Biomedical subjects
G Gallasch
Publications and source records attributed to G Gallasch.
[Early disorders of retinal function in diabetes mellitus].
Thirteen insulin-dependent diabetics, aged 13-30 (mean 19.15) years, entered the study. Patients with retinal ischemia, vascular proliferation, or a Snellen acuity below 0.8 were excluded. Ten normal untrained subjects, aged 20-30 (mean 24) years, provided the normal sample. The battery of special visual function tests consisted of: (1) high luminance Pflüger acuity (acuity/luminance/function, rotatable illiterate "E optotypes, screen luminance 10,000 cd/m2); (2) tests combining color vision with demands on spatial resolution: (a) blue-green chromatic acuity (a Velhagen pseudoisochromatic plate served as optotype, the maximum recognition distance being recorded); (b) standard vs mini-panel D-15 color-arrangement tests; (c) blue preferential computerized perimetry (modified Tübingen automatic perimeter, orange adaptive illumination, Schott cut-off filter OG 550, cupola luminance 5 cd/m2).(ABSTRACT TRUNCATED AT 250 WORDS)
[Segmental retinal arteritis and retinochorioiditis].
Acute ocular toxoplasmosis is characterized by a focal retinochoroidal infiltrate, often appearing in the immediate vicinity of an old retinochoroidal scar (satellite lesion). There are atypical forms of ocular toxoplasmosis, including retinal granulomas, intraretinal and subretinal neovascularization, preretinal gliosis and retinal detachment. In rare instances, associated immunological phenomena, i.e. concomitant vasculitis and perivasculitis, have been described. We report on a 28-year-old male patient presenting with signs of congenital toxoplasmosis with intracerebral calcifications and internal hydrocephalus (Whytt's disease). Ocular manifestations included an acute retinochoroidal infiltrate adjacent to a retinochoroidal scar and segmental retinal periarteritis. All arterioles were involved, but there was no inflammation of the venules. Fluorescein angiography revealed filling irregularities of the vessel segments involved. Like a tubercular patient with segmental periarteritis reported on as long ago as 1939, our patient had undergone treatment for active tuberculosis of the lung 6 years earlier. Considering the fact that segmental periarteritis without concomitant periphlebitis is very rarely seen, the coincidence of acute toxoplasmosis and previous tuberculosis suggests a complex immunological etiology of retinal vasculitis. This assumption may be supported by the fact that a combined systemic treatment with pyrimethamine, trimethoprim, sulfamethoxazole and prednisolone reduced the retinochoroidal inflammation and periarterial infiltrates.
Changes in degree of sclerosis as a function of prophylactic treatment in cancer-prone and CHD-prone probands.
One-hundred and ninety-two probands were selected on the basis of personality questionnaires as being cancer-prone (100) or CHD-prone (92). They were then randomly divided into a control and a treatment group, the latter receiving a special kind of behaviour therapy attempting to change the personality patterns in the direction of a healthier, more autonomous personality. Follow-up after 10 and 13 years disclosed significantly lower death rates in probands receiving prophylactic treatment than in controls. Of special interest was the degree of sclerosis in the fundus of the eye, rateds on a 3-point scale. This was significantly higher prior to therapy in the CHD-prone group than in the cancer-prone group. Treatment reduced the degree of sclerosis, particularly in the CHD group; lack of treatment was followed by an increase in sclerosis. Similar but less marked changes were found in the cancer-prone group. Clearly psychological treatment affects significantly bodily functions associated with CHD. Other risk factors considered were systolic and diastolic blood pressure, blood cholesterol and blood sugar, all of which, together with personality, influenced the degree of sclerosis observed.
Sport activity and personality as elements in preventing cancer and coronary heart disease.
Results are reported for 3 groups of healthy male probands, 318 in each group, matched for age and personality type on the Personality-Stress Questionnaire. One group was actively engaged in sports, one had discontinued former sporting activities, and one group had never taken part in regular sports. Follow-up after 13 yr. showed lowest mortality in those actively engaged in sport, highest mortality in those who had given up sport, with those who had never been engaged in sport intermediate. Prophylactic behaviour therapy was shown to reduce mortality of those who had given up sport to a significant extent but not to affect degree of retinal sclerosis.
[Diabetic retinopathy].
Explore the source record for details and available documents.
[Cholesterol granuloma of the orbits--clinicopathologic study].
Unilateral exophthalmos was caused by a cholesterol granuloma in a 42-year-old patient. The clinical picture, roentgenographic and NMR tomographic changes, surgical therapy and histopathological results are described and discussed with regard to the etiology and differential diagnosis of this disease.
Hypertension in diabetes mellitus.
Explore the source record for details and available documents.
[Rebound effects following isovolemic hemodilution in venous vascular occlusions and their prevention].
Explore the source record for details and available documents.
[Eye symptoms in dystonic-hyperkinetic syndrome].
Explore the source record for details and available documents.
[Effect of physical training on blood flow properties in patients with intermittent claudication].
Abnormal blood flow in patients with intermittent claudication can be normalized by physical training. We found a decrease in blood viscosity with a decrease in the erythrocyte-aggregation tendency and significant simultaneous improvement in erythrocyte filtrability. Improvement in these haemorheological properties led to a significant increase in physical performance after training. This positive result can be obtained by regular physical training; the application of rheologically effective medicaments is not necessary.
[Efficacy of troxerutin on the flow properties of blood under defined conditions of circulation. A double-blind study of patients with diabetic retinopathy and arteriosclerotic retinopathy].
In a clinically controlled double-blind study it was demonstrated that tri-(hydroxyethyl)-rutin is not capable of significantly improving blood viscosity or one of its constituent factors. On the basis of data from 58 patients, none of whom was under 43 years old, it was possible to show that the substance tested has no favorable influence on plasma viscosity, erythrocyte deformability and aggregation, or on the concentration of plasma proteins which promote aggregation. Thus, in the very group of patients for whom an improvement in blood flow properties by means of oral administration of tri-(hydroxyethyl)rutin had been hoped for, no therapeutic effect could be demonstrated.
[Results and indications for drug therapy in arterial and venous vascular occlusions of the retina due to erythrosclerosis].
Explore the source record for details and available documents.
[Herpetiform bilateral epithelial corneal dystrophy caused by Tyrosinemia (Richner-Hanhart-Syndrome) (author's transl)].
Nutritional Tyrosinemia in animal experiments (Schweizer, Burns a. o.) caused an epithelial corneal dystrophy. The corresponding clinical picture is the Richner-Hanhart-Syndrome with herpetiform epithelial corneal dystrophy, palmo-plantar-keratosis and -- in some case -- a later developing oligophrenia. Goldsmith and coworkers suceeded to find out that all these symptoms are combined with tyrosinemia presumably caused ty one congenital enzyme defect. -- Personal clinical observations of such patients demonstrate that as well the corneal as the dermatological symptoms could be cured by diet, if the diagnosis is made in childhood. Corneal symptoms are still absent with a tyrosinemia as high as 10 mg%. Dietetic formula was found out to maintain this level, which is low enough to avoid the symptoms of Richner-Hanhart-Syndrome and certainly high enough to avoid symptoms of nutritional deficiency. One might expect that oligophrenia will not develop if this diet is used consequently. -- Since the first corneal symptoms develop already during the first years of life the ophthalmologist ought to know this etiology. The levels of tyrosinemia are so exorbitant (30--50 mg%) that the laboratory diagnosis is possible without any difficulty. If the diagnosis is only made in adult patients dietetic therapy is of limited value.
[Tyrosinemia and Richner-Hanhart syndrome (an autosomal recessive hereditary metabolic disease of childhood with bilateral dendritic pseudokeratitis, keratosis palmaris et plantaris and mental deficiency)].
Explore the source record for details and available documents.
[Clinical aspects of pelvic stenosis syndrome (Schneider-Fischer)].
Six cases with posthrombotic obstruction of the pelvic veins are reported. These case reports demonstrate the variability of the clinical symptomatology. In addition relationships between the postthrombotic obstruction of the pelvic veins and hemorrhoids and varicocele are discussed. Therapeutical aspects are reviewed.
Pathological red cell aggregation (clump aggregation). Molecular and electrochemical factors.
Explore the source record for details and available documents.
Red cell aggregation in blood flow. I. New methods of quantification.
The rheological behavior of normal and pathological red cell aggregates in viscometric flow (artificial flow in cone plate chamber) is studied by direct microscopy, (rheoscopy) viscometry and photometry. Marked differences between normal and pathological blood are measured in the microrheological properties of red cell aggregates; only discreet differences are measured by blood viscometry (macrorheology). Both in normal and abnormal blood, red cell aggregation is a reversible process in the presence of adequate shear forces; their respective influences on apparent blood viscosity at low rates of shear are complex functions of shear rate, shear time, hematocrit and plasma viscosities. Pathological red cell aggregation (RCA) forms more rapidly and extensively than normal RCA. The pathological aggregates frequently have a tendency to grow at low rates of shear and they are highly shear resistant.