Biomedical subjects
Publications and source records attributed to G Gacon.
Haemoglobin Belfast was initially observed in an Irish patient. The second case, found in a French patient suffering from a metastatic carcinoma, is here described. Both observations are compared from clinical, haematological and biochemical points of view. Functional and spectrophotometrical studies confirmed the slight abnormalities already described.
Hemoglobin Casper (beta106Leu replaced by Pro) can be separated from hemoglobin (Hb) A by isoelectric focusing on polyacrylamide gel. This abnormal hemoglobin was estimated to be 30% of teh total by both isoelectric focusing and heat lability kinetics. Its oxygen equilibrium curves indicate a high oxygen affinity, low degree of subunit interaction, and a decreased Bohr effect. Mixtures of Hb Casper and Hb A appear to bind oxygen as if no hybrid molecules exist.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The authors have operated on seventy instances of para-articular ectopic bone formation in fifty patients. Seventeen were paraplegic or tetraplegic, thirty were the result of trauma, two resulted from meningitis and one was a sequel of burns. The ectopic bone was located at the hip (thirty-three cases), the elbow (twenty-three cases), the knee (twelve cases) and the shoulder (two cases). The clinical, radiological and pathological features are reviewed. Several hypotheses on the mechanism of ectopic bone formation are put forward. The surgical procedures have included arthrolysis, arthrodesis, wide resection of the epiphysis, and total prostheses. There were ten recurrences. The authors conclude that the most extensive lesions occur in paraplegia and when the bone formation is situated at the hip.