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Biomedical subjects

G Gadeholt

Publications and source records attributed to G Gadeholt.

At least 19 recordsLinked to original sources
PubMed1991

[Tablet strength and dosage of thiazides in hypertension must be reduced].

A number of studies indicate that hydrochlorothiazide doses above 50 mg daily provide little additional hypotensive effect but progressively greater hypokalemic effect. From these and similar studies on other thiazides a daily dose range for thiazides of 12.5-50 mg for hydrochlorothiazide, 1.25-5 mg for bendroflumethiazide, 1-2 mg for trichloromethiazide, 0.5-1 mg for polythiazide, and 6.25-25 mg for chlorthalidone appears to be sufficient. Because amiloride enhances the natriuretic effect of thiazides, this agent has not only a Mg2+/K(+)-sparkling effect, but also a potential thiazide-sparing effect. For this reason, the recommended doses of fixed combinations of hydrochlorothiazide and amiloride should be lowered to the range 6.25 mg/0.625 mg--25 mg/2.5 mg.

Benzothiadiazines↗
PubMed1991

[Dependence on carisoprodol (Somadril)? A prospective withdrawal study among prisoners].

Carisoprodol (Somadril) was gradually withdrawn for a fortnight in nine male prisoners who had been taking daily doses of from 700 to 2,100 mg for at least nine months. The patients were assessed clinically during the withdrawal period, with special attention to the occurrence of abstinence symptoms. Most of the patients reported mental distress, such as anxiety, insomnia and irritability. Cranial and muscular pain and vegetative symptoms were also frequently reported. Most of these symptoms were transient, and no seizures or psychotic reactions occurred. Our information from drug addicts indicates that carisoprodol can be misused as a narcotic. The occurrence of abstinence symptoms during withdrawal supports this supposition. We propose a more gradual reduction of the doses when terminating medication with carisoprodol in general practice.

Adult↗
PubMed1990

Proton nuclear magnetic resonance spectroscopy of serum lipoproteins in rabbits with implanted VX-2 carcinoma.

Serum from two groups of rabbits, all offspring from the same parents, was subjected to NMR spectroscopy in order to monitor the progress of malignant disease. One group had VX-2 carcinoma implanted in the kidney while the control group were sham-operated with injection of physiological saline. Later, the control group was subjected to dietary restrictions to produce a weight loss equivalent to that of the rabbits with tumor. Progressive cancerous growth with cachexia produced characteristic changes in the lipoprotein spectra distinctly different from those induced by weight loss induced by food intake restrictions. A shoulder on the high-field side of the methylene resonance observed in the control spectra disappeared during the progress of cancerous growth. These spectral changes, however, are not adequately described by line width measurements at half-height as suggested for the original Fossel test.

Animals↗
PubMed1989

[ACE inhibitors].

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Angiotensin-Converting Enzyme Inhibitors↗
PubMed1989

Effects of toluene on protein synthesis and the interaction with ethanol in hepatocytes isolated from fed and fasted rats.

The effects of three different concentrations (about 10, 100 and 1000 microM) of toluene on protein synthesis were studied in hepatocytes isolated from fed and fasted rats after 60 and 120 min. of incubation. The interaction between ethanol (60 mM) and the low and high toluene concentrations were also tested. To measure protein synthesis, 14C-valine was used as the precursor amino acid. Total valine concentration was 2 mM to ensure near-constant specific radioactivity of precursor. Toluene concentrations were measured by head-space gas chromatography. Protein synthesis was unchanged in the presence of low toluene concentrations. Intermediate toluene concentration decreased protein synthesis by about 20% and high toluene concentration decreased protein synthesis by about 60%. Protein synthesis was similar in cells from fed and fasted rats. Ethanol alone inhibited protein synthesis by 20-30%, more in fasted than in fed rats. Toluene and ethanol in combination inhibited protein synthesis additively. The high toluene concentration with or without ethanol appeared to inhibit synthesis/secretion of export proteins in hepatocytes from fasted rats. In conclusion, our study indicates that toluene in relatively high concentrations inhibits general protein synthesis in isolated rat hepatocytes. Toluene and ethanol seems to inhibit protein synthesis additively.

Animals↗
PubMed1989

Continuing reject-repeat film analysis program.

A continuing image quality assurance and control program has been employed in the Department for over 9 years. One of the tools used in assessing quality has been reject-repeat analyses performed 9 times. The reject rate dropped from 15% in 1980-1981 to 8.4% in 1982. After moving to a new department with new film processing systems and, in part, new diagnostic equipment, the rejection rate increased to 13.2%. New and renewed procedures such as increased control and adjustment of technical equipment (in particular the automatic daylight film processing systems), information and education, decreased the rejection rates to 9.2 and 6.6% on 2 analysis occasions in 1987, and to 6.4% in 1988. Image quality assurance and control have to be continuous activities if they are to yield favourable and economically justifiable results.

Cost-Benefit Analysis↗
PubMed1988

The changing scene of radiology: value of urography as initial examination in infectious and hypertensive disease, hematuria and malignant disease.

Four to 20% positive findings were found in a review of 1913 excretory urographics. Possibly relevant findings were 20% in patients referred for infectious disease, 10% in hypertensive disease, 6% in hematuria and 4% in neoplasms. Urography influenced treatment mainly in the 2 groups with few positive findings. The costs for positive findings may be acceptable in patients with hematuria or suspicion of neoplasms, but are too high in the other groups. Until ultrasonography can replace intravenous urography as the first screening method in upper urinary tract disease, the patient selection for urography in infectious and hypertensive disease should be improved.

Adult↗