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Biomedical subjects

G G Tsymbalar'

Publications and source records attributed to G G Tsymbalar'.

12 recordsLinked to original sources

[Current characteristics of advanced and rapidly progressive forms of pulmonary tuberculosis].

Tuberculosis morbidity and mortality in the Moldova Republic has deteriorated since 1991. The percentage of advanced and rapidly progressive forms of the disease rose 2-3-fold. Most of the patients are 21-50-year-old unemployed men living in poor financial and social conditions. Advanced and rapidly progressive tuberculosis forms present clinically with multiple symptoms and destructions, high incidence of generalized dissemination and involvement of the brain. Treatment effectiveness depends on feasibility of combined therapy incorporating 4-5 antituberculous drugs. After the treatment, 84.1% of the patients stopped bacterial discharge, closure of the caverns was achieved in 55.3% of the patients.

Acute Disease↗

[Organization of medical services for patients with nonspecific diseases of the respiratory organs in the regions with predominantly rural population].

Pneumologic bed demand for adult population was established (0.6 per 1000 residents) and data are given concerning the organization of specialized pneumologic departments at the republican, urban and rural level. The expediency of establishing payment rate for pneumotologists at CRH polyclinics in regions with numerous adult population (40,000 residents and more) was shown. Data are presented on the coverage of outpatient follow-up of patients with nonspecific respiratory diseases, on mortality from all nonspecific pulmonary diseases and pneumonia for 1986-1989. The mortality rates were found to be reduced during this period by 34.9% and 47.4%, respectively.

Adolescent↗

[A method of differentiating transudate and exudate].

A diagnostic value of pleural fluid alkaline phosphatase (AP) for transudate and exudate differentiation is shown. AP below and above 0.5 mumol/(ml.h) are characteristic of transudate and exudate, respectively.

Alkaline Phosphatase↗

[Biochemical study of the pleural fluid in exudative pleurisy].

The authors relate the data on the importance of a biochemical analysis of the pleural fluid for the differential diagnosis of pleurisy and identification of the early signs of pleural fluid suppuration. For the purposes of the differential diagnosis between transudates and exudates measurements are made of the protein content and LDH activity in the pleural fluid. The exudate protein/serum protein and exudate LDH/serum LDH ratios are computed in necessary cases. The high prothrombin index (over 100%) and the level of lysozyme (over 25 (micrograms/ml) in the pleural fluid provide evidence in favour of the tuberculous etiology of pleurisy. The low level of glucose (under 2 mmol/l), high activity of LDH (over 6.2 mmol/l) and the negative ethanol test may point to the initial signs of exudate suppuration.

Algorithms↗

[Pathogenetic agents in the complex treatment of patients with tuberculous pleurisy].

Data on therapy of 257 patients with tuberculous pleurisy and the clinicoroentgenological outcomes at the hospitalization stage were studied. 180 of them were treated pathogenetically in addition to the use of etiotropic drugs. The pathogenetic treatment included the use of prednisolone, tuberculin, pyrogenal, phonophoresis or electrophoresis with heparin. For estimating the therapy efficiency x-ray criteria of the size of residual pleural lesions after exudate resolution were developed. It was shown that inclusion of the pathogenetic treatment into combined therapy of the patients with tuberculous pleurisy markedly increased its efficiency and led to more favourable clinicoroentgenological outcomes. The results were especially favourable with tuberculin and successive application of the pathogenetic treatment corresponding to the process phase.

Adolescent↗

[Alteration in activities of NAD-glycohydrolase, acid and alkaline phosphatases in blood cells tuberculosis].

Activities of NAD-glyconydrolase from erythrocytes, alkaline and acid phosphatases from neutrophiles and acid phosphatase from lymphocytes were studied in patients with pulmonary tuberculosis as well as in experimental animals. Distinct alterations in the activity of the enzymes studied were observed in blood cells of guinea pigs inoculated with tuberculosis. In patients with active pulmonary tuberculosis activities of acid and alkaline phosphatases were altered in leukocytes and the activity of NAD-glycohydrolase--in erythrocytes. Inactive forms of tuberculosis were accompanied by a slight alterations in the alkaline phosphatase activity, activities of acid phosphatase and NAD-glycohydrolase were unaltered.

Acid Phosphatase↗