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Biomedical subjects

G Gallo

Publications and source records attributed to G Gallo.

247 records · Page 14Linked to original sources
PubMedDate not supplied

[Torticollis and neck tumors: presentation of a case].

Stiff neck in children is a quite frequent sign of various pathological processes, not always benign in nature. Here is referred the case of a extradural cervical tumor in which stiff neck, associated with nucal rigidity, was for a long time the only symptom of the underlying process. The association of cervical tumor with stiff neck as the only longlasting initial symptom has only sporadically been reported. The authors analyse the various causes of stiff neck from the clinical and anatomo-pathological viewpoints, including age of patient at onset.

Child, Preschool↗
PubMedDate not supplied

[Primary nephrotic syndrome. Follow-up of 202 pediatric patients].

Two hundred and two children with primary nephrotic syndrome were studied. Clinical features at onset and evolution were studied and correlated with microscopic findings and response to treatment. Histologic type and steroid-response were correlated with urinary protein selectivity in a group of them. Mean follow-up (by the same group of nephrologists) was 6.6 years; 22% were followed for over 8 years. The presence of hematuria, hypertension and renal failure at onset and during the course of the disease were evaluated. 122 patients were steroid-responders, 64 of them had frequent relapses. After a mean follow-up of 6.3 years, 81% were on remission; 14% had transient proteinuria, and 5% developed persistent proteinuria with late resistance to steroid therapy. 80 children were steroid-resistant. Their mean follow-up period was 5.5 years (1.0-10.5 years). 65 of them were biopsied: 12 had minimal glomerular change; 27 focal and segmental sclerosis. 9 membrano-proliferative glomerulonephritis, 4 focal and global sclerosis, 4 membranous nephropathy, 4 diffuse mesangial proliferation, 2 diffuse mesangial sclerosis and 2 were not classifiable. Hematuria had a prognostic value only when it was permanent or macroscopic. Urinary protein selectivity was measured in 43 patients, and C3 in 81; hypocomplementemia was found only in the 9 children with membranoproliferative glomerulonephritis. 8 children had tubular dysfunction: 7 had focal and segmental sclerosis, and 1 diffuse mesangial sclerosis; glycosuria and aminoaciduria were present in all 8, but only 4 of them had deficient urinary acidification. Secondary infections appeared in 42 patients; 19 were steroid-resistant and 23 steroid-responders, 17 of them showed frequent-relapses, 3 had localized thromboembolism. 23 children went into chronic renal failure and 17 of them died, 13 in end-stage renal failure and 4 because of complications. Their first biopsies showed minimal change in 1, focal and segmental sclerosis in 8, membranoproliferative glomerulonephritis in 3, diffuse mesangial proliferation in 1, diffuse sclerosis in 2, and 2 were not classifiable.

Adolescent↗
PubMedDate not supplied

[The current controversies over video laparoscopic cholecystectomy as the treatment of choice for cholelithiasis].

Recently, the widespread use of laparoscopic cholecystectomy allowed to reach several goals such as a minimal invasive approach, a minimal operative trauma, the absence of aesthetic or functional damage of the abdominal wall, and a quick return to full activities. On the other hand, as all innovations, laparoscopic cholecystectomy is matter of debate and a number of controversies have recently appeared in the Scientific Literature. On the basis of their experience and through a critical review of the Literature, the Authors have therefore analyzed possible solutions to such controversies. Particularly, current indications and contraindications of this approach, surgical technique and relative sites of insertion of the trocars, the need to drain or not, the pre- and intra-operative study of the bile duct and the approach in case of bile duct stones pre- or intra-operatively demonstrated, have been evaluated as possible answers. The Authors conclude that indications to laparoscopic cholecystectomy are the same of those for laparotomy, contraindications are represented by coagulopathies, liver cirrhosis and plastic peritonitis. At present it is still impossible to affirm which is the best surgical technique, the best position for the surgeon, and the best site for the insertion of the trocars, while drainage must be used only in those cases in which further manoeuvres on the bile duct are required. At last the Authors underline there is no need for a routine intraoperative cholangiography during laparoscopic cholecystectomy, however such technique must be known by laparoscopic surgeons since it may be mandatory in some selected cases. ERCP, on the contrary, is a valid support to laparoscopic cholecystectomy in the treatment of gallbladder stones associated with bile duct stones.

Adult↗
PubMedDate not supplied

[Ambulatory treatment of postphlebitic ulcers of lower limbs. Physiopathological bases and clinical results].

Venous ulceration is a troublesome and disabling complication, representing one of the most difficult problems to be treated by the vascular surgeon. Venous insufficiency is a widespread condition, the prevalence of venous ulceration being 0.5 - 1 per cent in European populations. Although all venous ulcers will heal if the limb is elevated above heart level for an extended period of time, patients need a safe, effective, not disabling and quick therapy. Hence, the competent vascular surgeon must be familiar with venous pathophysiology and possess a thorough understanding of the treatment options available for a discouraged patient in need of an acceptable and effective approach. The aim of the present study was to assess the efficacy and the speed of healing of venous ulcer using an outpatient ambulatory treatment protocol. This protocol consisted of elastic compression bandage allowing deambulation, local dressing using lyophilized heterologous collagen (Condress, Gentili) and systemic profibrinolytic drugs. Exclusion criteria were coexisting arterial insufficiency, ulcer area greater than 25 cm2, coexisting disabling diseases (congestive cardiac failure, hepatic insufficiency, malignancy). From December 1990 to June 1993, 37 patients affected by venous ulcer were treated, according to the aforementioned protocol, at the Surgical Department of Montecchio Maggiore Hospital (VI). There were 16 male and 21 female patients, mean age was 66 years (range 59-91). Results show the complete healing of the venous ulcer in 94.5% of patients; mean time for ulcer healing was 128 days (range 45-91). The Authors conclude that the outpatient ambulatory treatment protocol is safe, quick, and effective for the therapy of chronic venous ulcer; once obtained the healing of the ulcer, elastic compressive bandage with elastic stockings is mandatory to prevent recurrences.

Aged↗
PubMedDate not supplied

Relationship between DNA synthesis and growth factor expression in primary cultures of adult rat hepatocytes.

In this study we employed primary culture of adult rat hepatocytes to verify the effects of two different extracellular matrices (collagen, matrigel) on EGF-stimulated DNA synthesis and c-myc expression. Our results confirm that in adult rat hepatocytes EGF induces DNA synthesis, preceded by a transient increase of c-myc expression, when cells are cultured at low density on collagen. DNA synthesis appears to be in reciprocal relationship with hepatic expression of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-4, suggesting that IGF-I/IGFBPs system is not involved in liver growth.

Animals↗