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Biomedical subjects

G Garavaglia

Publications and source records attributed to G Garavaglia.

24 records · Page 2Linked to original sources

[Changes in HDL-cholesterol, subfractions HDL2 and HDL3 and apo-A, apo-A1 and apo-B lipoproteins in patients with chronic renal failure subjected to maintenance hemodialysis].

Hyperlipoproteinemia was found in 200 patients affected by chronic renal failure on maintenance hemodialysis, due to increase in Total Cholesterol, VLDL-TG, LDL, TG, LDL and VLDL. In 30 of these patients, the analysis was extended to the dosing of decreased Total Serum HDL-Cholesterol, HDL2, HDL3, Apoprotein A and Apoprotein A1 values, and of increased Apoprotein B values. These findings further contribute to proving accelerated atherogenesis in the patients examined.

Adult↗

Disparate cardiac effects of afterload reduction in hypertension.

Cardiac performance, as judged by preload, afterload, and myocardial contractility, was evaluated by non-invasive M-mode echocardiography before and after acute oral administration of calcium entry blockers (nitrendipine and verapamil), angiotensin converting enzyme (ACE) inhibitors (captopril and lisinopril), and a dopamine receptor agonist (fenoldopam) in patients with mild to moderate essential hypertension. Left ventricular end diastolic volume was taken as an index of preload, end systolic stress as an index of afterload, and the ratio of systolic pressure to end systolic volume (SBP:ESV), ejection fraction (EF), and mean velocity of circumferential fibre shortening (Vcf) as indices of contractility. Reductions of afterload and mean arterial pressure were achieved with all antihypertensive agents involved (mean percentage change +/- s.e.m.: 15 +/- 2% and 10 +/- 1%, respectively, P < 0.05) but the afterload reduction with lisinopril was greatest (21 +/- 9%; P < 0.01). The dopamine receptor agonist fenoldopam decreased by preload 24% (P < 0.05) and increased all of the three parameters of myocardial contractility (SBP:SV 66%; EF 17%, Vcf 19%; P < 0.01). In contrast, no effect on these parameters was observed with either calcium entry blocker or either ACE inhibitor.

Adult↗

Measurement of lead content of children's teeth in situ by x-ray fluorescence.

The central nervous system of young children is particularly sensitive to neurological damage due to excessive lead exposure. The lead stored in a tooth is permanent and related to the quantity of ingested lead. The lead is assayed by measuring the characterisitc radiation from lead in a tooth in situ irradiated with gamma rays from a cobalt-57 source. The sensitivity of the method is adequate to measure lead levels commonly associated with environmental background. The X-ray exposure to the tooth necessary for this determination is approximately one tenth of that required for a routine dental examination.

Child↗

Field separation of adjoining therapy fields.

The question of optimal portal separation between two contiguous fields is of importance in radiotherapy. An analytical linear model based on experimental data has been developed for a Co-60 unit (Siemens Gammatron S 65 K). It allows the computation of the separation distance for any combination of field sizes not necessarily having the same source-surface-distance, defined either with penumbra trimmers or focused shaping blocks.

Cobalt Radioisotopes↗