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Biomedical subjects

G Galletti

Publications and source records attributed to G Galletti.

At least 37 records · Page 2Linked to original sources
PubMed1985

Histopathological aspects of tissue reactivity to suture materials in microsurgical arterial, anastomosis.

In order to assess tissue reactivity to synthetic suture material in microsurgery, a histological study was carried out in 20 rabbits divided into two groups: "A" and "B". The aorta of the animals was sectioned and subsequently anastomosed using polyglycolic acid in the first group and monofilament nylon in the second group. The animals were sacrificed at 10, 20, 40, 60 and 90 days after surgery, and the specimens were studied both macroscopically and microscopically. Tissue reactivity during the initial 40 days had similar histological characteristics in both groups evidentiating a perisuture granuloma with macrophages and giant cells. The second period, 40 to 90 days after surgery, was characterized by a tissue reactivity specific for each type of suture. In group "A", the inflammatory process diminished in parallel to the absorbtion of polyglycolic acid with "restitutio ad integrum" of the vessel wall. In group "B", the inflammatory process persisted due to the presence of non absorbable monofilament nylon, thus causing a fibrosclerotic transformation of the vessel wall. The results of this study suggest that the most suitable suture material for anastomosing living tissues are absorbable sutures.

Animals↗
PubMed1984

[Not Available].

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History, Early Modern 1451-1600↗
PubMed1984

Comparison of the effects of polyglycolic acid and monofilament nylon sutures in the common bile duct of pigs.

The tissue reaction and involvement of cells in the common bile duct of young pigs after surgery with two suture materials, polyglycolic acid and monofilament nylon, have been described. By comparing the different tissue reactions to the suture materials the authors observe that the use of non-absorbable polymer sutures and their long lasting presence in living tissues, may interfere with the healing process, since the sutures tend to migrate within the common duct wall and be expelled into the lumen owing perhaps to the delayed immuno-allergic reaction which develops in the common duct wall. In contrast polyglycolic acid seems to be biologically well tolerated and well integrated as a suture material, which is reabsorbed with the help of cell enzymes producing a complete restitutio ad integrum of the wall.

Animals↗