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Biomedical subjects

G Galli

Publications and source records attributed to G Galli.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

[Thermal energy balance during hemodialysis: the role of the filter membrane].

BACKGROUND: Body temperature tends to increase during conventional haemodialysis; this might interfere with normal cardiovascular response to dialytic ultrafiltration, thus facilitating the occurrence of symptomatic hypotension. Putative factors responsible for changes in thermal balance during haemodialysis include heat load from the dialysis bath, reduction in convective heat loss secondary to skin vessel vasoconstriction, heat overproduction due to central stimulation by bioincompatibility reactions to the filter membranes. The aim of the present study was twofold: to define thermal energy balance (ET) during dialysis and to investigate the effect of membrane bioincompatibility on energy balance METHODS: We measured ET in 12 patients (9M, 3F) during two identical dialysis sessions, differing only in the membrane composition of the filters used: cuprophane 1.3- 1.6 mq and LF polysulphone 1.3- 1.6 mq. Thermal energy balance studies were performed by the Blood Temperature Monitor (Fresenius Medical Care) under conditions in which the core temperature of the patients was maintained unchanged from the start to the end of the dialysis procedure. RESULTS: Arterial blood temperatures were constant, while dialysate and venous blood temperatures progressively decreased (from 36.9 to 35.4 C and from 36.5 to 35.1 C for cuprophane; from 36.9 to 35.2 and from 36.9 to 35.1 for polysulphone membrane). Mean thermal energy transfer was negative (removal of energy from the patients to the extracorporeal circuit) with both filters, equal to 146 KJ with cuprophane and to 163 KJ with polysulphone. When a stepwise multiregression analysis was applied, hourly energy transfer (ET) was significantly and independently correlated with both ultrafiltration rate (UF=% b.w.) and heart rate changes (HR) according to the equation: ET= -92.03+41.29 UF+1.04 HR (p<0.0003). Conclusions. In this study we present experimental evidence that increased body temperature during dialysis is not caused by heat load from the dialysis bath, nor by heat over production secondary to bioincompatibility reactions. Consequently, haemodynamic responses to dialytic ultrafiltration may be regarded as the main regulatory factor of thermal balance.

Aged↗
PubMedDate not supplied

[Peripheral arteriopathy in ESRD dialysed patients: when and how to intervene].

Critical limb ischemia secondary to chronic peripheral occlusive disease is common in chronically dialysed patients, with an incidence rate of 25-30%. Atherosclerotic lesions are more frequent in the infrainguinal arteries and long infrapopliteal occlusions often occur. Due to diabetes, hypertension and ischemic cardiopathy, the surgical prognosis is very poor in these patients; medical treatment should always be attempted associated with analgesia, without an excessive delay in surgical therapy if needed. Both spinal stimulation and lumbar simpaticectomy often fail; open and endovascular surgery are the best options before major amputation, which has a high incidence in this patient subgroup. Between 2000 and 2003, 23 chronically dialysed patients underwent surgery. Nine open and 13 endovascular procedures were performed, associated with four immediate and five late minor amputations. Despite an immediate mortality rate of 8.6%, we obtained immediate patency and limb salvage in all cases. In a medium follow-up of 25 months (range 3-36), five thromboses were found in subinguinal procedures; not one in iliac procedures. The five patients underwent major amputation. Another two patients underwent amputation despite arterious patency. Seven patients died due to cardiovascular diseases during the follow-up. Our experience confirms that the association between POAD and dialysis is a prediction factor for medium-term death and that the surgical risk is highly increased. It is important to select patients undergoing surgical treatment to check for the lowest invasivity.

Aged↗
PubMedDate not supplied

99mTc-human immunoglobulin (HIG) in AIDS patients: first results.

Scintigraphy with 99mTc labelled human polyclonal immunoglobulin was performed in 16 patients with ascertained or suspected AIDS-related infections. 99mTc-HIG lung scanning was compared, in 11 patients, with 67Ga scintigraphy, chest X-ray and high resolution lung CT. 67Ga and 99mTc-HIG were concordantly positive in five cases of BAL-ascertained Pneumocystis carinii pneumonia (PCP), while one of them was Rx and CT negative. X-ray, 67Ga and 99mTc were concordantly negative in 5 cases. 99mTc-HIG yielded negative results in two cases of Mycobacterium infection, both of which were 67Ga and Rx positive: Mycobacterium avium in diffuse lung involvement and Mycobacterium TBC in excavated infiltrate. 99mTc-HIG was also positive in other 3 AIDS patients: 1 case of intestinal cryptosporidiosis, 1 pulmonary abscess (Staphylococcus and Candida), and 1 sacral abscess; it was negative in 1 case of Kaposi sarcoma (also 201Tl negative). In conclusion, 99mTc-HIG scintigraphy in AIDS patients is feasible, and offers some practical advantages (continuous availability, fast response time, etc.). The initial results seem similar to those of 67Ga in lung scanning (and perhaps more specific for PCP).

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

The Ilizarov method for the treatment of non-union in the humerus.

The authors report 7 cases of septic and aseptic pseudoarthrosis in the humerus, with or without tissue loss, treated with the Ilizarov apparatus. The method proved to be therapeutically effective, guaranteeing a short amount of time required for consolidation, with bone callus of the periosteal type which was abundant and mechanically effective, immediate functional recovery, and no important complications.

Biomechanical Phenomena↗
PubMedDate not supplied

Grosse-Kempf nailing in the elderly.

The authors report on 30 fractures of the femur and tibia treated with the Grosse-Kempf locked nail in patients aged more than 60 years. Neither nonunion nor severe complications were observed; surgical trauma was well sustained. Functional results were particularly satisfactory; most patients began walking within the first week after fixation.

Age Factors↗
PubMedDate not supplied

Tension pneumocephalus after transsphenoidal surgery for acromegaly.

The Authors report the case of a 27-year-old man who developed intraventricular and subarachnoid tension pneumocephalus after removal of a large pituitary adenoma via the transnasal approach. This exceptional complication was probably caused by the combined action of a cerebrospinal fluid fistula plus an external lumbar subarachnoid drain, and resolved after removal of the spinal catheter. Such a conservative treatment was allowed in this case by the absence of a shift of midline structures due to bilateral intraventricular air collection. Usually, however, tension pneumocephalus is a life-threatening condition that requires prompt intervention. Meticulous attention to the cerebrospinal fluid draining system is needed in patients with a fistula to avoid the development of this unusual complication.

Acromegaly↗