoperoxidase techniques.

Chorionic Gonadotropin↗
PubMed1975

The distribution of placental lactogen in the human term placenta.

Serial frozen sections of human term placentae were examined by quantitative morphology and, after extraction, by a radioimmunoassay for human placental lactogen (HPL). The total quantity of HPL in the placenta was estimated as 720 mg. The amount of HPL was related to the amount of trophoblast in any area, but otherwise did not vary in different parts of the placenta. A semi-logarithmic relationship was observed between the amount of HPL and the percentage trophoblast in a section. It is suggested that the amount of HPL in a given area of the placenta is related to the blood-flow in that area.

Cell Count↗