Vancomycin-resistant enterococci in a district general hospital.
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Biomedical subjects
Publications and source records attributed to G G Rao.
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Enteropathogenic Escherichia coli (EPEC) is a well-recognized cause of infantile diarrhoea in the developing countries. In the developed countries, however, the incidence of EPEC associated outbreaks has dramatically declined. The last major outbreak in the UK was reported in 1980. This paper reviews the recent advances in the field of pathogenesis of diarrhoea caused by EPEC and questions the need to screen routinely for EPEC by conventional serological methods used in clinical microbiology laboratories in the UK.
The distribution and clinical management of thirty-two hospitalized patients with salmonella and campylobacter infections were reviewed and the impact of these infections on hospital resources was assessed. Eighteen patients with salmonella infection had an age and sex distribution comparable with the community cases. In contrast, 10 out of 14 (71.4%) patients with campylobacter infection were under 20 years of age though the peak incidence of the infection in the community occurred in the 21-65 years age group (67%). There was no male predominance. The median duration of stay in hospital was 6 days for patients with salmonella infection and 3 days for those with campylobacter infection. Physicians were inconsistent in the treatment of campylobacter infection. Overall the financial impact of managing patients with salmonella and campylobacter infection was considerable (1384 pounds and 779 pounds respectively per patient). A limitation on unnecessarily prolonged hospital stays and the establishment of clear guidelines for the clinical management of these infections are necessary.
Ciprofloxacin is an uncommon cause of pseudomembranous colitis. A case is described in which diarrhoea was associated with the presence of clostridial toxin in an HIV-infected patient and the possible implications are discussed.
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The effect of routine cleaning in removing Campylobacter pylori from the biopsy forceps of endoscopes has been examined in a series of 50 patients. Campylobacter pylori was isolated from the biopsies of 15 of the patients, while one of the 50 biopsy forceps washings yielded the organism after routine cleaning. This study suggests that there is a small chance of transmitting C. pylori by endoscopic equipment if cleaning is the only method of decontamination adopted.
Exfoliation rates of urothelial cells following bladder irrigation were studied in patients with long-term indwelling catheters and chronic urinary tract infections (UTI). The irrigations were associated with an increased shedding of urothelial cells. Ultrastructural studies of these cells demonstrated increased disruption when compared with those obtained from normal subjects without catheters or chronic infection. The findings suggest that bladder irrigation further damages the already disrupted urothelium, which may in turn increase the predisposition of the bladder to the recurrent infections, commonly associated with patients who have indwelling urinary catheters. Bladder irrigation methods and the indications for their use require reassessment.
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