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Biomedical subjects

G G WRIGHT

Publications and source records attributed to G G WRIGHT.

25 records · Page 2Linked to original sources
PubMed1951

Studies on immunity in anthrax. I. Variation in the serum T-agglutinin during anthrax infection in the rabbit.

An abrupt decrease in the titer of serum T-agglutinin frequently occurs during the acute phase of anthrax infection in the rabbit. In partially immunized animals which survive the infection the titer returns to normal during convalescence, but has not been observed to rise significantly above the normal level. The presence of a substance capable of inhibiting T-agglutination may be demonstrated in the sera of many of those animals in which a marked decrease in T-agglutinin has occurred. The polysaccharide and polypeptide antigens of B. anthracis do not possess this activity. Sera containing the T-inhibitory substance usually produce a slow hemolysis of T-erythrocytes and also of normal human type O erythrocytes; hemolysis of erythrocytes of other species is irregular. This reactivity of the sera withstands inactivation at 56 degrees C. but is inhibited by citrate. T-inhibitory and hemolytic activities can frequently be increased by incubation of the acute-phase serum at 37 degrees C. The ability of normal serum to neutralize the T-inhibitory and hemolytic activities of acute-phase serum is not significantly increased after recovery from the infection. The meaning of the results is discussed.

Animals↗
PubMed1951

Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis.

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.

Animals↗
PubMed1950

Observations on the agglutination of polysaccharide-treated erythrocytes by tularemia antisera.

Erythrocytes treated with polysaccharide from Past. tularensis are specifically agglutinated by the sera of persons recovered from tularemia or vaccinated against it, and by the sera of animals immunized with living cultures. The serum hemagglutination titer is correlated with the amount of antibody as measured by the quantitative precipitin method with polysaccharide, but not with the bacterial agglutination titer. The meaning of the results is discussed.

Agglutination↗