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Biomedical subjects

G Gamba

Publications and source records attributed to G Gamba.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Effect of a bioflavinoid (4-methylesculetin) on the response of calf hepatic arteries to serotonin in the presence of indomethacin].

The aim of this work is to study the mechanism by which 4-methylsculetin (4-Me) inhibits the serotonin induced contraction in smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and serotonin induced contraction of isolated hepatic artery strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin-synthetase. IN suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release smooth muscle.

Animals↗
PubMed1983

[Effect of a flavinoid (4-methylesculetin) on the response of isolated calf coronary arteries to histamine in the presence of indomethacin].

The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) cause the relaxation or inhibit the histamine induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and histamine induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the histamine dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.

Animals↗
PubMed1983

[Response of isolated coronary artery segments to serotonin in the presence of a flavinoid, indomethacin and acetylsalicylate].

The aim of this work is to study the mechanism by which 4-metilesculetin (4-Me) cause the relaxation or inhibit the serotonin induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and serotonin induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.

Animals↗
PubMed1983

[Dissecting aneurysm of the thoracic aorta with paraplegic onset. Diagnosis using computerized tomography].

A case of dissecting aneurysm of the thoracic aorta (De Bakey type III) which first presented as paraplegia of the lower extremities, and the diagnosis of which was confirmed by computerised tomography, is reported. Examination of the literature confirms the rarity of neurological complications especially as an initial symptom. The ischaemia involving areas supplied by the intercostal arteries must be the pathogenetic mechanism of both the paraplegia and the significant increase in sero-enzymes (CPK-MB). The case observed confirms the opinion of other authors that computerised tomography permits rapid diagnosis. As it is also easily performed and not invasive it represents an alternative to conventional angiography.

Aged↗
PubMed1983

[Responses of isolated hepatic artery segments to barium in the presence of a flavonoid (4-methylesculetin), indomethacin and acetylsalicylate].

The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) inhibits the Ba++ induced contraction in smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and Ba++ induced contraction of isolated hepatic artery strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN suppressed the depressive effect of 4-Me on the Ba++ dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release smooth muscle.

Animals↗
PubMed1983

Interactions between neoplastic cells with different metastasizing capacity and platelet function.

We have examined the effects on platelet function of two sublines (M4 and M9) derived from spontaneous lung nodules of a benzopyrene-induced murine fibrosarcoma (m FS6). The subline M4 was more metastatic and the subline M9 less metastatic than the primary tumour. Only the more malignant cells were able to induce irreversible aggregation of human platelets; this effect was concentration-dependent and was associated with the release of serotonin by platelets. Both aggregation and release were inhibited by preincubation of platelets with ASA, not by preincubation of the cells. The supernatants of cell suspensions had no aggregating activity. However, the neoplastic cells in culture media released an activity directly stimulating platelet aggregation and potentiating the platelet response to ADP; again, this activity was higher for the more malignant cells and the effects were inhibited by preincubation of platelets with ASA. These results suggest a role for platelets in the development of tumour metastases.

Adenosine Diphosphate↗
PubMed1982

[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. I. Human tumors of the gastrointestinal tract].

The effects on platelet function of culture media from 7 human tumours of the gastroenteric tract have been studied on platelet rich plasma obtained from 28 apparently normal subjects. Platelet aggregation was investigated according to Born's method. Some of the culture media showed an aggregating activity on platelets, while others did not; after dialysis, however, also the last ones aggregated platelets. Furthermore all the media both before and after dialysis were able to increase the platelet response to low doses of ADP (3 microM), and these effects were inhibited by Aspirin (0,1 mM). These results suggest that the tumours investigated release stimulating activities on platelet function and that these interactions can be inhibited pharmacologically.

Adenosine Diphosphate↗
PubMed1982

[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. II. Experimental tumors].

We have investigated the effects on platelet function of culture media from 2 sublines of a benzopyrene-induced murine sarcoma (mFS6). Platelet aggregation was investigated according to Born's method. The cell line with greater "in vivo" invasiveness showed higher aggregating activity and higher increase on ADP-induced aggregation; these effects were inhibited by the preincubation of platelets with Aspirin (0,1 mM). These results suggest the role of platelets in metastasis formation; the possibility to inhibit pharmacologically the interactions between platelets and tumour cells could have important implications from both speculative and practical viewpoints.

Adenosine Diphosphate↗
PubMed1981

Synoviorthesis versus synovectomy in the treatment of recurrent haemophilic haemarthrosis: long-term evaluation.

The authors report a long-term evaluation of the effects of chemical and surgical synovectomies performed in two groups of patients which were comparable as regards number of haemarthrosis per year and joint mobility. The results obtained indicated that both synovectomy and synoviorthesis were effective in reducing the bleeding episodes; however, while synovectomy stopped almost completely the recurrence of haemarthrosis, synoviorthesis in 3 patients younger than 12 years did not modify it and in one case it even increased the bleeding tendency. Moreover, the occurrence of arthritic pain was observed in 6 knees treated by synoviorthesis and only in 3 knees treated by synovectomy. Finally, the joint function was significantly reduced in the synoviorthesis group as compared to the synovectomy group. In conclusion, synovectomy gave better results than synoviorthesis but the latter treatment has a number of economical and technical advantages and should therefore be considered in patients older than 12 year of age with good joint function and without evident radiological changes, in whom full dose replacement therapy has had no effect on the recurrence of haemarthrosis.

Adolescent↗
PubMed1981

Enhanced antithrombotic mechanisms in patients with maturity-onset diabetes mellitus without thromboembolic complications.

Some haemostatic parameters have been evaluated in a group of rigorously selected patients with maturity-onset diabetes mellitus without thromboembolic complications and in apparently normal subjects of the same age before and after the venous occlusion test (VOT). In basal conditions diabetics had higher levels of AT III as biological activity and higher fibrinolytic and antifibrinolytic activities than controls. After VOT, F VIII R:Ag increased significantly in both groups, more markedly in controls than in diabetics, while F VIII: C showed no modification. Also AT III R:Ag increased after the test, but such variation was significant only in diabetics; on the contrary, the biological activity of AT III was always significantly decreased after the test. After VOT there were also in both groups highly significant increases in the fibrinolytic and antifibrinolytic activities. Finally, HbA1c levels directly correlated with AT III as biological activity before VOT, but with no other parameter either before or after the test. These data suggest the existence in patients with diabetes mellitus without thromboembolic complications of an activated protective mechanism against intravascular clotting.

Aged↗